Pressure-sensitive medical sealant

• US 4,931,282 A
• Filed: 11/25/1987
• Issued: 06/05/1990
• Est. Priority Date: 11/25/1987
• Status: Expired due to Term

• Current Assignee: 3M Company
• Original Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Inventors: Asmus, Robert A., Duan, Daniel C.
• Primary Examiner(s): Kight, III, John
• Assistant Examiner(s): AZPURU, CARLOS A
• Application Number:
  US07/125,377
• Time in Patent Office: 923 Days
• Field of Search: 424/78, 424/80, 424/220, 424/429, 424/443, 424/448, 428/220, 514/210, 514/227, 514/953
• US Class Current: 424/78.06
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 24/06 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043, A61L24/046 take precedence
• CPC Class Codes: C08L 39/04 Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
• CPC Class Codes: Y10S 526/931 Pressure sensitive adhesive

Abstract

A pressure-sensitive medical sealant composition comprising (a) a crosslinked, swellable polymeric matrix made from an N-vinyl lactam monomer and a multi-ethylenically unsaturated compound, wherein the ethylenic groups are vinyl groups, allyl groups or methallyl groups, which groups are bonded to nitrogen or oxygen atoms; (b) a plasticizer; and (c) an antimicrobial. The medical sealant is highly moisture vapor transmissive and is capable of incorporating large concentrations of iodine. The composition can be used in a variety of medical applications including as a teat plug, a wound or burn dressing, or as a sealant to seal junctions between medical instruments penetrating the skin and the skin. A method of preparing the medical sealant composition in a caulkable form is also disclosed.

Claims

1. A medical sealant composition comprising:

(a) a crosslinked, swellable polymeric matrix formed by a free-radical polymerization of at least one polymerizable monomeric species wherein at least 50 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams, and a crosslinker which is a multi-ethylenically unsaturated compound with the ethylenic groups being vinyl, allyl, or methallyl groups bonded to nitrogen or oxygen atoms, said N-vinyl lactam monomer being present in a concentration of about 5 to 99.9 percent by weight of the polymeric matrix precursor and said crosslinker being present in a concentration of about 0.02 to 5.0 percent by weight of said N-vinyl lactam monomer;

(b) a plasticizing solution present in a concentration of between about 55 and less than about 95 percent by weight of said medical sealant composition; and

(c) an antimicrobial present in a concentration of between about 0.01 and 10 percent by weight of said medical sealant composition;

which composition is formulated so as to have a T-Peel value of at least about 3 g/cm when measured on low density polyethylene, as described herein.

2. A composition in accordance with claim 1 wherein said multi-ethylenically unsaturated compound is selected from the group consisting of divinyl, diallyl and dimethallyl esters;

divinyl, diallyl and dimethallyl amides;

divinyl, diallyl and dimethallyl ethers; and

divinyl, diallyl and dimethallyl ureas.

3. A composition in accordance with claim 1 wherein said multi-ethylenically unsaturated compound is a divinyl amide or a divinyl urea in an amount of from about 0.02 to about 0.5 percent by weight of said monomeric species.

4. A composition in accordance with claim 1 wherein said multi-ethylenically unsaturated compound is a divinyl, diallyl or dimethallyl ester;

a diallyl or dimethallyl ether;

a diallyl or dimethallyl amide;

or a diallyl or dimethallyl urea in an amount of from about 0.05 to about 2 percent by weight of said monomeric species.

5. A composition in accordance with claim 1 wherein said multi-ethylenically unsaturated compound is a divinyl ether in an amount of from about 0.5 to about 5 percent by weight of said monomeric species.

6. A composition in accordance with claim 1 wherein the N-vinyl lactam monomer is N-vinyl-2-pyrrolidone.

7. A composition in accordance with claim 1 wherein said plasticizer is comprised of about 10 to 80 percent by weight glycerol in water.

8. A composition in accordance with claim 1 wherein said antimicrobial is selected from the group consisting of iodine, chlorhexidine gluconate, parachlorometaxylenol, zinc bacitracin, neomycin sulfate and polymyxin B sulfate.

9. A composition in accordance with claim 8 wherein said antimicrobial is iodine.

10. A composition in accordance with claim 1 wherein said polymeric matrix includes a polymerizable monomeric species selected from the group consisting of hydroxyalkyl acrylates and methacrylates;

water soluble amines;

water soluble hydrazine derivatives; and

mono-olefinic sulfonic acids and their salts.

15. A wound or burn dressing laminate comprising a layer of the composition of claim 1 and a layer of a moisture vapor permeable backing sheet suitable for use in a surgical dressing.

16. The wound or burn dressing of claim 15, wherein said N-vinyl lactam monomer is present in a concentration of about 5-45 percent by weight of said sealant composition.

17. A medical sealant composition in accordance with claim 1 wherein at least 90 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams.

18. A medical sealant composition in accordance with claim 1 wherein 100 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams.

11. A method of preparing a medical sealant composition, comprising the steps of

(a) preparing a mixture comprising at least one polymerizable monomeric species, and a crosslinker which is a multiethylenically unsaturated compound wherein the ethylenic groups are vinyl groups, allyl groups, or methallyl groups bonded to nitrogen or oxygen atoms, wherein at least 50 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams and said crosslinker is present in a concentration of about 0.02 to 5.0 percent by weight of said N-vinyl lactam monomer;

(b) exposing said composition to sufficient energy to result in the formation of a crosslinked swellable polymeric matrix;

(c) grinding said polymer into a powder having an average particle size of less than about 0.25 cm;

(d) adding said powder to a plasticizer solution having an antimicrobial therein, said plasticizing solution being present in a concentration of between about 55 and less than about 95 percent by weight of said medical sealant composition, said antimicrobial being present in a concentration of between about 0.01 and 10 percent by weight of said medical sealant composition and said powder, plasticizing solution and antimicrobial being present in a concentration sufficient to provide said medical sealant composition with a T-Peel value of at least about 3 g/cm when measured on low density polyethylene, as described herein.

13. A caulkable medical sealant prepared according to the method of claim 11 wherein the amount of said N-vinyl lactam monomer is about 5-45 percent by weight of said sealant composition.

12. A method of preparing a medical sealant composition, comprising the steps of

(a) preparing a mixture comprising at least one polymerizable monomeric species, and a crosslinker which is a multiethylenically unsaturated compound wherein the ethylenic groups are vinyl groups, allyl groups, or methallyl groups bonded to nitrogen or oxygen atoms, and an antimicrobial, wherein at least 50 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams and said crosslinker is present in a concentration of about 0.02 to 5.0 percent by weight of said N-vinyl lactam monomer, and said antimicrobial being present in a concentration sufficient to provide the resultant medical sealant composition with about 0.01 to 10 percent by weight antimicrobial;

(b) exposing said composition to sufficient energy to result in the formation of a crosslinked swellable polymeric matrix;

(c) grinding said polymer into a powder having an average particle size of less than about 0.25 cm;

(d) adding said powder to a plasticizer solution, said plasticizing solution being present in a concentration of between about 55 and less than about 95 percent by weight of said medical sealant composition, and said powder and plasticizing solution being present in a concentration sufficient to provide said medical sealant composition with a T-Peel value of at least about 3 g/cm when measured on low density polyethylene, as described herein.

14. A caulkable medical sealant prepared according to the method of claim 12 wherein the amount of said N-vinyl lactam monomer is about 5-45 percent by weight of said sealant composition.