Devices for sampling, drainage or infusion of liquids from or to the human or animal body

• US 4,935,010 A
• Filed: 11/09/1987
• Issued: 06/19/1990
• Est. Priority Date: 11/20/1986
• Status: Expired due to Fees

• Current Assignee: Pharmacia Biosystems Limited
• Original Assignee: Pharmacia Limited (Pfizer Inc.)
• Inventors: Parapia, Liakatali G., Cox, Jeffrey A.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Polutta, Mark O.
• Application Number:
  US07/118,606
• Time in Patent Office: 953 Days
• Field of Search: 604/167, 604/122, 604/126, 604/168, 604/900, 604/169, 604/905, 604/283
• US Class Current: 604/122
• CPC Class Codes: A61M 2039/266 where the valve comprises venting channels, e.g. to insure better connection, to help decreasing the fluid space upon disconnection, or to help the fluid space to remain the same during disconnection
• CPC Class Codes: A61M 39/02 Access sites
• CPC Class Codes: A61M 39/045 pre-slit to be pierced by blunt instrument
• CPC Class Codes: A61M 39/0693 including means for seal penetration
• CPC Class Codes: Y10S 604/905 Aseptic connectors or couplings, e.g. frangible, piercable

Abstract

A device for use in the sampling or infusion of liquids from or to the human or animal body having a first connecting means (8) for connection to a cannula, a second connecting means (13) for connection to a source or drain of liquid and valve means (4,9) operable to open or close a flow path therebetween, the arrangement being such that in a closed condition of the valve means each of the connecting means is connected to a respective chamber (6, 7), each chamber having a respective venting means (20, 21) allowing the escape of air therefrom while preventing the escape of liquid and such that in an open condition of the valve means a flow path is established from one connecting means to the other through at least one of the chambers. The device allows connection to be made without spillage and removes air from the liquid.

Claims

1. A device for use in the sampling or infusion of liquids from or to the human or animal body comprising:

a housing defining a bore extending longitudinally through the housing, the housing having at one end of the bore a first connecting means for connection to a cannula, and defining a passageway communicating with the bore,

the housing having at the other end of the bore a second connecting means for connection to a source or drain of liquid, and defining a ducted member communicating with the bore,

valve means dividing the bore into first and second chambers and operable to open or close communication between the cannula and the source or drain of liquid and arranged such that in an open condition of the valve means communication is established from one connecting means to the other such that in use the sampled or infused liquid flows through at least one of the chambers and in a closed condition of the valve means the first and second connecting means are connected to the first and second chambers respectively, and

the housing being further provided with first and second venting means allowing the escape of air from the first and second chambers respectively while preventing the escape of liquid therefrom.

2. A device as claimed in claim 1 including means for closing at least one of the venting means when the valve means is in the open condition.

3. A device as claimed in claim 1 wherein the flow path provided in an open condition of the valve means extends linearly through the device from the second connecting means to the first connecting means whereby an elongate member may extend through the chambers and the cannula.

4. A device as claimed in claim 1 wherein each of the venting means comprises a hydrophobic filter comprising an air permeable barrier of a hydrophobic material.

5. A device as claimed in claim 1 wherein the valve means comprises an elastomeric membrane which separates one chamber from the other and which is penetrable by a cooperating ducted member to provide an open condition of the valve means and which membrane is self sealing on withdrawal of the member to provide a closed condition of the valve means.

6. A device as claimed in claim 5 wherein the ducted member defines a duct connected at one end to the second connecting means, the other end of the duct communicating in the open condition of the valve means with a first of the chambers connected to the first connecting means and in the closed condition of the valve means communicating with a second of the chambers, and wherein the second chamber defines a ore within which a piston portion of the ducted member is axially slidable, the ducted member having a ducted precursive end portion of reduced diameter extending towards and in axial alignment with the puncture site of the membrane whereby the ducted member is axially moveable into and out of penetrating engagement with the membrane.

7. A device as claimed in claim 5 wherein the membrane is of silicone rubber.

8. A device as claimed in claim 5 wherein the first connecting means is connected to the first chamber to provide communication between the cannula and the first chamber, the second chamber comprising a ore within which the ducted member is axially slidable, one end of the ducted member being connected to the second connecting means,

the other end of the ducted member comprising a ducted progressive end portion of the reduced diameter extending towards and in axial alignment with a puncture site of the membrane, and

wherein the ducted member defines a duct extending through the second connecting means and the progressive portion to provide communication in the open condition of the valve means between the source or drain of liquid and the first chamber and to provide communication in the closed condition of the valve means between the source or drain of liquid and the second chamber.

9. A device as claimed in claim 5 comprising externally accessible handle means for urging the ducted member into and out of penetration with the membrane.

10. A device as claimed in claim 9 including locking means for selectively locking the ducted member in its membrane penetrating position.

12. A device as claimed in claim 8 wherein the membrane include a a preformed central puncture extending through the membrane and defining the puncture site at which the ducted member may penetrate in use.

13. A device as claimed in claim 8 wherein the precursive end portion is axially tapered towards the membrane to facilitate penetration thereof.

14. A device as claimed in claim 8 including a piston portion of the ducted member intermediate the second connecting means and the progressive end portion thereof, annual seal means being mounted on the piston portion and extending into circumferential sealing contact with the wall of the bore.

15. A device as claimed in claim 14 wherein the second venting means is provided in a port extending radially from the bore at a location such that the second venting means is isolated from the second chamber by the seal means and piston where the valve means is in the open position.

16. A device as claimed in claim 8 wherein the membrane is provided with a zone of weakness to assist penetration of the ducted member when first penetrated, which zone of weakness defines the puncture site at which the membrane is punctured in use.

17. A device as claimed in claim 16 wherein the zone of weakness comprises a cruciform cut extending through the membrane.

18. A device as claimed in claim 17 wherein the membrane is radially compressed to assist self sealing on withdrawal of the ducted member.

19. A device as claimed in claim 4 wherein the material is ultra high molecular weight polyethylene.

11. A device for use in the sampling or infusion of liquids from or to the human or animal body comprising;

a housing defining first and second chambers;

a ducted member including a first end portion defining a preselected internal diameter and a second, ducted precursive end portion of reduced internal diameter;

valve means comprising an elastomeric membrane which separates one camber from the other and which is penetrable by the ducted member to provide an open condition of the valve means and which membrane is self-sealing on withdrawal of the member to provide a closed condition of the valve means, the membrane being radially compressed to assist said self sealing;

the membrane being provided with a zone of weakness to assist penetration of the ducted member when first penetrated, the zone of weakness comprising a cruciform cut extending through the membrane with a preformed central puncture extending through the membrane and defining a puncture site at which the ducted member may penetrate in use;

a first connecting means for connection to a cannula, and connected to the first chamber to provide communication between the cannula and the first chamber;

a second connecting means for connection to a source or drain of liquid, the second chamber comprising a bore within which the ducted member is axially slidable and one end of the ducted member being connected to the second connecting means, the second end of the ducted member being axially tapered and extending towards a puncture site of the membrane so as to be in axial alignment therewith, and wherein the ducted member defines a duct extending through the second connecting means and the precursive portion to provide communication in the open condition of the valve means between the source or drain of liquid and the first chamber and to provide communication in the closed condition of the valve means between the source or drain of liquid and the second chamber, the valve means thereby being operable to open of close a flow passageway between the cannula and the source or drain of liquid and is arranged such that in the open condition of the valve means, the first chamber, and the ducted member cooperate to form a flow passageway from one connecting means to the other, and in the closed condition of the valve means the first and second connecting means are connected to the first and second chambers respectively;

the ducted member including a piston portion intermediate the second connecting means and the precursive end portion thereof, with annular seal means being mounted on the piston portion and extending into circumferential sealing contact with the wall of the bore; and

the device further comprising first and second venting means allowing the escape of air from the first and second chambers respectively while preventing the escape of liquid therefrom, the second venting means being provided in a port extending radially from the bore at a location such that the second venting means is isolated from the second chamber by the seal means and piston where the valve means is in the open position.

20. A device for use in the sampling or infusion of liquids from or to the human or animal body comprising:

a housing defining first and second chambers;

a ducted member including a first end portion defining a preselected internal diameter and a second, ducted precursive end portion of reduced internal diameter;

valve means comprising an elastomeric membrane which separates one chamber from the other and which is penetrable by the ducted member to provide an open condition of the valve means and which membrane is self-sealing on withdrawal of the member to provide a closed condition of the valve means;

a first connecting means for connection to a cannula, and connected to the first chamber to provide communication between the cannula and the first chamber;

a second connecting means for connection to a source or drain of liquid, the second chamber comprising a bore within which the ducted member is axially slidable and one end of the ducted member being connected to the second connecting means, the second end of the ducted member extending towards and in axial alignment with a puncture site of the membrane, and wherein the ducted member defines a duct extending through the second connecting means and the precursive portion to provide communication in the open condition of the valve means between the source or drain of liquid and the first chamber and to provide communication in the closed condition of the valve means between the source or drain of liquid and the second chamber, the valve means thereby being operable to open of close a flow passageway between the cannula and the source or drain of liquid and is arranged such that in the open condition of the valve means, at least one of the chambers and the ducted member cooperate to form a flow passageway from one connecting means to the other, and in the closed condition of the valve means, the first and second connecting means ar connected to the first and second chambers respectively; and

the device further comprising first and second venting means allowing the escape of air from the first and second chambers respectively while preventing the escape of liquid therefrom.