Tetrahydropyridine oxime compounds
First Claim
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1. A compound having the formula ##STR12## wherein R1 is selected from hydrogen;
- straight or branched alkyl of from one to six carbon atoms unsubstituted or substituted with hydroxy or alkoxy of from one to four carbon atoms;
straight or branched alkenyl of from two to six carbon atoms unsubstituted or substituted with hydroxy or alkoxy of from one to four carbon atoms;
straight or branched alkynyl of from two to six carbon atoms unsubstituted or substituted with hydroxy or alkoxy of from one to four carbon atoms;
##STR13## where A is a bond or is a hydrocarbon chain of from one to four carbon atoms, unsubstituted or substituted with halogen, and when containing two or more carbon atoms may contain one double bond and R3 is alkyl of from one to six carbon atoms;
or ##STR14## where n is zero, two, three or four and X and Y are independently selected fromhydrogen,fluorine,chlorine,bromine,hydroxy,straight or branched alkyl of from one to three carbon atoms, oralkoxy of from one to four carbon atoms;
orR2 is selected from;
straight or branched alkynyl of from two to six carbon atoms unsubstituted or substituted with hydroxy or alkoxy of from one to four carbon atoms;
##STR15## where n is zero to six and X and Y are independently selected fromhydrogen,fluorine,chlorine,bromine,hydroxy,straight or branched alkyl of from one to three carbon atoms, or alkoxy of from one to four carbon atoms;
with the proviso that R1 and R2 may not both simultaneously be hydrogen;
or a pharmaceutically acceptable salt thereof.
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Abstract
Certain N-substituted 1-(1,2,3,6-tetrahydro-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)oximes are useful as sigma binding agents for the treatment of depression, psychoses and/or inflammatory diseases.
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Citations
6 Claims
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1. A compound having the formula ##STR12## wherein R1 is selected from hydrogen;
- straight or branched alkyl of from one to six carbon atoms unsubstituted or substituted with hydroxy or alkoxy of from one to four carbon atoms;
straight or branched alkenyl of from two to six carbon atoms unsubstituted or substituted with hydroxy or alkoxy of from one to four carbon atoms; straight or branched alkynyl of from two to six carbon atoms unsubstituted or substituted with hydroxy or alkoxy of from one to four carbon atoms;
##STR13## where A is a bond or is a hydrocarbon chain of from one to four carbon atoms, unsubstituted or substituted with halogen, and when containing two or more carbon atoms may contain one double bond and R3 is alkyl of from one to six carbon atoms;
or ##STR14## where n is zero, two, three or four and X and Y are independently selected fromhydrogen, fluorine, chlorine, bromine, hydroxy, straight or branched alkyl of from one to three carbon atoms, or alkoxy of from one to four carbon atoms;
orR2 is selected from;
straight or branched alkynyl of from two to six carbon atoms unsubstituted or substituted with hydroxy or alkoxy of from one to four carbon atoms;
##STR15## where n is zero to six and X and Y are independently selected fromhydrogen, fluorine, chlorine, bromine, hydroxy, straight or branched alkyl of from one to three carbon atoms, or alkoxy of from one to four carbon atoms; with the proviso that R1 and R2 may not both simultaneously be hydrogen;
or a pharmaceutically acceptable salt thereof. - View Dependent Claims (2, 3, 4, 5, 6)
- straight or branched alkyl of from one to six carbon atoms unsubstituted or substituted with hydroxy or alkoxy of from one to four carbon atoms;
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Current AssigneeWarner-Lambert Company (Pfizer Inc.)
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Original AssigneeWarner-Lambert Company (Pfizer Inc.)
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InventorsDavis, Robert E., Tecle, Haile, Moos, Walter H., Meltzer, Leonard T., Moreland, David W., Heffner, Thomas G., Downs, David A., Coughenour, Linda L.
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Primary Examiner(s)Lee, Mary C.
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Assistant Examiner(s)Northington-Davis, Zinna
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Application NumberUS07/259,081Time in Patent Office588 DaysField of Search546/338, 514/357US Class Current546/338CPC Class CodesA61K 31/44 Non condensed pyridines; Hy...C07D 211/70 with only hydrogen atoms, h...
