Ventilation controlled rate responsive cardiac pacemaker

• US 4,919,136 A
• Filed: 09/28/1988
• Issued: 04/24/1990
• Est. Priority Date: 09/28/1987
• Status: Expired due to Term

• Current Assignee: Eckhard Alt
• Original Assignee: Eckhard Alt
• Inventors: Alt, Eckhard
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/250,060
• Time in Patent Office: 573 Days
• Field of Search: 128/734, 128/419 PG, 128/419 D, 128/723, 128/635, 128/697, 128/902
• US Class Current: 607/20
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36571 controlled by blood flow rate, e.g. blood velocity or cardiac output

Abstract

The rate of pacing pulses in a rate responsive pacemaker is controlled from data representing respiration characteristics in a patient detected by intracardiac impedance measurements for more reliable control. These measurements give more reliable data for the critical pacing pulse rate control then prior art impedance measurements within the human thorax, which necessarily detect impedance changes in various tissues following respiration activity. Thus the respiration produces opposite effects on variations of impedance of pulmonary tissue and of blood, which partially cancel each other and therefore compromise the validity of transthoracic impedance based measurements of respiration. Improved respiratory activity signals reducing the unwanted effects of the pulmonary impedance changes are obtained by measuring impedance strictly within the heart. The intracardiac impedance measurements are filtered through a low pass filter to isolate the ventilation activity where amplitude is related to the tidal volume. Nonlinearities of this amplitude signal related to the physioloical activity of a patient are found to be related inversely to the respiratory rate, and are accordingly corrected to provide control signals faithfully representing the true ventilatory tidal volume. Thus, ventilation signals representing tidal volume become a reliable factor for use in pacing pulse rate control.

Claims

1. Heart measurement instrumentation comprising in combination,

measurement means for producing a measurement signal responsive to intracardiac pressure and volume of a patient,

processing means for the measurement signal including means for isolating from the measurement signal separate ventilatory function signals displaying variable amplitude and respiratory rate related to respiratory activity of a patient, and

tidal volume detection means for processing the amplitude of the ventilatory function signals as a function of the respiratory rate to produce a corrected amplitude reflecting the true ventilatory tidal volume of the patient over a wide range of patient activity.

2. Instrumentation as defined in claim 1 further comprising:

pulse generator means for generating heart pacing pulses,

electrode means adapted to be located in the right heart for receiving the pacing pulses, and

pacer rate control means for controllably changing the rate of the heart pacing pulses in response to said corrected amplitude reflecting true ventilatory tidal volume.

3. Instrumentation as defined in claim 2, wherein said measuring means further comprises:

impedance measuring means responsive to intracardial impedance detected by said electrode means.

4. Instrumentation as defined in claim 3 further comprising:

common conveyance means for transmitting the pacing signals to the electrode means and receiving the measurement signals from the electrode means, and

means for preventing interference between measurement signals and pacing signals comprising means for inducing impedance measurements with periodic electric signals conveyed to the electrode of low enough energy that they are unable to pace the heart.

5. Instrumentation as defined in claim 4 further comprising:

low pass filter means for processing the measurement signals for isolating said ventilatory function signals from the measurement signals.

6. The instrumentation defined in claim 1 wherein said measurement means further comprises:

electrode means adapted to be implanted in a patient'"'"'s body for continually monitoring and analyzing intracardiac activity to produce said measurement signal and means responsive to a measurement signal component isolated by means of a low frequency filter representative of respiratory physiological variables for producing pacing pulses at said electrode means.

12. Instrumentation as defined in claim 1 wherein said measurement means comprises a single detection electrode consisting of a pacing electrode adapted to be located in the right side of the heart for receiving pacing pulses.

7. The method of controlling heart pacing rate of a patient in pacemaker systems, comprising the steps of:

implanting an electrode in the patient'"'"'s right heart,

providing periodic hear pacing pulses to the electrode,

sensing cardiac activity by monitoring intracardiac parameters presented to said electrode,

deriving from said cardiac activity a set of ventilatory signals representative of variable respiratory activity of the patient,

processing the ventilatory signals so as to derive subsignals representing respiratory rate and tidal volume,

modifying the tidal volume subsignal as a function of the respiratory rate subsignal so as to derive a pulse rate control algorithm, and

controlling the pacing rate as a function of said control algorithm.

8. The method of producing heart pacing rate signals comprising the steps of:

deriving signals responsive to exercise of a patient from intracardiac measurements reflecting volume and pressure,

separating from said intracardiac measurements separate ventilatory signals relating to a patient'"'"'s tidal volume and respiratory rate, and

deriving a corrected tidal volume signal reflecting the effect of exercise of the patient as a selected function of said signals from the intracardiac measurements.

9. The method of claim 8 wherein the selected function of intracardiac measurements is a respiratory rate signal derived from said signals from the intracardiac measurements.

10. The method of claim 8 further wherein the step of deriving signals responsive to exercise of a patient further comprises

sensing cardiac activity from a single electrode consisting of a pacing electrode adapted to be implanted in a patient to receive said pacing rate signals.

11. The method of claim 10 further wherein the step of deriving signals responsive to exercise of a patient further comprises measurement of impedance in the right side of the heart.