Method and compositions useful in preventing equine influenza
First Claim
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1. A recombinant DNA sequence encoding equine hemagglutinin H7 as depicted in FIG. 1.
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Accused Products
Abstract
Recombinant vaccines for immunizing horses against equine influenza virus (EIV) are disclosed. The DNA sequences encoding the hemagglutinin (HA) and neuraminidase (NA) glycoproteins from the two strains of EIV currently infective in horses are used to construct vaccinia carried vaccines, to design synthetic peptides for primer and booster administration, and to permit recombinant synthesis of HA and/or NA protein based vaccines. These DNA sequences also provide probes useful for preparing similar vaccines from fresh isolates of new strains generated by genetic drift.
101 Citations
2 Claims
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1. A recombinant DNA sequence encoding equine hemagglutinin H7 as depicted in FIG. 1.
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2. A recombinant DNA sequence encoding equine neuraminidase N7 as depicted in FIG. 3.
Specification
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Current AssigneeCalifornia Biotechnology, Inc. (Johnson & Johnson)
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Original AssigneeBiotechnology Research Partners, Ltd.
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InventorsDale, Beverly, Cordell, Barbara
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Primary Examiner(s)Teskin, Robin
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Application NumberUS06/888,250Time in Patent Office1,373 DaysField of Search435/68, 435/70, 435/172.3, 435/91, 435/235, 435/320, 435/238, 435/948, 435/235, 435/200, 435/201, 935/18, 935/12, 935/27, 935/65, 935/14, 536/27US Class Current536/23.72CPC Class CodesA61K 2039/5256 expressing foreign proteinsA61K 2039/552 Veterinary vaccineA61K 2039/55566 Emulsions, e.g. Freund's ad...A61K 2039/6081 Albumin; Keyhole limpet hae...A61K 39/12 Viral antigensA61K 39/145 Orthomyxoviridae, e.g. infl...C07K 14/005 from virusesC12N 2710/24143 viral genome or elements th...C12N 2760/16122 New viral proteins or indiv...C12N 2760/16134 Use of virus or viral compo...
