Implantable fluid imbibing pump with improved closure

• US 4,929,233 A
• Filed: 08/26/1988
• Issued: 05/29/1990
• Est. Priority Date: 08/26/1988
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Roth, Nathan, Yum, Su I.
• Primary Examiner(s): LUCAS, SUSAN J
• Application Number:
  US06/236,974
• Time in Patent Office: 641 Days
• Field of Search: 604/131, 604/892.1, 215/320, 220/306
• US Class Current: 604/131
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 5/1483 using flexible bags externally pressurised by fluid pressure

Abstract

An improved imbibing agent dispenser having a snap-on closure which is highly reliable, is simple to assemble on one end of the agent dispenser, and can be made at minimum expense without requiring heat or an adhesive to bond the closure to the dispenser. The closure is held in place on the dispenser by a locking feature formed by a shoulder on the end of the dispenser and a ledge on an outer, annular wall of the closure, the ledge being removably hooked beneath and biased toward the shoulder to releasably lock the closure to the dispenser. An important aspect of this closure is that the design provides for the complete containment of a solute component within the dispenser.

Claims

1. In an osmotically driven agent dispenser including an inner flexible bag adapted to contain the agent and having an open end, an intermediate layer of an osmotically effective solute composition at least partly encapsulating the bag, an outer shape-retaining membrane encapsulating the layer of osmotically effective solute composition, said membrane being at least in part permeable to water, and a port that extends from the interior of the bag to the exterior of the dispenser through which the agent may be charged into the bag and dispensed from the bag, the improvement comprising a locking snap-on closure for closing the open end of the bag, the closure having a biasing member for sealingly engaging the open end of the bag and a locking means preventing removal of the closure when the closure is in sealing engagement with the open end of the bag.

2. The agent dispenser as set forth in claim 1, wherein the agent is a fluid.

3. The agent dispenser as set forth in claim 1, wherein the closure comprises two biasing members for receiving the open end of the bag therebetween, the biasing members being resilient and biased toward one another.

4. The agent dispenser as set forth in claim 1, wherein the locking means comprises a ledge on the biasing member, the ledge adapted for underlying a shoulder on the outer shape-retaining membrane when the open end of the bag is placed in sealing relation with the closure.

5. The agent dispenser as set forth in claim 1, wherein the closure includes an inner biasing member and an outer biasing member, the inner biasing member including a wall having a central recess therein, the closure further including a plug receivable in the central recess and biasing the wall toward the outer biasing member.

6. The agent dispenser as set forth in claim 5, wherein the plug is comprised of a resilient material.

7. The agent dispenser as set forth in claim 5, wherein the wall has a taper, the outer surface of the plug being tapered and complemental to the taper of the wall.

8. The agent dispenser as set forth in claim 5, including a web on the inner biasing member for defining an inner boundary of the central recess, the web being integral with the wall, the agent charging and dispensing port extending through the web and the plug.

9. The agent dispenser as set forth in claim 6, wherein the plug has an outer surface provided with additional locking means thereon.

10. The agent dispenser as set forth in claim 9, wherein the additional locking means includes a plurality of spaced annular ribs.

11. The agent dispenser as set forth in claim 10, wherein each rib has a convex outer surface.

12. The agent dispenser as set forth in claim 10, wherein each rib has a sawtooth transverse cross section.

13. The agent dispenser as set forth in claim 5, wherein the closure includes a resilient flange connecting the inner and outer biasing members.

14. In an osmotically driven fluid dispenser comprising an inner flexible bag adapted to contain the fluid, an intermediate layer of an osmotically effective solute composition at least partly encapsulating the bag, an outer, generally rigid membrane casing encapsulating the layer of osmotically effective solute composition, said membrane being at least in part permeable to water, and a port that extends from the interior of the bag to the exterior of the dispenser through which the fluid may be charged into the bag and dispensed from the bag, the improvement comprising a snap-on closure for closing the open end of the bag, the closure having inner and outer biasing members for receiving and sealing the open end of the bag therebetween and a locking means preventing removal of the closure when the closure is in sealing engagement with the open end of the bag.

15. The fluid dispenser as set forth in claim 14, wherein the inner and outer biasing members have a space therebetween for receiving the open ends of the bag and the membrane.

16. The fluid dispenser as set forth in claim 14, wherein the members are resilient and are biased toward each other.

17. The fluid dispenser as set forth in claim 14, wherein the locking means comprises a ledge on one of the biasing members and a shoulder on the membrane casing, said ledge engaging the shoulder to lock the closure onto the casing.

18. The fluid dispenser as set forth in claim 14, wherein the inner biasing member includes a wall having a central recess therein, the closure further including a plug receivable in the central recess and biasing the inner wall outwardly toward the outer biasing member.

19. The fluid dispenser as set forth in claim 18, wherein the plug is comprised of a resilient material.

20. The fluid dispenser as set forth in claim 18, wherein the wall has a taper, the outer surface of the plug being tapered and complemental to the taper of the wall.

21. The fluid dispenser as set forth in claim 18, including a web for defining an inner boundary of the central recess, the web being integral with the wall, the charging and dispensing port extending through the web and the plug.

22. The fluid dispenser as set forth in claim 19, wherein the plug has an outer surface provided with additional locking means thereon.

23. The fluid dispenser as set forth in claim 22, wherein the additional locking means includes a plurality of spaced annular ribs.

24. The fluid dispenser as set forth in claim 23, wherein each rib has a convex outer surface.

25. The fluid dispenser as set forth in claim 23, wherein each rib has a sawtooth cross section.

26. The fluid dispenser as set forth in claim 14, wherein the closure includes a resilient flange connecting the inner and outer biasing members.