Methods for preventing thrombosis; and surgical implant having reduced platelet deposition characteristics
First Claim
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1. A method for reducing the incidence of thrombosis in a patient following a surgical implant procedure on the patient comprising the steps of:
- applying 7B-acetoxy-8,13-epoxy-1a-6B,9a-trihydroxylabd-14-en-11-one (Forskolin) or a derivative thereof to a surgical implant, andthereafter, implanting the surgical implant with the Forskolin or a derivative thereof thereon into the patient.
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Abstract
In order to improve the surface properties of small caliber vascular grafts or other surgical implants, Forskolin (or a derivative thereof) which is a power cAMP stimulating agent, is applied to the thrombogenic surfaces of the graft/implant. Forskolin as thus used is a potent antiplatelet agent significantly lowering platelet deposition on the implant.
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Citations
34 Claims
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1. A method for reducing the incidence of thrombosis in a patient following a surgical implant procedure on the patient comprising the steps of:
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applying 7B-acetoxy-8,13-epoxy-1a-6B,9a-trihydroxylabd-14-en-11-one (Forskolin) or a derivative thereof to a surgical implant, and thereafter, implanting the surgical implant with the Forskolin or a derivative thereof thereon into the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24)
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23. A method for preventing undue platelet aggregation on a synthetic vascular graft used in cardiovascular surgery on a patient comprising the steps of:
before implanting the synthetic vascular graft in the patient, applying locally to the graft 7B-acetoxy-8, 13-epoxy-1a-6, 9a-trihydroxylabd-14-en-11-one (Forskolin) or a derivative thereof.
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25. An implant device suitable for surgical implantation in a patient and showing low resulting platelet deposition thereon comprising:
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a surgical implant having an implant thrombogenic surface, and a coating of 7B-acetoxy-8,13-epoxy-1a-6B,9a-trihydroxylabd-14-en-11-one (Forskolin) or a derivative thereof on said implant thrombogenic surface. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification