Ventilation controlled rate responsive cardiac pacemaker
First Claim
1. Heart measurement instrumentation comprising in combination,measurement means for producing a measurement signal responsive to intracardiac pressure and volume of a patient,processing means for the measurement signal including means for isolating from the measurement signal separate ventilatory function signals displaying variable amplitude and respiratory rate related to respiratory activity of a patient, andtidal volume detection means for processing the amplitude of the ventilatory function signals as a function of the respiratory rate to produce a corrected amplitude reflecting the true ventilatory tidal volume of the patient over a wide range of patient activity.
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Abstract
The rate of pacing pulses in a rate responsive pacemaker is controlled from data representing respiration characteristics in a patient detected by intracardiac impedance measurements for more reliable control. These measurements give more reliable data for the critical pacing pulse rate control then prior art impedance measurements within the human thorax, which necessarily detect impedance changes in various tissues following respiration activity. Thus the respiration produces opposite effects on variations of impedance of pulmonary tissue and of blood, which partially cancel each other and therefore compromise the validity of transthoracic impedance based measurements of respiration. Improved respiratory activity signals reducing the unwanted effects of the pulmonary impedance changes are obtained by measuring impedance strictly within the heart. The intracardiac impedance measurements are filtered through a low pass filter to isolate the ventilation activity where amplitude is related to the tidal volume. Nonlinearities of this amplitude signal related to the physioloical activity of a patient are found to be related inversely to the respiratory rate, and are accordingly corrected to provide control signals faithfully representing the true ventilatory tidal volume. Thus, ventilation signals representing tidal volume become a reliable factor for use in pacing pulse rate control.
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Citations
12 Claims
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1. Heart measurement instrumentation comprising in combination,
measurement means for producing a measurement signal responsive to intracardiac pressure and volume of a patient, processing means for the measurement signal including means for isolating from the measurement signal separate ventilatory function signals displaying variable amplitude and respiratory rate related to respiratory activity of a patient, and tidal volume detection means for processing the amplitude of the ventilatory function signals as a function of the respiratory rate to produce a corrected amplitude reflecting the true ventilatory tidal volume of the patient over a wide range of patient activity.
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7. The method of controlling heart pacing rate of a patient in pacemaker systems, comprising the steps of:
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implanting an electrode in the patient'"'"'s right heart, providing periodic hear pacing pulses to the electrode, sensing cardiac activity by monitoring intracardiac parameters presented to said electrode, deriving from said cardiac activity a set of ventilatory signals representative of variable respiratory activity of the patient, processing the ventilatory signals so as to derive subsignals representing respiratory rate and tidal volume, modifying the tidal volume subsignal as a function of the respiratory rate subsignal so as to derive a pulse rate control algorithm, and controlling the pacing rate as a function of said control algorithm.
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8. The method of producing heart pacing rate signals comprising the steps of:
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deriving signals responsive to exercise of a patient from intracardiac measurements reflecting volume and pressure, separating from said intracardiac measurements separate ventilatory signals relating to a patient'"'"'s tidal volume and respiratory rate, and deriving a corrected tidal volume signal reflecting the effect of exercise of the patient as a selected function of said signals from the intracardiac measurements. - View Dependent Claims (9, 10, 11)
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Specification