Aqueous based pharmaceutical coating composition for dosage forms

• US 4,931,285 A
• Filed: 04/28/1988
• Issued: 06/05/1990
• Est. Priority Date: 04/28/1988
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Edgren, David E., Theeuwes, Felix
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Horne, Leon R.
• Application Number:
  US07/187,621
• Time in Patent Office: 768 Days
• Field of Search: 424/468, 424/473, 424/488, 424/469, 424/474, 424/486
• US Class Current: 424/473
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/2866 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61K 9/2886 having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer of the type active core-drug layer-inactive layer A61K9/209

Abstract

A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug. F

Claims

1. An osmotic device comprising:

(a) a wall comprising an annealed subcoat and an overcoat, annealed at about 35°

C. to 65°

C. for 10 to 72 hours, wherein,

(1) the subcoat comprises a member selected from the group consisting of a cellulose ether, a cellulose ester and a cellulose ester-ether;

a plasticizer; and

an emulsifier comprising a member selected from the group consisting of nonionic, anionic and cationic emulsifiers; and

(2) the overcoat comprises a member selected from the group consisting of hydroxypropylcellulose, hydroxypropyl methylcellulose, carboxymethylcellulose and methylcellulose; and

, optionally, plasticizers;

which wall surrounds;

(b) a compartment;

(c) a therapeutically effective amount of drug in the compartment; and

,

(d) at least one passageway in the wall connecting the exterior with the interior of the device for delivering the drug over time.

2. The osmotic device according to claim 1, wherein the subcoat is an inside coat next to the compartment and the overcoat is an outside coat away from the compartment.