Extracellular matrix induction method to produce pancreatic islet tissue
First Claim
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1. A method of treating diabetes in a post-natal diabetic mammalian host which comprises:
- forming a recombinant, under conditions necessary for growth of mammalian cells, of fetal mesenchyme which is capable of inducing differentiation of fetal epithelial cells to form pancreatic islet tissue and (b) said diabetic'"'"'s substantially pure ductal epithelium to thereby induce the formation of pancreatic islet tissue, and transplanting the pancreatic islet tissue so formed into said diabetic host at a site which supplies the necessary ingredients for growth and maintenance of the tissue.
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Abstract
A method and composition of regenerating tissue. More specifically, a method for regenerating pancreatic islet tissue having the histological and insulin-containing properties of islets typically found in neonatal or adult animals is described. The regenerated islet tissue is produced by fetal mesenchyme acting upon an epithelium such that an inductive message causes the epithelium to differentiate into islet tissue.
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9 Claims
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1. A method of treating diabetes in a post-natal diabetic mammalian host which comprises:
- forming a recombinant, under conditions necessary for growth of mammalian cells, of fetal mesenchyme which is capable of inducing differentiation of fetal epithelial cells to form pancreatic islet tissue and (b) said diabetic'"'"'s substantially pure ductal epithelium to thereby induce the formation of pancreatic islet tissue, and transplanting the pancreatic islet tissue so formed into said diabetic host at a site which supplies the necessary ingredients for growth and maintenance of the tissue.
- View Dependent Claims (3)
- 2. The method which comprises implanting into a post-natal living subject an effective amount of fetal mesenchyme of a type and age to elicit a biological response in other fetal cells, adjacent cells of said living subject from which the biological response is to be elicited whereby said biological response is elicited in said cells wherein said biological response is the induction of cells to form desired tissues.
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9. A method of treating diabetes in a post-natal diabetic mammalian host which method comprises:
- implanting into a living subject, an effective amount of fetal mesenchyme of a type and age to elicit biological response in other fetal cells, adjacent ductal epithelial cells or said host whereby said biological response is elicited in said cells wherein such biological response is the formation of islet tissue.
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