Device for biostimulation of tissue and method for treatment of tissue

• US 4,930,504 A
• Filed: 11/13/1987
• Issued: 06/05/1990
• Est. Priority Date: 11/13/1987
• Status: Expired due to Fees

• Current Assignee: Omega Universal Limited
• Original Assignee: Omega Universal Holdings Limited
• Inventors: Diamantopoulos, Costas A., Alexandrou, Alex P.
• Primary Examiner(s): Coven, Edward M.
• Assistant Examiner(s): HARRISON, JESSICA
• Application Number:
  US07/120,565
• Time in Patent Office: 935 Days
• Field of Search: 128/395, 128/396, 128/397, 128/303.1, 128/362, 250/494.1, 250/495.1, 250/504 H
• US Class Current: 607/88
• CPC Class Codes: A61B 2018/2065 Multiwave; Wavelength mixing, e.g. using four or more wavelengths pilot laser A61B2018/2025
• CPC Class Codes: A61B 2090/065 for measuring contact or contact pressure
• CPC Class Codes: A61N 2005/0633 Arrangements for lifting or hinging the frame which supports the light sources
• CPC Class Codes: A61N 2005/0644 Handheld applicators
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 2005/0662 Visible light
• CPC Class Codes: A61N 5/0616 Skin treatment other than tanning
• CPC Class Codes: A61N 5/067 using laser light

Abstract

A device for biostimulation of tissue is disclosed comprising an array of substantially monochromatic radiation sources of a plurality of wavelengths, preferably of at least three different wavelengths. The radiation sources are arranged within the array such that radiation of at least two different wavelengths passes directly or indirectly through a single point located within the treated tissue. The radiation sources are preferably laser diodes, superluminous diodes or similar light-emitting diodes that, while low-power radiation sources, can provide significant energy densities to a treatment area. A method of treatment of tissue comprising exposing the treated tissue to the above-described device is also disclosed. The device for biostimulation of tissue may be included within a system with a control panel, a power source, variable pulse frequency, variable pulse duration, a timer for timing the period of treatment, a device for measuring the conductivity of the treated tissue, a device for measuring the optical power emitted by the radiation sources and/or a device for detecting emissions from the radiation sources.

Claims

1. A device for biostimulation of tissue comprising:

an array of substantially monochromatic radiation sources, said array comprising;

at least one such radiation source providing a first wavelength less than 830 nm;

at least one such radiation source providing a second wavelength greater than or equal to 830 nm and less than 900 nm; and

at least one such radiation source providing a third wavelength greater than or equal to 900 nm;

said radiation sources being arranged such that at least two radiation wavelengths among said first, second and third wavelengths simultaneously pass directly or indirectly through a single point located within said tissue.

2. The device for biostimulation of tissue of claim 1 wherein said radiation sources are selected from the group consisting of superluminous diodes and laser diodes.

3. The device for biostimulation of tissue of claim 2 wherein:

said first wavelength is selected from the group consisting of 650 nm, 660 nm, 680 nm, 750 nm, 780 nm, 800 nm, 810 nm and 820 nm;

said second wavelength is selected from the group consisting of 830 nm, 840 nm, 850 nm, 860 nm, 870 nm, and 880 nm; and

said third wavelength is selected from the group consisting of 900 nm, 904 nm, 950 nm, 1100 nm, 1300 nm and 1500 nm.

4. The device for biostimulation of tissue of claim 2 wherein said array comprises:

five 660 nm superluminous diodes;

one 820 nm laser diode;

ten 880 nm superluminous or laser diodes; and

five 950 nm superluminous diodes.

5. The device for biostimulation of tissue of claim 4 wherein:

said 820 nm diode is positioned in the center of said array;

said 880 nm diodes are evenly positioned about the circumference of a circle of 10.5 mm radius from the center of said array; and

said 660 nm diodes and 950 nm diodes are alternately positioned and evenly spaced about the circumference of a circle of 17 mm radius from the center of said array such that a radial line from the center of said array to each of said 660 nm of 950 nm diodes bisects the arc between two of said 880 nm diodes.

6. The device for biostimulation of tissue of claim 4 wherein:

said 820 nm diode is positioned in the center of said array;

fives of said 880 nm diodes are evenly positioned about the circumference of a circle of 10.5 mm radius from the center of said array;

said 660 nm diodes are evenly positioned about the circumference of a circle of 17 mm radius from the center of said array such that a radial line from the center of said array to each of said 660 nm diodes bisects the arc between two of said 880 nm diodes in said first set;

said 950 nm diodes are evenly positioned about the circumference of a circle of 17 mm radius from the center of said array such that a radial line from the center of said array to each of said 950 nm diodes passes through the center of one of said 880 nm diodes in said first set; and

the remaining five of said 880 nm diodes are evenly positioned about the circumference of a circle of 27 mm radius from the center of said array such that a radial line from the center of said array to each of said 880 nm diodes passes through the center of one of said 660 nm diodes.

7. The device for biostimulation of tissue of claim 2 wherein said array comprises:

ten 660 nm superluminous diodes;

one 820 nm laser diode;

ten 880 nm superluminous or laser diodes; and

ten 950 nm superluminous diodes.

8. The device for biostimulation of tissue of claim 7 wherein:

said 820 nm diode is positioned in the center of said array;

said 880 nm diodes are evenly positioned about the circumference of a circle of 9.5 mm radius from the center of said array;

said 660 nm diodes are evenly positioned about the circumference of a circle of 18 mm radius from the center of said array such that a radial line from the center of said array to each of said 660 nm diodes bisects the arc between two of said 880 nm diodes; and

said 950 nm diodes are evenly positioned about the circumference of a circle of 27 mm radius from the center of said array such that a radial line from the center of said array to each of said 950 nm diodes passes through the center of one of said 880 nm diodes.

9. The device for biostimulation of tissue of claim 1 wherein:

said first wavelength is selected from the group consisting of 660 nm and 820 nm;

said second wavelength is selected from the group consisting of 875 nm and 880 nm; and

said third wavelength is 950 nm.

10. The device for biostimulation of tissue of claim 9 wherein said radiation sources are modulated at pulse frequencies selected from within the range of 2.28 Hz to 400 kHz.

11. The device for biostimulation of tissue of claim 10 wherein said pulse frequencies are selected from the group consisting of 2.28 Hz, 4.56 Hz, 9.12 Hz, 16 Hz, 18.24 Hz, 36.48 Hz, 73 Hz, 146 Hz, 292 Hz, 700 Hz, 1000 Hz, 5 kHz and 300 kHz.

12. A device for biostimulation of tissue comprising:

an array of substantially monochromatic radiation sources, said array comprising;

at least one such radiation source providing a first wavelength less than 830 nm;

at least one such radiation source providing a second wavelength greater than or equal to 830 nm and less than 875 nm;

at least one such radiation source providing a third wavelength greater than or equal to 875 nm and less than 900 nm; and

at least one such radiation source providing a fourth wavelength greater than or equal to 900 nm;

said radiation sources being arranged such that at least two radiation wavelengths among said first, second, third and fourth wavelengths simultaneously pass directly or indirectly through a single point located within said tissue.

13. The device for biostimulation of tissue of claim 12 wherein said radiation sources are selected from the group consisting of superluminous diodes and laser diodes.

14. The device for biostimulation of tissue of claim 13 wherein:

said first wavelength is selected from the group consisting of 650 nm, 660 nm, 680 nm, 750 nm, 780 nm, 800 nm, 810 nm and 820 nm;

said second wavelength is selected from the group consisting of 830 nm, 840 nm, 850 nm, 860 nm and 870 nm;

said third wavelength is 880 nm; and

said fourth wavelength is selected from the group consisting of 900 nm, 904 nm, 950 nm, 1100 nm, 1300 nm and 1500 nm.

15. A device for biostimulation of tissue comprising:

an array of substantially monochromatic light-emitting diodes, said array comprising;

at least one diode providing a first wavelength less than 800 nm; and

at least one diode providing a second wavelength greater than or equal to 800 nm;

said diodes being arranged such that radiation of said first and second wavelengths simultaneously passes directly or indirectly through a single point located within said tissue.

16. The device for biostimulation of tissue of claim 15 wherein:

said first wavelength is selected from the group consisting of 650 nm, 660 nm, 680 nm, 750 nm and 780 nm; and

said second wavelength is selected from the group consisting of 800 nm, 810 nm, 820 nm, 830 nm, 840 nm, 850 nm, 860 nm, 870 nm, 900 nm, 904 nm, 950 nm, 1100 nm, 1300 nm and 1500 nm.

17. A device for biostimulation of tissue comprising:

an array of substantially monochromatic low-power, light-emitting diodes, said diodes being modulated by frequency and pulse duration, individually having continuous power of 5 to 500 milliwatts, being arranged to emit light from essentially a single plane and together emitting an average power density at said plane of at least 10 mW/cm².

18. A device for biostimulation of tissue comprising:

an array of substantially monochromatic low-power, light-emitting diodes, said diodes being modulated by frequency and pulse duration, individually having continuous power of 5 to 500 milliwatts and being arranged so as to provide a power density of at least 120 mW/cm² at a point on the surface of said tissue.

19. A device for biostimulation of tissue comprising:

an array of substantially monochromatic non-gaseous continuous wave low-power radiation sources, said radiation sources being modulated by frequency and pulse duration, individually having continuous power of 5 to 500 milliwatts, being arranged to emit light from essentially a single plane and emitting an average power density at said plane of at least 10 mW/cm².

20. A device for biostimulation of tissue comprising:

an array of substantially monochromatic non-gaseous continuous wave low-power radiation sources, said radiation sources being modulated by frequency and pulse duration, individually having continuous power of 5 to 500 milliwatts and being arranged so as to provide a power density of at least 120 mW/cm² at a point on the surface of said tissue.

21. A method for treatment of tissue comprising:

providing an array of substantially monochromatic radiation sources, said array comprising;

at least one such radiation source providing a first wavelength less than 830 nm;

at least one such radiation source providing a second wavelength greater than or equal to 830 nm and less than 900 nm; and

at least one such radiation source providing a third wavelength greater than or equal to 900 nm;

said radiation sources being arranged such that when activated at least two radiation wavelengths among said first, second and third wavelengths simultaneously pass directly or indirectly through a single point located within said tissue; and

exposing said tissue to a radiation beam produced by said array.

22. The method for treatment of tissue of claim 21 further comprising selecting said radiation sources from the group consisting of superluminous diodes and laser diodes.

23. The method for treatment of tissue of claim 22 further comprising selecting the following radiation sources to form an array;

five 660 nm superluminous diodes;

one 820 nm laser diode;

ten 880 nm superluminous or laser diodes;

and five 950 nm superluminous diodes.

24. The method for treatment of tissue of claim 23 further comprising:

positioning said 820 nm diode in the center of said array;

positioning said 880 nm diodes evenly about the circumference of a circle of 10.5 mm radius from the center of said array; and

positioning said 660 nm diodes and 950 nm diodes alternately and evenly spaced about the circumference of a circle of 17 mm radius from the center of said array such that a radial line from the center of said array to each of said 660 nm or 950 nm diode bisects the arc between two of said 880 nm diodes.

25. The method for treatment of tissue of claim 23 further comprising:

positioning said 820 nm diode in the center of said array;

positioning five of said 880 nm diodes evenly about the circumference of a circle of 9.5 mm radius from the center of said array to form a first set;

positioning said 660 nm diodes evenly about the circumference of a circle of 18 mm radius from the center of said array such that a radial line from the center of said array to each of said 660 nm diodes bisects the arc between two of said 880 nm diodes in said first set;

positioning said 950 nm diodes evenly about the circumference of a circle of 27 mm radius from the center of said array such that a radial line from the center of said array to each of said 950 nm diodes passes through the center of one of said 880 nm diodes in said first set; and

positioning the remaining five of said 880 nm diodes evenly about the circumference of a circle of 27 mm radius from the center of said array such that a radial line from the center of said array to each of said remaining five 880 nm diodes passes through the center of one of said 660 nm diodes.

26. The method for treatment of tissue of claim 22 further comprising selecting the following radiation sources to form an array:

ten 660 nm superluminous diodes;

one 880 nm superluminous or laser diodes; and

ten 950 nm superluminous diodes.

27. The method for treatment of tissue of claim 26 further comprising:

positioning said 820 nm diode in the center of said array;

positioning said 880 nm diodes evenly about the circumference of a circle of 9.5 mm radius from the center of said array;

positioning said 660 nm diodes evenly about the circumference of a circle of 18 mm radius from the center of said array such that a radial line from the center of said array to each of said 660 nm diodes bisects the arc between two of said 880 nm diodes; and

positioning said 950 nm diodes evenly about the circumference of a circle of 27 mm radius from the center of said array such that a radial line from the center of said array to each of said 950 nm diodes passes through the center of one of said 880 nm diodes.

28. A method for treatment of tissue comprising:

removing from the surface of said tissue absorbing, refracting, reflecting or diffracting substances;

providing an array of substantially monochromatic radiation sources, said array comprising;

at least one such radiation source providing a first wavelength less than 830 nm;

at least one such radiation source providing a second wavelength greater than or equal to 830 nm and less than 900 nm; and

at least one such radiation source providing a third wavelength greater than or equal to 900 nm;

said radiation sources being arranged such that when activated at least two radiation wavelengths among said first, second and third wavelengths simultaneously pass directly or indirectly through a single point located within said tissue; and

exposing said tissue to a radiation beam produced by said array.

29. The method for treatment of tissue of claim 28 further comprising selecting said radiation sources from the group consisting of light-emitting diodes, superluminous diodes and laser diodes.

30. A method for treatment of tissue comprising:

exposing said tissue to a radiation source providing a first wavelength less than 830 nm;

simultaneously exposing said tissue to a radiation source providing a second wavelength greater than or equal to 830 nm and less than 900 nm;

simultaneously exposing said tissue to a radiation source providing a third wavelength greater than or equal to 900 nm; and

arranging said radiation sources such that at least two radiation wavelengths among said first, second and third wavelengths simultaneously pass directly or indirectly through a single point located within said tissue.

31. The method for treatment of tissue of claim 30 further comprising selecting said radiation sources from the group consisting of superluminous diodes and laser diodes.

32. A method for treatment of tissue comprising:

measuring the electrical conductivity of said tissue to locate an area of conductivity greater than a preselected threshold minimum conductivity, and

providing an array of substantially monochromatic radiation sources, said array comprising;

at least one such radiation source providing a first wavelength less than 830 nm;

at least one such radiation source providing a second wavelength greater than or equal to 830 nm and less than 900 nm; and

at least one such radiation source providing a third wavelength greater than or equal to 900 nm;

arranging said radiation sources such that at least two radiation wavelengths among said first, second and third wavelengths simultaneously pass directly or indirectly through a single point located within said tissue; and

exposing said area of conductivity to a radiation beam produced by said array.

33. The method for treatment of tissue of claim 32 further comprising selecting said radiation sources from the group consisting of superluminous diodes and laser diodes.

34. A method for treatment of tissue comprising:

exposing said tissue to a first radiation beam of substantially monochromatic radiation of a wavelength within one wavelength range selected from the group consisting of the wavelength range 300-830 nm, the wavelength range 830-900 nm and the wavelength range 900-1500 nm;

thereafter exposing said tissue to a second radiation beam of substantially monochromatic radiation of a wavelength within one wavelength range not previously selected from said group; and

thereafter exposing said tissue to a third radiation beam of substantially monochromatic radiation of a wavelength within the remaining wavelength range not previously selected from said group.

35. The method for treatment of tissue of claim 34 further comprising selecting said radiation sources from the group consisting of superluminous diodes and laser diodes.

36. A system for biostimulation of tissue comprising:

a biostimulation device comprising;

an array of substantially monochromatic radiation sources, said array comprising;

at least one such radiation source providing a first wavelength less than 830 nm;

at least one such radiation source providing a second wavelength greater than or equal to 830 nm and less than 900 nm; and

at least one such radiation source providing a third wavelength greater than or equal to 900 nm;

said radiation sources being arranged such that at least two radiation wavelengths among said first, second and third wavelengths simultaneously pass directly or indirectly through a single point located within said tissue; and

means in communication with said array for providing power to said radiation sources such that each of said radiation sources emits radiation at its characteristic wavelength.

37. The system for biostimulation of tissue of claim 36 wherein said system further comprises:

means in communication with said power-providing means for modulating the output of said sources with pulses and varying the modulation pulse frequency of said radiation sources.

38. The system for biostimulation of tissue of claim 36 wherein said system further comprises:

means in communication with said power-providing means for varying the pulse duration of said radiation sources.

39. The system for biostimulation of tissue of claim 36 wherein said system further comprises:

means in communication with said power-providing means for timing the period that power is provided to said radiation sources.

40. The system for biostimulation of tissue of claim 36 wherein said system further comprises:

means in communication with said power-providing means for measuring the electrical conductivity of said tissue.

41. The system for biostimulation of tissue of claim 36 wherein said system further comprises:

means in communication with said array for measuring the optical power emitted by said radiation sources.

42. The system for biostimulation of tissue of claim 36 wherein said system further comprises:

means in communication with said control panel for detecting radiation from said radiation sources; and

indicator means connected to said detecting means for indicating that radiation is being emitted from said radiation sources.

43. A system for biostimulation of tissue comprising:

a biostimulation probe comprising;

an array of substantially monochromatic radiation sources, said array comprising;

at least one such radiation source providing a first wavelength less than 830 nm;

at least one such radiation source providing a second wavelength greater than or equal to 830 nm and less than 900 nm; and

at least one such radiation source providing a third wavelength greater than or equal to 900 nm;

said radiation sources being arranged such that at least two radiation wavelengths among said first, second and third wavelengths simultaneously pass directly or indirectly through a single point located within said tissue;

means in communication with said array for providing power to said radiation sources such that each of said radiation sources emits radiation at its characteristic wavelength;

means in communication with said power-providing means for modulating the pulse frequency of said radiation sources;

means in communication with said power-providing means for varying the pulse duration of said radiation sources;

means in communication with said power-providing means for timing the period that power is provided to said radiation sources;

means in communication with said array for measuring the electrical conductivity of said tissue;

means in communication with said power-providing means for measuring the optical power emitted by said radiation sources; and

means in communication with said control panel for detecting emissions from said radiation sources.