CO.sub.2 diagnostic monitor

• US 4,928,687 A
• Filed: 10/11/1988
• Issued: 05/29/1990
• Est. Priority Date: 10/11/1988
• Status: Expired due to Fees

• Current Assignee: University of Florida (State University System of Florida)
• Original Assignee: University of Florida (State University System of Florida)
• Inventors: Gravenstein, Nikolaus, Lampotang, Samsun, Gravenstein, Dietrich, Banner, Michael J., Gravenstein, Joachim S.
• Primary Examiner(s): Burr, Edgar S.
• Assistant Examiner(s): Lewis, Aaron J.
• Application Number:
  US07/255,400
• Time in Patent Office: 595 Days
• Field of Search: 128/207.14, 128/716, 128/719, 128/204.22, 128/205.23, 128/200.26, 436/133, 422/86
• US Class Current: 128/207.14
• CPC Class Codes: A61M 16/0488 Mouthpieces; Means for guiding, securing or introducing the tubes guiding or introducing with laryngoscopes A61B1/267; holding devices on the body A61M25/02
• CPC Class Codes: A61M 2016/0413 with detectors of CO2 in exhaled gases
• CPC Class Codes: A61M 2230/432 partial CO2 pressure (P-CO2)

Abstract

A diagnostic monitor checks the carbon dioxide (CO₂) content of a gas exiting a patient during endotracheal or esophageal intubation. A plurality of composition portions substantially change color in response to exposure to the carbon dioxide. The composition portions change color in response to different times of exposure to carbon dioxide. A magnifying or condensing lens may be positioned on the monitor to enhance viewing of the color change. The monitor may advantageously be made as part of an intubation system through which the gases from a patient exit the patient. The differences in time of exposure needed to cause the color change may be accomplished by using semipermeable membranes having differing thicknesses, CO₂ permeabilities, and/or surface areas with each membrane corresponding to a particular one of the composition portions.

Claims

1. A self-contained diagnostic monitor for screening the CO₂ content of a gas exiting a patient during endotracheal or esophageal intubation comprising:

(1) a reservoir containing at least one portion of a composition having an initial pH in solution above about 3.8 and which substantially changes color in solution in response to exposure to CO₂, said reservoir having an opening adapted for communication only with said gas exiting and entering said patient during endotracheal or esophageal intubation; and

(2) a semipermeable membrane which is permeable to CO₂, said membrane separating said at least one composition portion from said exiting and entering gases, and wherein said reservoir contains a plurality of composition portions having initial pH is solution above about 3.8 and which substantially change color in solution in response to exposure to CO₂, and further comprising a plurality of semi-permeable membranes having differing thicknesses and/or CO₂ permeabilities and/or surface areas, each semi-permeable membrane separating a corresponding composition portion from said exiting and said entering gas, and each one of said plurality of composition portions separated from every other composition portion by at least one semi-permeable membrane, and each of said plurality of composition portions requiring a different time of exposure to CO₂ to effect said change in pH thereby causing said color change.

2. The monitor of claim 1 wherein said reservoir is constructed substantially of a substantially transparent material for exteriorly viewing said color change in said at least one composition.

3. The monitor of claim 1 wherein said composition contains a solid inert substrate having a construction which enhances the viewing of said color change and maintains the dimensions of said at least one composition substantially constant irrespective of the orientation of said reservoir.

4. The monitor of claim 1 wherein each of said plurality of compositions has a different initial pH.

5. The monitor of claim 1 wherein each of said plurality of compositions is separated from said exiting gas by semipermeable membranes having differing thicknesses and/or CO₂ permeabilities and/or surface areas.

6. The monitor of claim 1 wherein said at least one composition is a liquid and said monitor is sealed in a fluid tight, removable wrapper to prevent dessication of said at least one composition prior to use thereof in said intubation.

7. The monitor of claim 1 wherein said at least one composition is non-liquid and said reservoir contains means for holding a liquid solvent separate from said dry composition and for introducing the liquid solvent to said composition prior to or during said intubation.

8. The monitor of claim 1 having a magnifying or condensing lens positioned thereon to enhance viewing of said color change.

9. The monitor of claim 1 wherein said at least one composition is a buffered solution of bromothymol blue and phenolphthalein.

10. In an endotracheal or esophageal intubation system containing means through which gases exit the patient during said intubation, the improvement comprising a self-contained diagnostic monitor for screening the CO₂ content of a gas exiting said patient during said intubation comprising:

(1) a reservoir containing at least one portion of a composition having an initial pH in solution above about 3.8 and which substantially changes color in solution in response to exposure to CO₂, said reservoir having an opening adapted for communication only with said gases exiting and entering during said intubation; and

(2) a semipermeable membrane which is permeable to CO₂, said membrane separating said at least one composition portion from said exiting and entering gases, and wherein said reservoir contains a plurality of composition portions having initial pH in solution above about 3.8 and which substantially change color in solution in response to exposure to CO₂, and further comprising a plurality of semi-permeable membranes having differing thicknesses and/or CO₂ permeabilities and/or surface areas, each semi-permeable membrane separating a corresponding composition portion from said exiting and said entering gas, and each one of said plurality of composition portions separated from every other composition portion by at least one semi-permeable membrane, and each of said plurality of composition portions requiring a different time of exposure to CO₂ to effect said change in pH thereby causing said color change.

11. The system of claim 10 wherein said reservoir is constructed substantially of a substantially transparent material for exteriorly viewing said color change in said at least one composition.

12. The system of claim 10 wherein said composition contains a solid inert substrate having a construction which enhances the viewing of said color change and maintains the dimensions of said at least one composition substantially constant irrespective of the orientation of said reservoir.

13. The sytem of claim 10 wherein each of said plurality of compositions has a different initial pH.

14. The system of claim 10 wherein each of said plurality of compositions is separated from said exiting gases by semipermeable membranes having differing thicknesses and/or CO₂ permeabilities and/or surface areas.

15. The system of claim 10 wherein said at least one composition is a liquid and said monitor is sealed in a fluid tight, removable wrapper to prevent dessication of said at least one composition prior to use thereof in said intubation.

16. The system of claim 10 wherein said at least one composition is non-liquid and said reservoir contains means for introducing a liquid solvent to said composition prior to or during said intubation.

17. The system of claim 10 having a magnifying or condensing lens positioned thereon to enhance viewing of said color change.

18. The monitor of claim 10 wherein said at least one composition is a buffered solution of bromothymol blue and phenolphthalein.

19. The system of claim 11 wherein said means through which said gases exit said patient is an elongated esophageal cannula having a distal end adapted for insertion into the esophagus of said patient, said opening in said reservoir of said monitor communicating with said exiting gases via an opening in the proximal end of said cannula.

20. The system of claim 19 wherein said respective openings in said reservoir and said proximal end of said cannula form a seal which is substantially fluid tight with respect to the ambient temperature.

21. In a method for monitoring the CO₂ content of gases exiting a patient during endotracheal or esophageal intubation, the improvement comprising providing a self-contained CO₂ diagnostic monitor and contacting said exiting gases with said monitor, the monitor having a reservoir containing a plurality of composition portions having an initial pH solution above about 3.8 and which substantially changes color in solution in response to CO₂, said reservoir having an opening adapted for communication only with said entering and exiting gases during said intubation, each composition portion separated from other composition portions and each composition portion requiring a different time of exposure to CO₂ to effect said change in pH thereby causing said color change;

a plurality of semipermeable membranes having differing thicknesses and/or CO₂ permeabilities and/or surface areas, each semi-permeable membrane permeable to CO₂ and separating a corresponding one of said composition portions from said entering and exiting gases; and

viewing said plurality of composition portions.

22. The method of claim 21 wherein said reservoir is constructed substantially of a substantially transparent material for exteriorly viewing said color change in said at least one composition.

23. The method of claim 21 wherein said composition contains a solid inert substrate having a construction which enhances the viewing of said color change and maintains the dimensions of said at least one composition substantially constant irrespective of the orientation of said reservoir.

24. The method of claim 21 wherein each of said plurality of compositions has different initial pH.

25. The method of claim 21 wherein each of said plurality of compositions is separated from said exiting gases by semipermeable membranes having different thicknesses and/or CO₂ permeabilities and/or surface areas.

26. The method of claim 21 wherein said at least one composition is a liquid and said monitor is sealed in a fluid tight, removable wrapper to prevent dessication of said at least one composition prior to use thereof in said intubation.

27. The method of claim 21 wherein said at least one composition is non-liquid and said reservoir contains means for introducing a liquid solvent to said composition prior to or during said intubation.

28. The method of claim 21 having a magnifying or condensing lens positioned thereon to enhance viewing of said color change.

29. The method of claim 21 wherein said at least one composition is a buffered solution of bromothymol blue and phenolphthalein.

30. In an endotracheal intubation system containing means through which gases exit the patient during said intubation, the improvement comprising a self-contained diagnostic monitor for screening the CO₂ content of a gas exiting said patient during said intubation comprising:

(1) a reservoir containing at least one portion of a composition having an initial pH in solution above about 3.8 and which substantially changes color in solution in response to exposure to CO₂, said reservoir having an opening adapted for communication only with said gases exiting and entering during said intubation; and

(2) a semipermeable membrane which is permeable to CO₂, said membrane separating said at least one composition from said exiting and entering gases, said system further comprising an endotracheal tube, and wherein said monitor is a part of the endotracheal tube and wherein said reservoir contains a plurality of composition portions having an initial pH in solution above about 3.8 and which substantially change color in solution in response to exposure to CO₂ and further comprising a plurality of semi-permeable membranes having differing thicknesses and/or CO₂ permeabilities and/or surface areas, each semi-permeable membrane separating a corresponding composition portion from said exiting and said entering gas, and each one of said plurality of composition portions separated from every other compositions portion by at least one semi-permeable membrane, and each of said plurality of composition portions requiring a different time of exposure to CO₂ to effect said change in pH thereby causing said color change.