Roller bottle
First Claim
1. A roller bottle for cell growth culturing, characterized by(a) a substantially cylindrical housing open at both ends, and defining a hollow cell growth chamber in said roller bottle;
- (b) a bottom end cap for closing one end of said housing;
(c) a top cap for closing the end of said housing opposite said bottom cap;
(d) an opening positioned centrally of said top cap for gaining access to said cell growth chamber;
(e) a closure cap for closing said opening in said top cap;
(f) first cooperating joining means on said housing and said bottom end cap for joining said bottom end cap to said housing;
(g) second cooperating joining means on said housing and said top cap for joining said top cap to said housing; and
(h) a liner comprised of a single layer sleeve for lining the walls of said hollow growth chamber;
(i) said liner comprised of a material presenting a textured uneven surface to increase the effective surface area for cell growth in said chamber.
1 Assignment
0 Petitions
Accused Products
Abstract
A roller bottle is provided with provision for increased internal surface area for cell growth by the use of a foamed, textured or woven liner or sleeve inserted into the bottle prior to use. The sleeve may be used in a single use roller bottle or a multiple use roller bottle. With the latter, the sleeve is discarded, the bottle sterilized, and a new sleeve or liner is inserted. The interstices of the foamed, textured or woven surface has the effect of increasing the actual surface area available for culturing cells in each single roller bottle, thus making the roller bottle of the invention cost effective.
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Citations
10 Claims
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1. A roller bottle for cell growth culturing, characterized by
(a) a substantially cylindrical housing open at both ends, and defining a hollow cell growth chamber in said roller bottle; -
(b) a bottom end cap for closing one end of said housing; (c) a top cap for closing the end of said housing opposite said bottom cap; (d) an opening positioned centrally of said top cap for gaining access to said cell growth chamber; (e) a closure cap for closing said opening in said top cap; (f) first cooperating joining means on said housing and said bottom end cap for joining said bottom end cap to said housing; (g) second cooperating joining means on said housing and said top cap for joining said top cap to said housing; and (h) a liner comprised of a single layer sleeve for lining the walls of said hollow growth chamber; (i) said liner comprised of a material presenting a textured uneven surface to increase the effective surface area for cell growth in said chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A liner for use in a roller bottle, characterized by
(a) a cylindrical liner body comprised of a single layer for lining the internal surface of a roller bottle; -
(b) said body defining a hollow liner chamber therein; (c) the walls of said hollow liner chamber being textured and uneven for presenting an increase in effective cell growth surface area in said hollow liner chamber; and (d) said liner being inserted into a roller bottle prior to final closure thereof. - View Dependent Claims (9, 10)
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Specification