Method for determining a patient's blood sodium level and artificial kidney for the application thereof

• US 4,923,613 A
• Filed: 05/11/1988
• Issued: 05/08/1990
• Est. Priority Date: 05/15/1987
• Status: Expired due to Term

• Current Assignee: Industries Gambro
• Original Assignee: Hospal Industrie
• Inventors: Chevallet, Jacques
• Primary Examiner(s): Jones, W. Gary
• Application Number:
  US07/192,657
• Time in Patent Office: 727 Days
• Field of Search: 604/4-6, 210/85, 210/138, 210/143, 210/195.2, 210/321.65, 210/321.71, 210/321.72, 210/647, 210/929, 73/53, 73/61.1 R, 324/438, 324/439
• US Class Current: 210/647
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1607 before use, i.e. upstream of dialyser
• CPC Class Codes: A61M 1/1609 after use, i.e. downstream of dialyser
• CPC Class Codes: A61M 1/1617 using measurements made during a temporary variation of a characteristic of the fresh dialysis fluid
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3324 PH measuring means
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient

Abstract

A method for determining the blood sodium level of a patient whose blood circulates through one compartment of an exchanger separated from a dialysis fluid by a semipermeable membrane, wherein the conductivity of the dialysis fluid of equilibrium with the plasma is determined by: changing in a selected manner the conductivity of the dialysis fluid at inflow the exchanger, measuring the conductivity of the dialysis fluid at outflow from the exchanger, determining a lag time t_L of the change in conductivity of dialysis fluid between inflow to and outflow from the exchanger, and determining an equilibrium conductivity value of the dialysis fluid for which the conductivity at outflow from the exchanger at an instant t is equal to the conductivity at inflow at an instant t-t_L. The invention also relates to an artificial kidney incorporating means for carrying out this method.

Claims

1. A method for determining the blood sodium level of a patient whose blood circulates through a first compartment of an exchanger of an artificial kidney, said first compartment being separated from a second compartment of the exchanger by a semipermeable membrane for permitting dialysis and ultrafiltration of the blood, said second compartment being disposed in a dialysis fluid circuit through which dialysis fluid passes, comprising the steps of:

changing, in a selected manner, the conductivity of the dialysis fluid flowing into the second compartment of the exchanger;

measuring, in response to the step of changing the conductivity of the dialysis fluid, the change in conductivity of the dialysis fluid flowing out of the second compartment of the exchanger;

determining a lag time t_L between the change in conductivity of the dialysis fluid flowing into the second compartment of the exchanger and the corrresponding measured change in conductivity of dialysis fluid flowing out of the second compartment of the exchanger;

determining an equilibrium conductivity value of the dialysis fluid in the second compartment of the exchanger for which the conductivity of the dialysis fluid at outflow from the second compartment at a time t is substantially equal to the conductivity of the dialysis fluid at inflow into the second compartment at a time t'"'"'=t-t_L ; and

determining the sodium concentration in the patient'"'"'s blood in accordance with the determined equilibrium conductivity value.

2. The method according to claim 1, wherein the step of changing the conductivity of the dialysis fluid flowing into the second compartment of the exchanger includes the substep of:

increasing the conductivity of the dialysis fluid flowing into the second compartment in a predetermined manner.

3. The method of claim 1, wherein the step of changing the conductivity of the dialysis fluid flowing into the second compartment of the exchanger includes the substep of:

decreasing the conductivity of the dialysis fluid flowing into the second compartment in a predetermined manner.

4. The method of claims 2 or 3 wherein the conductivity of the dialysis fluid flowing into the second compartment of the exchanger is changed in a substantially continuous manner.

5. The method of claim 1, wherein the conductivity of the dialysis fluid is changed in a stepwise manner for a predetermined brief period of time beginning at time t_o, said lag time t_L then corresponding to the difference between the time t₀ and a time t₁ corresponding to initialization of the measured change in conductivity of dialysis fluid flowing out of the second compartment.

6. The method of claims 1, 2, or 3, wherein the step of determining the lag time t_L includes the substeps of:

determining a time to corresponding to the initialization of the change in conductivity of the dialysis fluid flowing into the second compartment of the exchanger;

monitoring, as a function of time, changes in the conductivity of the dialysis fluid flowing out of the second compartment to determine a time t₁ corresponding to the initialization of the change in conductivity of dialysis fluid flowing out of the second compartment;

determining the lag time t_L in accordance with the interval between times t_l and t_o.

7. The method of claims 1, 2, 3, or 5, wherein the artificial kidney includes a conductimeter positioned in the dialysis fluid circuit upstream of the second compartment of the exchanger relative to the flow of dialysis fluid in the dialysis fluid circuit, and wherein the method includes the further step of measuring, with the conductimeter, the conductivity of the dialysis fluid flowing into the second compartment.

8. The method of claims 1, 2, 3, or 5, wherein the artificial kidney includes a monitoring device including means for changing the conductivity of the dialysis fluid flowing into the second compartment in accordance with a predetermined pattern, and wherein the step of changing the conductivity of the dialysis fluid flowing into the second compartment includes the substep of monitoring, with the monitoring means, the predetermined pattern of the changing means to determine the conductivity of the dialysis fluid flowing into the second comparment of the exchanger.

9. A method for determining the blood sodium level of a patient'"'"'s blood circulating through a first compartment of an exchanger of an artificial kidney, said exchanger including a semipermeable membrane separating the first compartment from a second compartment of the exchanger through which dialysis fluid in a dialysis fluid circuit passes, said membrane being adapted to permit the dialysis and ultrafiltration of the blood from between the first and second compartments, comprising the steps of:

selectively changing the conductivity of dialysis fluid flowing into the second compartment of the exchanger;

monitoring the conductivity of the dialysis fluid flowing into the second compartment to determine a time t_o at which the conductivity of the dialysis fluid flowing into the second compartment changes in response to the step of selectively changing the conductivity;

monitoring the conductivity of the dialysis fluid flowing out of the second compartment to determine a time t_l at which the conductivity of the dialysis fluid flowing out of the second compartment changes in response to the step of selectively changing the conductivity;

determining a lag time t_L between initialization of the change in conductivity of the dialysis fluid flowing into and out of the second compartment in accordance with the difference between the times t₀ and t₁ ;

determining an equilibrium value between the conductivity of the dialysis fluid in the second compartment and the conductivity of the blood in the first compartment in accordance with the monitored values of conductivity of the dialysis fluid and the lag time t_L ; and

determining the patient'"'"'s blood sodium level in accordance with the determined equilibrium conductivity value.

10. The method of claim 9, wherein the step of determining an equilibrium value of conductivity includes the substep of:

determining a value of conductivity of the dialysis fluid flowing out the second compartment at a time t₃ which conductivity value is substantially equal to a value of conductivity of the dialysis fluid flowing into the second compartment at a time t_2=t3 -t_L, said conductivity value of the dialysis fluid at the times t₂ and t₃ substantially corresponding to the equilibrium value of conductivity of the patient'"'"'s blood and the dialysis fluid.

11. An artificial kidney including an exchanger having at least first and second compartments separated by a semipermeable membrane for permitting the dialysis and ultrafiltration of the blood therethrough, said first compartment being disposed in an extracorporeal blood circuit and said second compartment having an inlet and an outlet for flow communicating with a dialysis fluid circuit having dialysis fluid flowing therethrough, comprising:

means for selectively changing the conductivity of the dialysis fluid flowing into said second compartment through said inlet;

means for measuring the conductivity of the dialysis fluid flowing out of said second compartment through said outlet;

means for determining a lag time t_L between a change in conductivity of the dialysis fluid flowing into said second compartment and a corresponding change in conductivity of the dialysis fluid flowing out of said second compartment;

means for determining an equilibrium conductivity value of the dialysis fluid relative to the blood for which value the conductivity of the dialysis fluid at outflow from said second compartment at an instant t is equal to the conductivity of the dialysis fluid at inflow to said second compartment at an instant t'"'"'=t-t_L.

12. The artificial kidney of claim 11, including means for monitoring the conductivity of the dialysis fluid flowing into said second compartment.

13. The artificial kidney of claims 11 or 12, including means for determining a value of the blood sodium level in accordance with said equilibrium conductivity value of the dialysis fluid and the blood.

14. The artificial kidney of claims 11 or 12, wherein said means for determining the lag time t_L, and said means for determining the equilibrium conductivity value of the dialysis fluid and the blood comprise a microcontroller.

15. The artificial kidney of claim 13, wherein said means for determining a value of the blood sodium level comprises a microcontroller.