Drug delivery article
First Claim
Patent Images
1. A drug delivery article comprising:
- (a) a drug; and
(b) a physically separate, non-combustion heat source for heating the drug, and including(i) a first chemical agent capable of interacting exothermically with a second chemical agent, and a third chemical agent capable of interacting exothermically with the first chemical agent, and(ii) a dispersing agent for the first agent.
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Accused Products
Abstract
A drug delivery article provides a dose of a volatilized drug by heating a drug carrying substrate, but not burning any material. A heat source which includes a metal oxide (e.g., calcium oxide), an anhydrous metal sulfate (e.g., magnesium sulfate), an inorganic salt and a sugar, generates heat upon contact of water therewith. The heat produced by the heat source heats the drug in a heat exchange relationship therewith. The drug volatilizes and is drawn into the mouth of the user of the article. Typical heat sources heat the drug to a temperature within 70° C. to 200° C. for 4 to 8 minutes.
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Citations
70 Claims
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1. A drug delivery article comprising:
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(a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and a third chemical agent capable of interacting exothermically with the first chemical agent, and (ii) a dispersing agent for the first agent. - View Dependent Claims (4, 7, 8, 9, 10, 11, 60)
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2. A drug delivery article comprising:
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(a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and (ii) a dispersing agent for the first agent, and (iii) a phase change material. - View Dependent Claims (3, 5, 6)
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12. A drug delivery article comprising:
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(a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) at least one chemical agent capable of interacting exothermically with water, and (ii) a dispersing agent for the chemical agent. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 59, 61, 67, 68)
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25. A drug delivery article comprising:
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(a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and (ii) a phase change material. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33)
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34. A drug delivery article comprising:
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(a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) at least one chemical agent capable of interacting exothermically with water, and (ii) a phase change material. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 62, 69)
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42. A drug delivery article comprising:
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(a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including; (i) a first chemical agent, (ii) a second chemical agent capable of interacting exothermically with the first chemical agent, (iii) a third chemical agent capable of interacting exothermically with the first chemical agent; the heat source being capable of heating at least a portion of the drug to at least about 70°
C. within 20 seconds of initiation and to a maximum temperature of less than about 200°
C. - View Dependent Claims (43, 44, 57, 63, 70)
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45. A drug delivery article comprising:
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(a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, the heat source including at least one chemical agent capable of interacting exothermically with water;
the heat source being capable of heating at least a portion of the drug to at least about 70°
C. within 20 seconds of initiation and to a maximum temperature of less than about 200°
C. - View Dependent Claims (46, 47, 58, 64)
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48. A drug delivery article comprising:
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(a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including; (i) first, second and third chemical agents capable of undergoing an exothermic chemical reaction with one another. (ii) a fourth agent capable of reacting with a reaction product of the exothermic chemical reaction to regenerate the second and third chemical agents for reaction with remaining first chemical agent. - View Dependent Claims (49, 50, 65)
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51. A drug delivery article comprising:
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(a) a drug; and (b) a physically separate, non-combustion heat source for heating the drug, and including (i) a first chemical agent capable of interacting exothermically with a second chemical agent, and (ii) a normally solid dispersing agent for the first agent. - View Dependent Claims (52, 53, 54, 55, 56, 66)
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Specification