Dosage form for delivering a drug at two different rates

• US 4,915,954 A
• Filed: 02/21/1989
• Issued: 04/10/1990
• Est. Priority Date: 09/03/1987
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Magruder, Paul R., Edgren, David E., Ayer, Atul D., Jordan, Maureen L.
• Primary Examiner(s): Swisher, Nancy A. B.
• Application Number:
  US07/313,006
• Time in Patent Office: 413 Days
• Field of Search: 424/467-473
• US Class Current: 424/473
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.

Claims

1. A dosage form for delivering a drug to an animal, wherein the dosage form comprises:

(a) a wall comprising at least in part a composition permeable to fluid;

(b) a compartment defined by the wall;

(c) a first composition in the compartment comprising (1) a drug selected from the group consisting of cimetidine, ranitidine, nizatidine, roxatidine and famotidine, and (2) a hydroxypropylcellulose comprising about 7% to 16% hydroxypropyl group;

(d) a second composition in the compartment comprising (3) a drug selected from the group consisting of cimetidine, ranitidine, nizatidine, roxatidine and famotidine, and (4) a member selected from the group consisting of a hydroxypropylmethylcellulose and a hydrogel; and

,

(e) exit means for delivering the first composition in a short period of time.

2. A dosage form for delivering a drug orally to an animal, wherein the dosage form comprises:

(a) a wall comprising at least in part a composition permeable to fluid;

(b) a compartment formed by the wall;

(c) a first composition in the compartment comprising (1) a drug selected from the group consisting of captopril, ramipril, enalapril, enalaprilat and lisinopril, and (2) a hydroxypropylcellulose comprising about 7% to 16% hydroxypropyl group;

(d) a second composition in the compartment comprising (3) a drug selected from the group consisting of captopril, ramipril, enalapril, enalaprilat and lisinopril, and (4) a member selected from the group consisting of hydroxypropylmethylcellulose and hydrogel; and

,

(e) exit means for delivering the first composition in a short period of time to the animal.

3. A dosage form for delivering a drug orally to an animal, wherein the dosage form comprises:

(a) a wall comprising at least in part a composition permeable to fluid;

(b) a compartment formed by the wall;

(c) a first composition in the compartment comprising (1) a drug selected from the group consisting of colestipol, pravastatin, lovastatin, simvastatin and fluindostatin and (2) a hydroxypropylcellulose comprising about 7% to 16% hydroxypropyl group;

(d) a second composition in the compartment comprising (3) a drug selected from the group consisting of colestipol, pravastatin, lovastatin, simvastatin, and fluindostatin, and (4) a member selected from the group consisting of hydroxyproylmetylcellulose and a hydrogel; and

,

(e) exit means for delivering the first composition in a short period of time to the animal.