Capacitive chemical sensor using an ion exchange surface

• US 4,935,207 A
• Filed: 06/19/1989
• Issued: 06/19/1990
• Est. Priority Date: 04/01/1986
• Status: Expired due to Fees

• Current Assignee: Johns Hopkins University
• Original Assignee: Johns Hopkins University
• Inventors: Newman, Arnold L., Stanbro, William D.
• Primary Examiner(s): Marcus, Michael S.
• Application Number:
  US07/368,926
• Time in Patent Office: 365 Days
• Field of Search: 422/68, 422/69, 422/90, 422/98, 436/150, 436/806, 338/34, 338/35, 324/60 R, 324/60 C, 324/61 R, 435/817
• US Class Current: 422/68.1
• CPC Class Codes: G01N 27/227 Sensors changing capacitance upon adsorption or absorption of fluid components, e.g. electrolyte-insulator-semiconductor sensors, MOS capacitors G01N27/225 takes precedence
• CPC Class Codes: G01N 27/3276 being a hybridisation with immobilised receptors using a FET type sensor G01N27/4145; concerning the hybridisation C12Q1/68
• CPC Class Codes: Y10S 435/817 Enzyme or microbe electrode
• CPC Class Codes: Y10S 436/806 Electrical property or magnetic property

Abstract

A capacitive chemical sensor is disclosed that uses an ion exchange layer to detect analyte ions in a liquid medium. An exchange mechanism occurs on the surface of the ion exchange layer, wherein a portion of the counter-ions are removed from the surface in favor of analyte ions. The resulting movement of counter-ions from the surface of the ion exchange layer alters the dielectric constant of the liquid medium along the surface of the ion exchange layer. This change in dielectric constant produces a change in capacitance of the capacitive chemical sensor.

Claims

1. A device for sensing analyte ions in a liquid, said device comprising:

a capacitor having at least one pair of spaced apart electrode elements, said electrode elements adapted to create an electric field therebetween;

an electrically insulating layer coating said electrode elements;

a first layer of ion exchange molecules coating said electrically insulating layer;

a second layer of counter-ion molecules attached to molecules of said first layer said second layer adapted to be covered by a test liquid containing analyte ions of interest so that counter-ion molecules are displaced from said first layer by said analyte ions in said test liquid until a dynamic equilibrium is obtained, said counter-ion molecules sized to be larger than analyte ions and to have a different dielectric constant than said test liquid; and

,

a means, associated with said capacitor, responsive to the average dielectric properties in a volume adjacent to said insulating layer, wherein displacement of said counter-ion molecules from attachment to said first layer alters said average dielectric properties.

2. The device of claim 1, wherein each of said ion exchange molecules includes a cation exchange site and wherein each of said counter ion molecules carries a positively charged site.

3. The device of claim 1, wherein each of said ion exchange molecules includes an ion exchange site and wherein each of said counter-ion molecules a negatively charged site.

4. The device of claim 1, wherein each of said electrode elements comprises a plurality of spaced apart finger electrodes.

5. The device of claim 1, wherein said counter-ion molecules are selected from the group consisting of protein molecules and fatty acids.

6. The device of claim 1, wherein said counter-ion molecules are large compared to water molecules and have a lower dielectric constant than water molecules.

7. The device of claim 1, wherein said electrode elements are made from doped semiconductor material.

8. The device of claim 1, wherein said electrical elements are made from electrically conductive material.

9. The device of claim 1, further comprising an electronic means, operably coupled to second capacitor, for measuring and displaying a change in capacitance.

10. The device of claim 1, wherein said capacitor is positioned in a chamber, said chamber adapted to be at least partially filled with said test liquid.

11. The device of claim 10, wherein said chamber includes an opening exposed to said test liquid containing analyte ions.

12. The device of claim 11, wherein a membrane covers said opening, said membrane having pores sized to prevent escape of counter-ion molecules from said chamber.

13. A differential sensor for sensing analyte ions in a liquid, comprising:

a first capacitor having at least one pair of spaced apart electrode elements said first capacitor comprising,

a. an electrically insulating layer covering said electrode elements,

b. a first layer of ion exchange molecules coating said electrically insulting layer,

c. a second layer of counter-ion molecules attached to molecules of said first layer, said second layer adapted to be covered by a test liquid containing analyte ions of interest so that counter-ion molecules are displaced from said first layer by said analyte ions in said test liquid until a dynamic equilibrium is obtained;

a second capacitor having at least one pair of spaced apart electrode elements and a layer of electrically insulating material coating said spaced apart electrode elements of said second capacitor and adapted to be exposed to said test liquid; and

,

an electronic means, operably coupled to said first and second capacitor for calculating the analyte concentration of the test liquid wherein analyte ions in the test liquid will displace a portion of said counter-ions from the surface of said ion exchange layer thereby changing the capacitance of said first capacitor.

14. The device of claim 13, wherein said counter-ion molecules are selected from the group consisting of protein molecules and fatty acids.

15. The device of claim 13, wherein in said counter-ion molecules are large compared to water molecules and have a lower dielectric constant than water molecules.

16. The device of claim 13, wherein said counter-ion molecules are larger than the analyte ion.

17. The device of claim 13, wherein said electrode elements for said first and second capacitor are made from doped semiconductor material.

18. The device of claim 13, wherein said electrode elements for said first and second capacitor are made from electrically conducted material.

19. The device of claim 13, wherein each of said ion exchange molecules have a cation exchange side and wherein each of said counter-ion molecules carries a positively charged site.

20. The device of claim 13, wherein each of said ion exchange molecules have an ion exchange site and wherein each of said counter-ion molecules carries a negatively charged site.

21. The device of claim 13, wherein said first and second capacitors are positioned in a chamber.

22. The device of claim 21, wherein said chamber includes an opening exposed to said test liquid containing analyte ions.

23. The device of claim 22, wherein a membrane covers said opening, said membrane having pores sized to prevent counter ion molecules from escaping from said chamber.

24. A device for sensing analyte ions, said device comprising:

a first capacitor having at 1east one pair of spaced apart electrode elements, said electrode elements adapted to create an electric field therebetween;

an electrically insulating layer coating said electrode elements;

a first layer of ion exchange molecules coating said electrically insulating layer;

a counter-ion supplying liquid;

a chamber means, surrounding said capacitor, for maintaining said counter-ion supplying liquid in contact with said first layer;

a second layer formed from said counter-ions attached in dynamic equilibrium to molecules of said first layer and displaceable therefrom upon contact with analyte ions of interest, said counter-ion molecules sized to be larger than analyte ions and to have a different dielectric constant than said counter-ion supplying liquid; and

,

a first electric means, associated with said first capacitor, responsive to the average dielectric properties in a volume adjacent to said insulating layer, wherein displacement of said counter-ion molecules from attachment to said first layer alters said average dielectric properties.

25. The device of claim 24, wherein said chamber means includes a means for introducing a liquid contain analyte into said chamber means.

26. The device of claim 25, further comprising:

a second capacitor having at least one pair of spaced apart electrode elements and a layer of electrically insulating material coating said spaced apart electrode elements of said second capacitor and adapted to be exposed to said liquid containing analyte; and

,

a second means, associated with said second capacitor, responsive to the average dielectric properties in a volume adjacent to said insulating layer.