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Extracellular matrix induction method to produce pancreatic islet tissue

  • US 4,935,000 A
  • Filed: 04/27/1987
  • Issued: 06/19/1990
  • Est. Priority Date: 04/03/1986
  • Status: Expired due to Term
First Claim
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1. A method of treating diabetes in a post-natal diabetic mammalian host which comprises:

  • forming a recombinant, under conditions necessary for growth of mammalian cells, of fetal mesenchyme which is capable of inducing differentiation of fetal epithelial cells to form pancreatic islet tissue and (b) said diabetic'"'"'s substantially pure ductal epithelium to thereby induce the formation of pancreatic islet tissue, and transplanting the pancreatic islet tissue so formed into said diabetic host at a site which supplies the necessary ingredients for growth and maintenance of the tissue.

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