Infrared laser catheter system

• US 4,917,084 A
• Filed: 03/10/1988
• Issued: 04/17/1990
• Est. Priority Date: 07/31/1985
• Status: Expired due to Term

• Current Assignee: Cardiofocus Incorporated
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Sinofsky, Edward L.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Shay, David
• Application Number:
  US07/166,315
• Time in Patent Office: 768 Days
• Field of Search: 128/303.1, 128/395, 128/387, 128/398
• US Class Current: 606/7
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 2018/2065 Multiwave; Wavelength mixing, e.g. using four or more wavelengths pilot laser A61B2018/2025
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: G02B 6/4296 coupling with sources of high radiant energy, e.g. high power lasers, high temperature light sources

Abstract

Laser energy produced by a laser operating in the mid-infrared region (approximately 2 micrometers) is delivered by an optical fiber in a catheter to a surgical site for biological tissue removal and repair. Disclosed laser sources which have an output wavelength in this region include: Holmium-doped Yttrium Aluminum Garnet (Ho:YAG), Holmium-doped Yttrium Lithium Fluoride (Ho:YLF), Holmium-doped Yttrium-Scandium-Gadolinium=Garnet (HO:YSGG), Erbium-doped YAG, Erbium-doped YLF and Thulium-doped YAG. Laser output energy is applied to a silica-based optical fiber which has been specially purified to reduce the hydroxyl-ion concentration to a low level. The catheter may be comprised of a single optical fiber or a plurality of optical fibers arranged to give overlapping output patterns for large area coverage. In a preferred application for the removal of atheroscleotic plaque, a Holmium-doped laser operating in the wavelength range of from about 1.9 to about 2.1 micrometers is preferred. For removal of such plaque by a Holmium-doped laser, it has been found that the threshold energy density should be greater than about 0.6 joules/mm² per pulse, and that the pulse width should be substantially less than about 83 milliseconds, and that the repetition rate should be in the range of from about 1 to about 10 Hertz.

Claims

1. A system for the surgical removal of atherosclerotic plaque comprising:

a laser energy source operating in a pulsed mode with an output wavelength in the range of from about 1.4 to about 2.2 micrometers, said laser energy source operating at an energy density of at least about 0.6 joules per square millimeter per pulse;

an optical fiber;

means for coupling an output of said laser source to a proximal end of said optical fiber; and

means attached to a distal end of said optical fiber for directing laser energy propagating down said optical fiber to a surgical site within the body.

2. A system as recited in claim 1 wherein said laser energy source comprises a Holmium-doped laser with an output wavelength in the range of from about 1.9 to about 2.1 micrometers.

3. A system as recited in claim 1 wherein said laser energy source is a Holmium doped Yttrium-Scandium-Gadolinium Garnet laser having an output wavelength of 2.088 micrometers.

4. A system as recited in claim 1 wherein the pulse width of each pulse is substantially less than about 83 milliseconds.

5. A system as recited in claim 4 wherein the pulse width is of the order of about 8 milliseconds.

6. A system as recited in claim 1 wherein said optical fiber comprises a silica fiber purified to reduce the hydroxyl ion content as low as possible.

7. A system as recited in claim 1 wherein said laser source comprises a Holmium-doped Yttrium-Aluminium-Garnet laser.

8. A system as recited in claim 1 wherein said laser source comprises a Holmium doped Yttrium-Lithium-Fluoride laser.

9. A system as recited in claim 1 wherein said laser source comprises an Erbium-doped Yttrium-Lithium-Fluoride laser.

10. A system as recited in claim 1 wherein said laser source comprises a Thulium doped Yttrium-Aluminium-Garnet laser.

11. A system as recited in claim 1 further comprising an aiming laser source generating a visible light output and means for directing said visible light output through said laser source and said optical fiber to align said laser and said fiber to visually illuminate said surgical site.

12. A system as recited in claim 1 wherein said optical fiber further comprises:

a plurality of optical fibers having proximal and distal ends;

a plurality of partially reflective mirrors arranged in series along an axis of an output beam emitted by said laser source for directing a portion of said output beam of said laser source to said proximal ends of said optica fibers; and

a plurality of focusing lenses positioned between said mirrors and said proximal ends of said fibers for focusing portions of said laser output to said proximal ends of said fibers;

said directing means holding said fibers in a fixed position relative to one another so that optical beams emanating from said distal ends of said fibers overlap to cover an area at least equal to the diameter of said directing means.

13. A system for the surgical removal of atherosclerotic plaque comprising:

a Holmium-doped laser energy source operating in a pulsed mode with an output wavelength in the range of from about 1.90 to about 2.1 micrometers, said laser energy source operating at an energy density of at least about 0.6 joules per square millimeter per pulse, said laser being operated with a pulse width substantially less than about 83 milliseconds and at a repetition rate in the range of from about 1 to about 10 Hertz;

an optical fiber;

means for directing an output of said laser source to a proximal end of said optical fiber; and

means attached to a distal end of said optical fiber for directing laser energy propagating down said optical fiber to a surgical site.

14. A system of the surgical removal of atherosclerotic plaque comprising:

an Erbium-doped YAG laser energy source operating in a pulsed mode with an output wavelength of about 1.55 micrometers, said laser energy source operating at an energy density of at least about 9.5×

10^-3 joules per square millimeter per pulse, said laser energy source being operated with a pulse width substantially less than about 83 milliseconds and at a repetition rate in the range of from about 1 to about 10 Hertz;

an optical fiber;

means for directing an output of said laser source to a proximal end of said optical fiber; and

means attached to a distal end of said optical fiber for directing laser energy propagating down said optical fiber to a surgical site.

15. A system for the surgical removal of atherosclerotic plaque comprising:

an Erbium-doped YLF laser energy source operating in a pulsed mode with an output wavelength of about 1.73 micrometers, said laser energy source operating at an energy density of at least about 5.7 joules per square millimeter per pulse, said laser energy source being operated with a pulse width substantially less than about 83 milliseconds and at a repetition rate in the range of from about 1 to about 10 Hertz;

an optical fiber;

means for directing an output of said laser source to a proximal end of said optical fiber; and

means attached to a distal end of said optical fiber for directing laser energy propagating down said optical fiber to a surgical site.

16. A system for the surgical removal of atherosclerotic plaque comprising:

a Thulium-doped YAG laser energy source operating in a pulsed mode with an output wavelength of about 1.88 micrometers, said laser energy source operating at an energy density of at least about 0.76 joules per square millimeter per pulse, said laser energy source being operated with a pulse width substantially less than about 83 milliseconds and at a repetition rate in the range from of about 1 to about 10 Hertz;

an optical fiber;

means for directing the output of said laser source to a proximal end of said optical fiber; and

means attached to a distal end of said optical fiber for directing laser energy propagating down said optical fiber to a surgical site.