Angioplastic method for removing plaque from a vas

• US 4,924,863 A
• Filed: 05/04/1988
• Issued: 05/15/1990
• Est. Priority Date: 05/04/1988
• Status: Expired due to Term

• Current Assignee: MMTC Limited (Government of India)
• Original Assignee: MMTC Limited (Government of India)
• Inventors: Sterzer, Fred
• Primary Examiner(s): Hindenburg, Max
• Application Number:
  US07/190,179
• Time in Patent Office: 741 Days
• Field of Search: 128/303.1, 128/395-398, 604/96, 604/101, 604/102
• US Class Current: 606/27
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61B 2017/22021 electric leads passing through the catheter
• CPC Class Codes: A61B 2017/22052 eccentric
• CPC Class Codes: A61B 2018/00232 having an irregular shape
• CPC Class Codes: A61B 2090/3933 Liquid markers
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/123 using a flexible balloon containing the thermal element

Abstract

Fatty artherosclerotic plaque, under heat (e.g. by applied microwave radiation) and pressure, is liquified and sucked into the interior of one of two catheters of a catheter arrangement through an aperture therein and then sucked out of a patient'"'"'s body through the proximal end of the one catheter. The other of the two catheters employs an inflated balloon to press the aperture region of the one catheter firmly against the plaque portion to be removed. Calcified artherosclerotic plaque can be ablated and removed in a similar manner, by substituting ultrasonic energy for heat.

Claims

1. A transluminal balloon angioplastic method for removing at least a portion of fatty artherosclerotic plaque initially in non-removable form that partially occludes the lumen of a vas, thereby to increase the size of the lumen;

said method comprising the steps of;

(a) inserting into said vas a catheter arrangement having;

(1) a deflated balloon disposed off-center of the longitudinal axis of said catheter arrangement in a first sidewall of said catheter arrangement, said deflated balloon being located at a given longitudinal position situated toward the distal end of said catheter arrangement;

(2) an aperture disposed off-center of the longitudinal axis of said catheter arrangement in a second sidewall of said catheter arrangement that is located substantially opposite to said first sidewall, said aperture being located substantially at said given longitudinal position; and

(3) means for preventing gas from entering said vas through said aperture while said balloon is deflated;

(b) positioning said catheter arrangement so that said aperture is in proximity to the fatty artherosclerotic plaque which includes said portion to be removed;

(c) inflating said balloon so that said balloon presses against a part of a wall of said vas located substantially opposite to the fatty artherosclerotic plaque which includes said portion to be removed, thereby causing said aperture to be pressed against the fatty artherosclerotic plaque that includes said portion to be removed with a first pressure that provides sufficient firmness to prevent any fluid in said vas from entering the interior of said catheter arrangement through said aperture while said balloon is inflated;

(d) while said balloon is inflated, applying heat energy for a limited time to the fatty artherosclerotic plaque which includes said portion to be removed, which applied heat energy raises the temperature of the fatty artherosclerotic plaque under said first pressure to a value which is sufficient to cause at least a portion thereof to liquify and rise to the surface of the plaque then in contact with said aperture, but which temperature is insufficient to cause death of underlying tissue of said vas; and

(e) while said balloon is inflated, applying sufficient suction to the interior of said catheter arrangement to reduce the relative pressure within the interior of said catheter arrangement in the vicinity of said aperture to a second pressure to cause said liquified plaque portion being sucked into the interior of said catheter arrangement through said aperture and then being sucked out of said catheter arrangement at the proximal end thereof.

2. The angioplastic method defined in claim 1, further including the following step:

(f) subsequent to the completion of steps (d) and (e), deflating said balloon and then removing said catheter arrangement from said vas.

3. The angioplastic method defined in claim 2, further including the following step:

(g) subsequent to the completion of steps (d) and (e), terminating the application of said heat energy.

4. The angioplastic method defined in claim 1, wherein:

step (a) comprises inserting into said vas a catheter arrangement comprised of first and second juxtaposed catheters attached to one another along said longitudinal axis, only said first catheter including said balloon and only said second catheter including said aperture, said balloon and said aperture being situated substantially diametrically opposite to one another;

step (c) comprises filling solely the interior of said first catheter with a liquid to inflate said balloon; and

step (e) comprises applying suction soley to the interior of said second catheter.

5. The angioplastic method defined in claim 1, wherein:

said heat energy defined in step (d) is dielectrically generated within said fatty artherosclerotic plaque by microwave or radio frequency energy applied thereto.

6. The angioplastic method defined in claim 5;

wherein;

step (a) comprises inserting into said vas a catheter arrangement comprised of first and second juxtaposed catheters attached to one another along said longitudinal axis, only said first catheter including said balloon and only said second catheter including said aperture, and said second catheter also including in the interior thereof (1) an antenna situated in proximity to said aperture for raidating microwave or radio-frequency energy into said fatty artherosclerotic plaque and (2) a transmission line coupled to said antenna and extending to the proximate end of said second catheter for applying microwave or radio-frequency energy to said antenna.

7. The angioplastic method defined in claim 1, wherein:

said predetermined type of energy defined in step (d) is ultrasonic energy in a sufficient amount to cause calcified artherosclerotic plaque material to be ablated at the surface thereof in contact with said aperture when said aperture is pressed against the plaque as defined in step (c), said ablated calcified artherosclerotic material constituting plaque in a removable form.

8. The angioplastic method defined in claim 7, wherein:

step (a) comprises inserting into said vas a catheter arrangement comprised of first and second juxtaposed catheters attached to one another along said longitudinal axis, only said first catheter including said balloon and only said second catheter including said aperture, and said second catheter also including in the interior thereof (1) an ultrasonic transducer in proximity to said aperture for radiating ultrasonic energy onto said calcified artherosclerotic plaque, and (2) a transmission line coupled to said ultrasonic transducer and extending to the proximate end of said second catheter for applying ultrasonic-frequency electrical energy to said ultrasonic transducer.