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Platinum-polymer complexes and their use as antitumor agents

  • US 4,931,553 A
  • Filed: 05/11/1988
  • Issued: 06/05/1990
  • Est. Priority Date: 05/11/1988
  • Status: Expired due to Fees
First Claim
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1. A polymeric platinum-amine complex of the formula ##STR9## wherein each A independently represents a monodentate amine ligand or NH3 or A2 represents a single bidentate amine ligand;

  • n is a positive integer up to 500;

    P is a divalent ligand of a physiologically acceptable homopolymer or copolymer bearing at least 2×

    n pendant anionic groups, pairs of which form covalent linkages with the Pt(II)A2 or Pt(IV)A2 group; and

    X is an anionic ligand.

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