Skin treatment method

• US 4,908,355 A
• Filed: 01/09/1989
• Issued: 03/13/1990
• Est. Priority Date: 01/09/1989
• Status: Expired due to Term

• Current Assignee: Dow Corning Corporation (Dow, Inc.)
• Original Assignee: Dow Corning Corporation (Dow, Inc.)
• Inventors: White, William C., Gettings, Richard L.
• Primary Examiner(s): Daus, Donald G.
• Application Number:
  US07/294,724
• Time in Patent Office: 428 Days
• Field of Search: 514/63
• US Class Current: 514/63
• CPC Class Codes: A61K 31/695 Silicon compounds
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders

Abstract

A method of treating skin disorders such as acne vulgaris by applying topically to the epidermis a composition of an emulsion in which there is present a silane and a volatile low viscosity low molecular weight water immiscible liquid of a silicone fluid, causing the silane to penetrate follicular orifices, using the volatile silicone fluid for the purpose of driving the silane into sebaceous glands, and destroying members of the staphylococcal group of bacteria therein. An abrasive, astringent, and fragrance may also be included. This method also allows for the treatment of dermatosis, such as ring worm and athlete'"'"'s foot.

Claims

1. A method of treating acne vulgaris comprising applying topically to the epidermis a mixture of an antibacterially effective amount of a silane and a water immiscible liquid, the silane being an organosilicon quaternary ammonium compound and an organosilane having the formula selected from the group consisting of ##STR8## wherein, in each formula, Y is R or RO where each R is an alkyl radical of 1 to 4 carbon atoms or hydrogen;

a has a value of 0, 1 or 2;

R'"'"' is a methyl or ethyl radical;

R" is an alkylene group of 1 to 4 carbon atoms;

R'"'"'", R"" and R^v are each independently selected from a group consisting of alkyl radicals of 1 to 18 carbon atoms, --CH₂ C₆ H₅, --CH₂ CH₂ OH, --CH₂ OH, and --(CH₂)_x NHC(O)R^vi, wherein x has a value of from 2 to 10 and R^vi is a perfluoroalkyl radical having from 1 to 12 carbon atoms; and

X is chloride, bromide, fluoride, iodide, acetate or tosylate, the water immiscible liquid being a polysiloxane having the formula (R'"'"'R"SiO)_y wherein R'"'"' is an alkyl radical of 1 to 3 carbon atoms;

R" is an alkyl radical of 1 or 2 carbon atoms; and

y has a value of 3 to 5.

2. The method of claim 1 wherein the composition includes an abrasive selected from the group consisting of pumice, talc, mica, iron oxide, titanium oxide, titanium dioxide, zinc oxide, kaolin, magnesium oxide, zinc stearate, magnesium stearate, starch, chalk, magnesium carbonate, and boric acid.

3. The method of claim 2 wherein the composition includes an astrigent selected from the group consisting of alum, silver nitrate, aluminum sulphate, aluminum chlorohydrate, zinc chloride, zinc chlorohydrate, aluminum-zirconium chlorohydrate, aluminum chlorohydroxide, zirconium hydroxychloride, aluminum hydroxychloride-zirconyl hydroxy oxychloride, and aluminum-zirconium tetrachlorohydrex-glycinate.

4. The method of claim 3 wherein the composition includes a fragrance.

5. The method of claim 4 wherein the polysiloxane is polydimethylcyclosiloxane.

6. A method as claimed in claim 1 wherein the organosilicon compound has the formula ##STR9## wherein each R is an alkyl radical of 1 to 4 carbon atoms or hydrogen;

a has a value of 0,1 or 2;

R'"'"' is a methyl or ethyl radical;

R" is an alkylene group of 1 to 4 carbon atoms;

R'"'"'", R"" and R^v are each independently selected from a group consisting of alkyl radicals of 1 to 18 carbon atoms, --CH₂ C₆ H₅, --CH₂ CH₂ OH, --CH₂ OH, and --(CH₂)_x NHC(O)R^vi, wherein x has a value of from 2 to 10 and R^vi is a perfluoroalkyl radical having from 1 to 12 carbon atoms;

X is chloride, bromide, fluoride, iodide, acetate or tosylate.

7. A method as claimed in claim 1 wherein the organosilicon compound has the formula ##STR10## wherein R is an alkyl radical of 1 to 4 carbon atoms or hydrogen;

a has a value of 0, 1 or 2;

R'"'"' is a methyl or ethyl radical;

R" is an alkylene of 1 to 4 carbon atoms;

X is chloride, bromide, fluoride, iodide, acetate or tosylate.