Sinus arrhythmia monitor

• US 4,930,518 A
• Filed: 09/26/1988
• Issued: 06/05/1990
• Est. Priority Date: 09/26/1988
• Status: Expired due to Fees

• Current Assignee: William J.M. Hrushesky
• Original Assignee: William J.M. Hrushesky
• Inventors: Hrushesky, William J. M.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US07/248,588
• Time in Patent Office: 617 Days
• Field of Search: 128/671, 128/670, 128/700, 128/702, 128/695, 128/696, 128/716, 128/725, 128/687, 128/28
• US Class Current: 600/484
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00

Abstract

An instrument for measuring physiological characteristics of a living organism based upon the monitoring of the respiratory sinus arrhythmia senses a subject'"'"'s heartbeat and senses beginning of inspiration and expiration in the subject'"'"'s respiratory cycles. Instantaneous heart rate values are derived for each heartbeat. A time value is stored for each heartbeat, and from those time values the temporal location of each instantaneous heart rate within the respiratory cycle of the patient is determined. Based upon the time values and the instantaneous heart rate values corresponding to those time values, measurement values which indicate a characteristic of the subject'"'"'s cardiovascular and/or cardiopulmonary systems are derived. Corrections for the effects of mean heart rate, respiratory rate, respiratory volume and respiratory flow rate, and time of day of the test, are provided.

Claims

1. In an apparatus for measuring sinus arrhythmia of a subject, the improvement comprising:

means for determining respiratory volume;

means for determining respiratory rate;

means for determining mean heart rate;

means for correcting a measurement of sinus arrhythmia as a function of respiratory volume, respiratory rate and mean heart rate.

2. The improvement of claim 1 and further comprising:

means for determining average air flow rate during respiration; and

means for correcting the measurement of sinus arrhythmia as a function of average air flow rate.

3. In an apparatus for measuring sinus arrhythmia of a subject based upon sensing of heart beats and determination of instantaneous heart rates corresponding to those heart beats, the improvement comprising:

means for sensing beginnings of inhale and exhale components of breathing cycles of the subjects;

means for temporally locating the instantaneous heart rates within the inhale and exhale components of breathing cycles based upon temporal relationships between sensed heart beats and sensed beginnings of inhale and exhale components; and

means for deriving a measurement of sinus arrhythmia based upon the instantaneous heart rates and their corresponding temporal locations within the breathing cycles.

4. The invention of claim 3 wherein the means for temporally locating includes:

means for determining whether the instantaneous heart rate is located within an inhale or an exhale component of a sensed breathing cycle; and

means for locating the instantaneous heart rate as a percentage of time within that component.

5. The invention of claim 3 and further comprising:

means for determining a respiratory rate based upon the breathing cycles sensed; and

means for correcting the measurement of sinus arrhythmia for effects of respiratory rate.

6. The invention of claim 3 and further comprising:

means for determining a mean heart rate of the subject; and

means for correcting the measurement of sinus arrhythmia for effects of mean heart rate.

7. The invention of claim 3 and further comprising:

means for sensing respiratory volume; and

means for correcting the measurement of sinus arrhythmia for effects of respiratory volume.

8. The invention of claim 3 and further comprising:

means for determining rate of air flow during inspiration and expiration; and

means for correcting the measurement of sinus arrhythmia for effects of the rate of air flow.

9. The invention of claim 3 and further comprising;

means for determining a time of day when the measurement of sinus arrhythmia is performed; and

means for correcting the measurement of sinus arrhythmia for effects of the time of day.

10. A method of measuring physiologic characteristics of a subject, the method comprising:

sensing changes of direction of respiratory flow of the subject to produce inspiration and expiration signals;

sensing heart beats of the subject to produce heart beat signals;

determining an instantaneous heart rate for each heart beat;

determining temporal locations of the instantaneous heart rates within respiratory cycles based upon temporal relationships between the inspiration and expiration signals and the heart beat signals; and

deriving a measured physiological characteristic based upon the instantaneous heart rates and their corresponding temporal locations.

11. The method of claim 10 wherein deriving a measured characteristic includes:

deriving a curve which best fits the instantaneous heart rates and their corresponding temporal locations; and

deriving rhythm parameters from the curve.

12. The method of claim 11 wherein the rhythm parameters include a sinus arrhythmia amplitude.

13. The method of claim 11 wherein the rhythm parameters include a timing value representative of location at a peak of the curve which best fits.

14. The method of claim 10 and further comprising:

sensing respiratory volume; and

correcting the measured characteristics for effects of respiratory volume on sinus arrhythmia.

15. The method of claim 10 and further comprising:

determining a respiratory rate based upon the inspiration and expiration signals; and

correcting the measured characteristics for effects of respiratory rate on sinus arrhythmia.

16. The method of claim 10 and further comprising:

determining a mean heart rate based upon the heart beat signals; and

correcting the measured characteristic for effects of mean heart rate on sinus arrhythmia.

17. The method of claim 10 and further comprising:

sensing respiratory volume;

determining a respiratory rate based upon the inspiration and expiration signals;

determining a mean heart rate based upon the heart beat signals; and

correcting the measured characteristics as a function of respiratory volume, respiratory rate and mean heart rate.

18. The method of claim 10 and furher comprising:

sensing air flow rate during inspiration and expiration; and

correcting the measured characteristics for effects of air flow rate on sinus arrhythmia.

19. The method of claim 10 wherein determining temporal locations includes:

determining whether the instantaneous heart rate is located within an inhale or an exhale component of a respiratory cycle; and

locating the instantaneous heart rate within the component determined.

20. The method of claim 10 and further comprising:

determining time of day when sensing changes and sensing heart beats takes place; and

correcting the measured characteristic for effects of time of day on sinus arrhythmia.

21. The method of claim 10 and further comprising:

storing data representing a nomogram of test results from a plurality of subjects;

displaying the nomogram to permit comparision of the measured characteristic with the nomogram.

22. The method of claim 10 and further comprising:

providing an output presented as the test results from the subject as related to that expected for the subject'"'"'s age.

23. The method of claim 10 and further comprising:

storing test results of previous tests of the subject using the method; and

displaying the test results of the previous tests and the measured characteristics to permit a comparision.

24. In an apparatus for measuring sinus arrhythmia of a subject based upon sensing of heart beats and determination of instantaneous heart rates corresponding to those heart beats, the improvement comprising:

means for sensing breathing cycles of the subject;

means for determining whether the instantaneous heart rate is located within an inhale or an exhale component of a sensed breathing cycle; and

means for temporally locating the instantaneous heart rate as a percentage of time within that component; and

means for deriving a measurement of sinus arrhythmia based upon the instantaneous heart rates and their corresponding temporal locations within the breathing cycles.

25. In an apparatus for measuring sinus arrhythmia of a subject based upon sensing of heart beats and determination of instantaneous heart rates corresponding to those heart beats, the improvement comprising:

means for sensing breathin cycles of the subject;

means for temporally locating the instantaneous heart rates within the breathing cycles;

means for deriving a measurement of sinus arrhythmia based upon the instantaneous heart rates and their corresponding temporal locations within the breathing cycles;

means for determining a respiratory rate based upon the breathing cycles sensed; and

means for correcting the measurement of sinus arrhythmia for effects of respiratory rate.

26. In an apparatus for measuring sinus arrhythmia of a subject based upon sensing of heart beats and determination of instantaneous heart rates corresponding to those heart beats, the improvement comprising:

means for sensing breathing cycles of the subject;

means for temporally locating the instantaneous heart rates within the breathing cycles;

means for deriving a measurement of sinus arrhythmia based upon the instantaneous heart rates and their corresponding temporal locations within the breathing cycles;

means for sensing respiratory volume; and

means for correcting the measurement of sinus arrhythmia for effects of respiratory volume.

27. In an apparatus for measuring sinus arrhythmia of a subject based upon sensing of heart beats and determination of instantaneous heart rates corresponding to those heart beats, the improvement comprising:

means for sensing breathing cycles of the subject;

means for temporally locating the instantaneous heart rates within the breathing cycles;

means for deriving a measurement of sinus arrhythmia based upon the instantaneous heart rates and their corresponding temporal locations within the breathing cycles;

means for determining rate of air flow during inspiration and expiration; and

means for correcting the measurement of sinus arrhythmia for effects of the rate of air flow.

28. In an apparatus for measuring sinus arrhythmia of a subject based upon sensing of heart beats and determination of instantaneous heart rates corresponding to those heart beats, the improvement comprising:

means for sensing breathing cycles of the subject;

means for temporally locating the instantaneous heart rates within the breathing cycles;

means for deriving a measurement of sinus arrhythmia based upon the instantaneous heart rates and their corresponding temporal locations within the breathing cycles;

means for determining a time of day when the measurement of sinus arrhythmia is performed; and

means for correcting the measurement of sinus arrhythmia for effects of the time of day.

29. An apparatus for noninvasive quantitative measurement of physiologic characteristics of a living subject, the apparatus comprising:

means for providing first signals representative of sensed heart beats of the subject;

means for sensing breathing cycles of the subject and providing second signals representative of beginning of inhale and exhale components of the breathing cycles;

means responsive to the first signals for providing first digital data representative of instantaneous heart rate of each sensed heart beat;

means for determining a temporal location of each of the instantaneous heart rates within the breathing cycles based upon temporal relationships of the first and second signals and providing second digital data representative of the temporal location;

means for analyzing the first and second digital data to derive a digital value indicative of a physiological characteristic of the subject; and

means for providing a human perceivable output as a function of the derived digital value.

30. The apparatus of claim 29 wherein the means for analyzing includes:

means for deriving a mathematical function which best and most qualitatively portrays a relationship of the first and second digital data; and

means for deriving the digital value from the mathematical function.

31. The apparatus of claim 30 wherein the digital value is representative of sinus arrhythmia amplitude.

32. The apparatus of claim 30 wherein the mathematical function is a cosine curve and the digital value is representative of location of a peak of the cosine curve.

33. The apparatus of claim 29 and further comprising:

means for providing a third signal representative of respiratory volume;

means for providing a fourth signal representative of air flow rates during inspiration and expiration;

means for deriving a mean heart rate value from the first signal;

means for deriving a respiratory rate value from the second signals; and

means for correcting the digital value as a function of the respiratory volume, the mean heart rate, the respiratory rate and air flow rate.

34. The apparatus of claim 29 and further comprising:

means for providing a third signal representative of respiratory volume; and

means for correcting the digital value for effects of respiratory volume on sinus arrhythmia.

35. The apparatus of claim 29 and further comprising:

means for providing a signal representative of average air flow rate during inspiration and expiration; and

means for correcting the digital value for effects of average air flow rate on sinus arrhythmia.

36. The apparatus of claim 29 and further comprising:

means for providing a mean heart rate based upon the first signals; and

means for correcting the digital value for effects of mean heart rate on sinus arrhythmia.

37. The apparatus of claim 29 and further comprising:

means for providing a respiratory rate value as a function of the second signal; and

means for correcting the digital value for effects of respiratory rate on sinus arrhythmia.

38. The apparatus of claim 29 and further comprising:

means for providing a time of day value representative of a time of day when the measurement of physiologic characteristics was performed; and

means for correcting the digital value for effects of time of day on sinus arrhythmia.

39. The apparatus of claim 29 wherein the second signals include an inspiration signal representative of onset of inhalation and an expiration signal representative of onset of exhalation.

40. The apparatus of claim 39 wherein the means for determining temporal location includes:

means for determining temporal location of instantaneous heart rates for sensed heart beats within an inhale component of a breathing cycle as a function of time from an inspiration signal to the first signal corresponding to the sensed heart beats and time from the inspiration signal to a next expiration signal; and

means for determining temporal location of instantaneous heart rates for the sensed heart beats within an exhale component of a breathing cycle as a function of time from an expiration signal to the first signal corresponding to the sensed heart beats and time from the expiration signal to a next inspiration signal.

41. The apparatus of claim 29 and further comprising:

means for storing data representing a nomogram of test results from a plurality of test subjects; and

means for displaying the nomogram based upon the stored data to permit comparison of the digital value with digital values produced by testing other subjects.

42. The apparatus of claim 29 and further comprising:

means for reporting data based upon a relationship of the subject'"'"'s test result compared to that expected for the subject'"'"'s age.

43. The apparatus of claim 42 and further comprising:

means for storing data representing a nomogram of test results from a plurality of test subjects; and

means for displaying the nomogram based upon the stored data to permit comparison of the digital value with digital values produced by testing other subjects.