Technique to evaluate myocardial ischemia from ECG parameters

• US 4,930,075 A
• Filed: 06/06/1988
• Issued: 05/29/1990
• Est. Priority Date: 07/13/1987
• Status: Expired due to Fees

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Inventors: Kortas, Ricardo G.
• Primary Examiner(s): SMITH, JERRY
• Assistant Examiner(s): Meyer, Charles B.
• Application Number:
  US07/221,798
• Time in Patent Office: 722 Days
• Field of Search: 364/413.06, 364/413.05, 364/413.01, 435/637, 435/17, 128/702, 128/711, 128/904, 128/700, 128/703
• US Class Current: 600/509
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/358 Detecting ST segments

Abstract

As a method of diagnosing ischemia non-invasively, the effective component of the ST-segment depression (STe) of an electrocardiogram is measured. A precise mathematical relationship between the values of the ST-segment depression, slope, and length of the ST-segment was defined and implemented, making it possible to compare any ST-segment morphology against a standard reference of horizontal depression.

Claims

1. A method of evaluating a patient for ischemia by evaluation of an electrocardiogram of that patient and specifically an ST segment thereof, comprising the steps of taking an electrocardiogram of the patient, digitizing the electrocardiogram, determine length of said ST segment, estimating a critical threshold value in said electrocardiogram as a function of the length of the ST-segment of said electrocardiogram, calculating a value representing ST-segment depression relative to a fixed baseline based on signal information representing said baseline and said ST-segment to transform signals representing the ST-segment morphology into signals representing an equivalent horizontal morphology, and comparing said signals representing said equivalent horizontal morphology to said threshold value, where morphologies exceeding said threshold are labelled ischemic.

2. A signal processing system for evaluating and assigning a patient to normal or ischemic categories comprising means for generating a digital representation of an electrocardiogram of said patient, means for analyzing said electrocardiogram and calculating a critical threshold value for said electrocardiogram as a function of the length of the ST-segment of said electrocardiogram, means for calculating a value representing ST-segment depression relative to a fixed baseline based on said digitized signal information representing said baseline and said ST-segment to transform signals representing the ST-segment morphology into signals representing an equivalent horizontal morphology, comparison means for comparing said signals representing said horizontal morphology to signals representing said threshold value and assigning said patient to a normal or ischemic classification based on the result of said comparison.

3. A system as in claim 2 wherein said ST-segment is measured extends from a J-point depression to a change in slope of the ST-segment upward toward the electrocardiogram baseline.

4. A system as in claim 2 wherein said means for representing the baseline draw said isoelectric baseline at the horizontal level defined by the point where the slope of an immediately preceding PR interval changes.

5. A system as in claim 4 wherein said end point of said ST-segment is defined as the point removed from the beginning of the ST-segment where the electrocardiogram changes slope.

6. A system as in claim 5 wherein said end point of said ST-segment is defined as the point removed from the beginning of the ST-segment where the electrocardiogram changes slope, thereby excluding the T-portion of the response.

7. A system as in claim 2 wherein said means for transforming signals representing ST-segment morphology comprise means for drawing orthogonal lines from beginning and end points of said ST-segment to an isoelectric baseline of said electrocardiogram to define an ST region, means for drawing an effective baseline from said beginning point of said ST-segment to the junction of the orthogonal from the end point and the isoelectric baseline thereby effectively dividing said ST region into two regions, and means coupled to said comparison means for forming a ratio between said two regions to compare to said threshold.

8. A system as in claim 7 wherein the end point of said ST-segment is defined as the point removed from the beginning of the ST-segment where the electrocardiogram changes slope.

9. A system as in claim 2 wherein the value calculating means automatically insert the value 80 mm or two seconds.

10. A system as in claim 2 wherein the value calculating means define a signal representing the critical threshold value is a function of horizontal displacement of the ST-segment.

11. A system as in claim 2 wherein said threshold value is calculated in said value calculating means as equal to 2/ts, where ts is the horizontal displacement of the ST-segment along the isoelectric baseline of the electrocardiogram.

12. A patient classification system as in claim 2 wherein said digitizing means include means for digitally representing an isoelectric baseline for said ECG, said means for representing horizontal signam morphology using an effective horizontal value comprising 2/ts.