Technetium -99m complex for examining the renal function
First Claim
1. Technetium-99m complex of the general formula ##STR6## wherein Z is an amino group of the general formula R17 --N--(R18)k, in which k is 0 or 1 and R17 and R18 have the same meanings as the symbols R1 -R16 is individually selected from the group consisting of hydrogen, straight or branched, unsubstituted or substituted alkyl having 1-4 carbon atoms, and ACOOH, wherein A is a straight or branched, unsubstituted or substituted alkyl group having 0-4 carbon atoms;
- and R5 together with R6 or R9 together with R10 additionally may form an oxygen atom;
Tc represents technetium-99m;
t is 0 or 1; and
n is 0 or 1;
with the provisos that(a) if at least one of R15, R16, R17 and R18 is ACOOH, A is a straight or branched, unsubstituted or substituted alkyl group having 1-4 carbon atoms;
(b) at least one of the symbols R1 -R18 is ACOOH; and
(c) if t is 1, at least two of the symbols R1 -R18 are ACOOH;
or a pharmaceutically acceptable salt of this compound.
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Accused Products
Abstract
The invention relates to a technetium-99m complex of the general formula ##STR1## wherein Z is a sulphur atom or an amino group of the general formula R17 --N--(R18)k, in which k is 0 or 1 and R17 and R18 have the same meanings as the symbols R1 -R16 ;
each of the symbols R1 -R16 is individually selected from the group consisting of hydrogen, straight or branched, unsubstituted or substituted alkyl having 1-4 carbon atoms, and ACOOH, wherein A is a straight or branched, unsubstituted or substituted alkly group having 0-4 carbon atoms;
and R5 together with R6 or R9 together with R10 additionally may form an oxygen atom;
Tc represents technetium-99m;
t is 0 or 1; and
n is 0 or 1;
with the provisos that
(a) if R15, R16, R17 and/or R18 are/is ACOOH, A is a straight or branched, unsubstituted or substituted alkyl group having 1-4 carbon atoms;
(b) at least one of the symbols R1 -R18 is ACOOH; and
(c) if t is 1, at least two of the symbols R1 -R18 are ACOOH;
or a pharmaceutically acceptable salt of this compound.
The invention further relates to a radiopharmaceutical composition comprising said complex, to the use of this composition for examining the renal function, and to a kit for preparing such a composition.
64 Citations
15 Claims
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1. Technetium-99m complex of the general formula ##STR6## wherein Z is an amino group of the general formula R17 --N--(R18)k, in which k is 0 or 1 and R17 and R18 have the same meanings as the symbols R1 -R16 is individually selected from the group consisting of hydrogen, straight or branched, unsubstituted or substituted alkyl having 1-4 carbon atoms, and ACOOH, wherein A is a straight or branched, unsubstituted or substituted alkyl group having 0-4 carbon atoms;
- and R5 together with R6 or R9 together with R10 additionally may form an oxygen atom;
Tc represents technetium-99m; t is 0 or 1; and n is 0 or 1; with the provisos that (a) if at least one of R15, R16, R17 and R18 is ACOOH, A is a straight or branched, unsubstituted or substituted alkyl group having 1-4 carbon atoms; (b) at least one of the symbols R1 -R18 is ACOOH; and (c) if t is 1, at least two of the symbols R1 -R18 are ACOOH; or a pharmaceutically acceptable salt of this compound. - View Dependent Claims (2, 3, 4, 5)
- and R5 together with R6 or R9 together with R10 additionally may form an oxygen atom;
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6. Technetium-99m complex of the general formula ##STR8## wherein Z is a sulphur atom or an amino group of the general formula R17 --N--(R18)k,
in which K is 0 or 1 and R17 and R18 have the same meanings as the symbols R1 -R16 ; -
each of the symbols R1 -R16 is individually selected from the group consisting of hydrogen, straight or branched, unsubstituted or substituted alkyl having 1-4 carbon atoms, and ACOOH, wherein A is a straight or branched, unsubstituted or substituted alkyl group having 0-4 carbon atoms; and R5 together with R6 or R9 together with R10 additionally may form an oxygen atom; Tc represents technetium-99m; t is 0 or 1; n is 0 or 1; with the proviso that at least two of the symbols R1 -R18 are ACOOH, wherein A is a straight or branched unsubstituted or substituted alkyl group having 1-4 carbon atoms, or a pharmaceutically acceptable salt of this compound. - View Dependent Claims (7, 8, 9, 10)
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11. Technetium-99m complex of the general formula ##STR10## wherein Z is a sulphur atom or an amino group of the general formula R17 --N--(R18)k,
in which k is 0 or 1 and R17 and R18 have the same meanings as the symbols R1 -R16 ; -
each of the symbols R1 -R16 is individually selected from the group consisting of hydrogen, straight or branched, unsubstituted or substituted alkyl having 1-4 carbon atoms, and COOH; and R5 together with R6 or R9 together with R10 additionally may form an oxygen atom; Tc represents technetium-99m; t is 0 or 1; and n is 0 or 1; with the provisos that (a) at least one of the symbols R1 -R18 is COOH; and
(b) if t is 1, at least two of the symbols R1 -R18 are COOH,or a pharmaceutically acceptable salt of this compound. - View Dependent Claims (12, 13, 14, 15)
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Specification