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Method for treating hypoxia

  • US 4,914,094 A
  • Filed: 03/21/1989
  • Issued: 04/03/1990
  • Est. Priority Date: 12/09/1985
  • Status: Expired due to Fees
First Claim
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1. A method for treating hypoxia comprising, administering to a host in need of said treatment a compound or salt thereof represented by formula (1), ##STR13## wherein R1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a phenyl-lower alkyl group;

  • Z is a group of the formula ##STR14## in which R2 is a hydrogen atom or a lower alkyl group; and

    the bond indicated as is a single or double bond, a group of the formula --(CH2)3 --, a group of the formula --O--CH2 -- or a group of the formula --S--CH2 --;

    R3 is a pyridyl group, or a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, a lower alkyl group, a lower alkoxy group and a hydroxy group; and

    a group of the formula ##STR15## is a group of the formula ##STR16## and A is a lower alkylene group;

    provided that when a group of the formula ##STR17## is a group of the formula ##STR18## then Z is a group of the formula ##STR19## and at the same time R3 should be neither a pyridyl group nor a phenyl group having at least one hydroxy group as the substituent;

    or when R3 is a pyridyl group, then Z is a group of the formula ##STR20##

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