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Minimum procedure system for the determination of analytes

  • US 4,935,346 A
  • Filed: 08/13/1986
  • Issued: 06/19/1990
  • Est. Priority Date: 08/13/1986
  • Status: Expired due to Term
First Claim
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1. In a method for determining glucose in a blood sample employing a membrane and a signal-producing system which reacts with glucose to produce a light-absorptive dye product, said system being bound to the membrane, and in which the amount of said dye product is determined by means of a reflectance measurement from a surface of said membrane, an improvement which comprises:

  • applying an unmeasured whole blood sample to a first surface of a single-layer, substantially reflective, porous, hydrophilic membrane having pores of a size sufficient to exclude red blood cells and which contains said signal-producing system;

    making said reflectance measurement on a second surface of said membrane other than the surface to which said sample is applied without removing excess sample or red blood cells from said first surface; and

    determining the concentration of glucose in said sample from said reflectance measurement.

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