Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides

• US 4,916,193 A
• Filed: 08/01/1988
• Issued: 04/10/1990
• Est. Priority Date: 12/17/1987
• Status: Expired due to Term

• Current Assignee: United States Surgical Corporation (Medtronic Plc)
• Original Assignee: Alliedsignal Inc.
• Inventors: Mares, Frank, Boyle, William J. Jr., Chiu, Tin-Ho, Patel, Kundanbhai M., Tang, Reginald T.
• Primary Examiner(s): NOT, DEFINED
• Application Number:
  US07/226,706
• Time in Patent Office: 617 Days
• Field of Search: 528/354, 528/370, 523/111, 523/105, 523/113, 128/334, 128/335.5, 525/461, 525/411, 525/413, 525/415, 525/186, 525/187
• US Class Current: 525/413
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61L 17/10 containing macromolecular materials
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: C08L 69/00 Compositions of polycarbonates; Compositions of derivatives of polycarbonates

Abstract

This invention relates to novel copolymers containing carbonate repeat units and ester repeat units.

Claims

1. A medical device formed totally or in part of one or more block copolymers having at least one type of recurring monomeric unit of the General Structure I:

##STR7## and having at least one type of recurring monomeric units of the Structure II;

##STR8## wherein;

n is from 1 to about 8; and

R₁ and R₂ are the same or different and are hydrogen, alkyl or phenyl with the proviso that at least one of R₁ and R₂ is other than hydrogen.

2. A medical device according to claim 1 wherein n is 1 to about 3.

3. A medical device according to claim 2 wherein n is 1.

4. A medical device according to claim 1 wherein R₁ and R₂ are the same or different and are hydrogen or alkyl.

5. A medical device according to claim 4 wherein R₁ and R₂ are the same or different and are hydrogen or alkyl having from 1 to about 4 carbon atoms.

6. A medical device according to claim 5 wherein the recurring monomeric units of the Structure II are derived from a lactide.

7. A medical device according to claim 6 wherein the recurring monomeric units of the Structure II are derived from d-lactide, l-lactide or d,l-lactide.

8. A medical device according to claim 1 wherein the amount of the recurring monomeric units of the Structure I in said copolymer is at least about 75 wt. % based on the total weight of recurring monomer units.

9. A medical device according to claim 8 wherein said amount is at least about 85 wt. %.

10. A medical device according to claim 9 wherein said amount is from about 85 wt. % to about 99 wt. %.

11. A medical device according to claim 10 wherein said amount is from about 90 wt. % to about 99 wt. %.

12. A medical device according to claim 1 wherein said device further comprises a biodurable portion.

13. A medical device according to claim 1 which further comprises one or more other bioresorbable polymers.

14. A medical device according to claim 1 wherein said copolymer is a random copolymer.

15. A medical device according to claim 1 wherein said block copolymer has an AB or an ABA structure wherein A is a block of recurring monomeric units of the Structure I or of the Structure II, and B is a block of a recurring monomeric units of the Structure I, the Structure II or a random block or recurring units of the Structure I and II, with the proviso that when A is composed of units of the Structure I, B is composed of units of the Structure II or is a random block, and that when A is composed of units of the Structure II, B is composed of units of the Structure I or is a random block.

16. A medical device according to claim 15 wherein said block copolymer is a block copolymer of the structure ABA.

17. A block copolymer having at least one type of recurring monomeric units of the Structure I:

##STR9## and having at least one type of recurring monomeric unit of the Structure II;

##STR10## wherein;

n is from 1 to about 8; and

R₁ and R₂ are the same or different and are hydrogen, alkyl or phenyl with the proviso that at least one of R₁ and R₂ is other than hydrogen.

18. A block copolymer according to claim 17 wherein n is 1 to about 3.

19. A block copolymer according to claim 18 wherein n is 1.

20. A block copolymer according to claim 17 wherein R₁ and R₂ are the same or different and are hydrogen or alkyl

21. A block copolymer according to claim 20 wherein R₁ and R₂ are the same or different and are hydrogen or alkyl having from 1 to about 4 carbon atoms.

22. A block copolymer according to claim 21 wherein the recurring monomeric units of the Structure II are derived from a lactide.

23. A block copolymer according to claim 22 wherein the recurring monomeric units of the Structure II are derived from d-lactide, l-lactide or d,l-lactide.

24. A block copolymer according to claim 17 wherein the amount of the recurring monomeric units of the Structure I in said copolymer is at least about 75 wt. % based on the total weight of recurring monomer units.

25. A block copolymer according to claim 24 wherein said amount is at least about 85 wt. %.

26. A block copolymer according to claim 25 wherein said amount is from about 85 wt. % to about 99 wt. %.

27. A block copolymer according to claim 26 wherein said amount is from about 90 wt. % to about 99 wt. %.

28. A block copolymer according to claim 17 wherein said block copolymer has an AB or an ABA structure wherein A is a block of recurring monomeric units of the Structure I or of the Structure II, and B is a block of a recurring monomeric units of the Structure I, the Structure II or a random block or recurring units of the Structure I and II, with the proviso that when A is composed of units of the Structure I, B is composed of units of the Structure II or is a random block, and that when A is composed of units of the Structure II, B is composed of units of Structure I or is a random block.

29. A block copolymer according to claim 28 wherein said block copolymer is a block copolymer of the structure ABA.