Constant pressure variable flow pump

• US 4,931,050 A
• Filed: 04/13/1988
• Issued: 06/05/1990
• Est. Priority Date: 04/13/1988
• Status: Expired due to Term

• Current Assignee: Flowonix Medical, Inc.
• Original Assignee: Shiley Infusaid Incorporated
• Inventors: Idriss, Samir F.
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Lewis, Ralph
• Application Number:
  US07/180,916
• Time in Patent Office: 783 Days
• Field of Search: 604/65, 604/93, 604/131, 604/132, 604/134, 604/135, 604/140, 604/141, 604/151, 604/175, 604/246, 604/247, 604/890.1, 604/891.1, 604/153, 604/249, 128/DIG. 12, 137/803, 138/46
• US Class Current: 604/891.1
• CPC Class Codes: A61M 2205/3507 with implanted devices, e.g. external control
• CPC Class Codes: A61M 5/141 with capillaries for restricting fluid flow
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/16813 by controlling the degree of opening of the flow line
• CPC Class Codes: A61M 5/16881 Regulating valves on-off valves, e.g. clamps A61M39/28
• CPC Class Codes: F16L 55/027 Throttle passages
• CPC Class Codes: G05D 7/0186 without moving parts
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

A variable flow constant pressure implantable pump employs an in-line needle restrictor having a variable insertion distance in a capillary. The degree of insertion determines the effective restriction within the capillary. The restrictor may be repositioned following implantation to vary the drug delivery rate by changing the effective restriction in the capillary. Various couplings may be used such that an auxiliary or bolus port delivers infusate directly into the outlet catheter so that medication from the main chamber does not pass through the auxiliary chamber. A combination of double lumen catheters and T-connectors are employed to provide parallel infusion paths.

Claims

1. An infusion system implantable in the living body comprising:

a constant pressure reservoir for releasing fluid, an outlet conduit connectable to said reservoir,

a flow restriction element inserted into said conduit, said flow restriction element having an axial insertion length (L) of penetration in said conduit and,

means to vary the axial insertion length (L) of said flow restriction element from a point distant from an implantation site following implantation of said system wherein flow rate characteristics of said outlet conduit are adjusted so that the delivery rate of fluid from said reservoir is altered.

2. The infusion system of claim 1, further comprising:

a delivery catheter, means to attach in fluid communication said outlet conduit to an end of said catheter, said flow restriction element having one end passing through said means to attach into said outlet conduit and having a second end external to said means to attach.

3. The infusion system of claim 2, wherein said means to vary the axial length of said flow restriction element is connected to said second end of said flow restriction element and said means to vary the axial length of said flow restriction element is placed in an adjustment conduit attached to said outlet conduit at one end and sealed on the other end by a penetrable septum.

4. The infusion system of claim 3, wherein said means to vary the axial insertion length of said flow restriction element comprises a flexible stylet, said stylet having one end coupled to said second end of said flow restriction element and having another end connected to a linearly movable element disposed external to an implantation site when said system is implanted in a living body.

5. The infusion system of claim 4, wherein said stylet passes through an insertion needle that penetrates, said septum into said adjustment conduit.

6. The infusion system of claim 3, wherein said adjustment conduit defines a fluid cylinder, said means to vary the axial insertion length comprises a sealed piston actuator coupled to said second end of said flow restriction element, and a syringe penetrable to an implantation site through said self-sealing septum, said syringe delivering or removing fluid from said fluid cylinder whereby in response to a pressure differential across said piston actuator said piston coupled to said flow restriction element moves until an equilibrium position is reached thereby varying the axial insertion length (L) of said flow restriction element in said outlet conduit.

7. The infusion system of claim 2, further comprising a housing for said reservoir, a seal mounted on said housing and rotatable, a lead screw coupled to said seal on one side for rotation therewith, a lead nut mounted on said lead screw, said second end of said flow restriction element coupled to said lead nut and, means external to said housing couplable to said seal to rotate said seal and thereby vary the axial insertion length of said flow restriction element by linear movement of said lead nut on said lead screw.

8. The infusion system of claim 1, wherein said outlet conduit comprises a rigid member connected at each end to a rigid coupling, said flow restriction element inserted into said conduit through one of said rigid couplings and seal means through which said flow restriction element passes in said coupling.

9. The infusion system of claim 1, further comprising an outlet catheter in fluid communication with said outlet conduit, an auxiliary infusion chamber separated from said constant pressure reservoir and having a penetrable self-sealing septum, said auxiliary infusion chamber coupled to said outlet catheter to provide a flow path to an infusion site without fluid from said constant pressure reservoir passing through said auxiliary infusion chamber.

10. The infusion system of claim 9, wherein said outlet catheter comprises a double lumen catheter having one flow path from said auxiliary chamber and a second flow path from said constant pressure reservoir.

11. The infusion system of claim 10, further comprising a second auxiliary chamber, a T-connector providing a fluid coupling to said second flow path without fluid from said constant pressure reservoir passing through said second auxiliary chamber.