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Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange

  • US 4,915,685 A
  • Filed: 06/19/1987
  • Issued: 04/10/1990
  • Est. Priority Date: 03/19/1986
  • Status: Expired due to Term
First Claim
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1. A method for iontophoretically administering a medicament through the skin of a patient while simultaneously removing competing ions from the medicament medium, the method comprising the steps of:

  • (a) obtaining an ion exchange matrix and a drug comprising medicament ions which are insoluble in an iontophoresis medium and complementary ions;

    (b) obtaining a first electrode and a second electrode;

    (c) obtaining an iontophoresis medium;

    (d) placing the ion exchange matrix and the drug in communication with iontophoresis medium such that the medicament ions are precipitated onto the ion exchange matrix;

    (e) placing the first electrode in communication with the iontophoresis medium;

    (f) placing the iontophoresis medium in communication with the patient such that the medium is disposed between the first electrode and the skin of the patient;

    (g) placing the second electrode in communication with the skin of the patient at a point distal from the first electrode; and

    (h) creating an electrical voltage difference between the first and second electrodes, said voltage difference causing the electrolysis reaction of water, the products of the electrolysis of water acting to solubilize the medicament such that the medicament ions are transported through the skin of the patient, while an approximately constant pH is maintained within the iontophoresis medium.

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