Bone replacement material on the basis of carbonate and alkali containing calciumphosphate apatites
First Claim
1. An agent for filling bone defects, for building up bone, for forming bone-contact layers on the replacements of bones and roots of teeth and for making independent smaller bone replacement parts or implant articles, comprising a calcium phosphate apatite having carbonate and alkali portions, all ions being definedly integrated in the crystal lattice, of the following formula:
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space="preserve" listing-type="equation">Ca.sub.10-a-b-x Me.sup.II.sub.a Me.sup.I.sub.b (PO.sub.4).sub.6-x (CO.sub.3).sub.x (OH).sub.2-b-x (H.sub.2 O).sub.wwhereinMeI is a singly charged metal ion,MeII is a doubly charged metal ion,a represents the number of double charged metal ions with the exception of Ca and is a value from 0 to 1.0,b represents the number of singly charged metal ions and is a value from 0.05 to 1.2,x represents the number of carbonate ions and is a value from 0.02 to 1.2, the sum b+x being a maximum of 2.0, andw represents the number of water molecules integrated in the crystal lattice and is a value from 0 to b+xwherein at least a portion of the MeI ions are alkali ions and the CO3 ions are positioned at the PO4 positions within the apatite lattice.
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Abstract
This invention sets forth an agent for filling bone and tooth defects, for building up bone, for bone-contact layers and for the replacement of bones and the roots of teeth, which contains calcium phosphate apatite having carbonate and alkali portions, all ions being definedly integrated in the crystal lattice; use is optionally made together with additives and/or diluents both tolerated by the body. Furthermore, it sets forth the use of this apatite for filling bone and tooth defects, for building up bone, for bone-contact layers, as a replacement for bones and the roots of teeth and as an implant article consisting completely or partially of this apatite or consisting of a material known for implant articles and being coated completely or partially with a layer of this apatite.
102 Citations
25 Claims
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1. An agent for filling bone defects, for building up bone, for forming bone-contact layers on the replacements of bones and roots of teeth and for making independent smaller bone replacement parts or implant articles, comprising a calcium phosphate apatite having carbonate and alkali portions, all ions being definedly integrated in the crystal lattice, of the following formula:
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space="preserve" listing-type="equation">Ca.sub.10-a-b-x Me.sup.II.sub.a Me.sup.I.sub.b (PO.sub.4).sub.6-x (CO.sub.3).sub.x (OH).sub.2-b-x (H.sub.2 O).sub.wwherein MeI is a singly charged metal ion, MeII is a doubly charged metal ion, a represents the number of double charged metal ions with the exception of Ca and is a value from 0 to 1.0, b represents the number of singly charged metal ions and is a value from 0.05 to 1.2, x represents the number of carbonate ions and is a value from 0.02 to 1.2, the sum b+x being a maximum of 2.0, and w represents the number of water molecules integrated in the crystal lattice and is a value from 0 to b+x wherein at least a portion of the MeI ions are alkali ions and the CO3 ions are positioned at the PO4 positions within the apatite lattice. - View Dependent Claims (2, 3, 4, 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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6. A process for filling bone and tooth defects, for building up bone, for providing bone-contact layers, for bone replacement, or for tooth-root replacement comprising bringing into contact the affected region of bone or tooth with a material containing a calcium phosphate apatite having alkali and carbonate portions, in which all ions are definedly integrated in the crystal lattice, of the following formula:
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space="preserve" listing-type="equation">Ca.sub.10-a-b-x Me.sup.II.sub.a Me.sup.I.sub.b (PO.sub.4).sub.6-x (CO.sub.3).sub.x (OH).sub.2-b-x (H.sub.2 O).sub.wwherein MeI is a singly charged metal ion, MwII is a doubly charged metal ion, a represents the number of doubly charged metal ions with the exception of Ca and is a value from 0 to 1.0, b represents th number of singly charged metal ions and is a value from 0.05 to 1.2, x represents the number of carbonate ions and is a value from 0.2 to 1.2, the sum b+x being a maximum of 2.0, and w represents the number of water molecules integrated in the crystal lattice and is a value from 0 to b+x, wherein at least a portion of the MeI ions are alkali ions and the CO3 ions are positioned at the PO4 positions within the apatite lattice. - View Dependent Claims (7)
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8. An implant article containing calcium phosphate apatite having alkali and carbonate portions, all ions being definedly integrated in the crystal lattice, wherein the apatite has the formula:
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space="preserve" listing-type="equation">Ca.sub.10-a-b-x Me.sup.II.sub.a Me.sup.I.sub.b (PO.sub.4).sub.6-x (CO.sub.3).sub.x (OH).sub.2-b-x (H.sub.2 O).sub.wwherein MeI is a singly charged metal ion, MeII is a doubly charged metal ion, a represents the number of doubly charged metal ions with the exception of Ca and is a value from 0 to 1.0, b represents the number of singly charged metal ions and is a value from 0.05 to 1.2, x represents the number of carbonate ions and is a value from 0.2 to 1.2, the sum b+x being a maximum of 2.0, and w represents the number of water molecules integrated in the crystal lattice and is a value from 0 to b+x, wherein at least a portion of the MeI ions are alkali ions and the CO3 ions are positioned at the PO4 positions within the apatite lattice. - View Dependent Claims (9, 22, 23, 24, 25)
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Specification