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Skin treatment method

  • US 4,908,355 A
  • Filed: 01/09/1989
  • Issued: 03/13/1990
  • Est. Priority Date: 01/09/1989
  • Status: Expired due to Term
First Claim
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1. A method of treating acne vulgaris comprising applying topically to the epidermis a mixture of an antibacterially effective amount of a silane and a water immiscible liquid, the silane being an organosilicon quaternary ammonium compound and an organosilane having the formula selected from the group consisting of ##STR8## wherein, in each formula, Y is R or RO where each R is an alkyl radical of 1 to 4 carbon atoms or hydrogen;

  • a has a value of 0, 1 or 2;

    R'"'"' is a methyl or ethyl radical;

    R" is an alkylene group of 1 to 4 carbon atoms;

    R'"'"'", R"" and Rv are each independently selected from a group consisting of alkyl radicals of 1 to 18 carbon atoms, --CH2 C6 H5, --CH2 CH2 OH, --CH2 OH, and --(CH2)x NHC(O)Rvi, wherein x has a value of from 2 to 10 and Rvi is a perfluoroalkyl radical having from 1 to 12 carbon atoms; and

    X is chloride, bromide, fluoride, iodide, acetate or tosylate, the water immiscible liquid being a polysiloxane having the formula (R'"'"'R"SiO)y wherein R'"'"' is an alkyl radical of 1 to 3 carbon atoms;

    R" is an alkyl radical of 1 or 2 carbon atoms; and

    y has a value of 3 to 5.

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