Drug delivery apparatus including beneficial agent chamber with chimney for a directed flow path

• US 4,936,829 A
• Filed: 10/19/1988
• Issued: 06/26/1990
• Est. Priority Date: 10/19/1988
• Status: Expired due to Term

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Younkes, William E., Zdeb, Brian D., Roeser, Thomas J.
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Lewis, Ralph
• Application Number:
  US07/262,210
• Time in Patent Office: 615 Days
• Field of Search: 604/82-92, 604/413, 604/416, 604/406, 604/56, 604/410-412, 604/414, 604/415, 222/83, 222/211, 222/479, 222/564
• US Class Current: 604/85
• CPC Class Codes: A61M 5/1409 in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems needle sets A61M5/162

Abstract

A cartridge for introducing a beneficial agent into a medical fluid conduit is disclosed. The cartridge includes a pierceable stopper having a hollow, open ended protrusion extending into the cartridge chamber and having the beneficial agent retained therein by a liquid pervious barrier. The hollow, open ended protrusion creates a directed flow path within the cartridge.

Claims

1. A cartridge for introducing a beneficial agent into a fluid conduit comprising:

(a) a wall defining chamber for containing a beneficial agent; and

(b) pierceable closure means closing said chamber, said pierceable closure means including an outer face and an opposed inner face facing the defined chamber, said closure means further including a hollow, open ended protrusion extending from said inner face in a direction substantially parallel to the length of said cartridge, wherein said beneficial agent is disposed within said hollow protrusion and wherein said beneficial agent is retained within said hollow protrusion by means of a liquid pervious barrier.

2. The cartridge in accordance with claim 1, wherein said pierceable closure means comprises a pierceable stopper mounted within a mount of said defined chamber.

3. The cartridge in accordance with claim 1, wherein said liquid pervious barrier comprises a particular matter barrier.

4. The cartridge in accordance with claim 3, wherein said particulate matter barrier has a nominal pore size no larger than about 20 microns.

5. The cartridge in accordance with claim 3, wherein said particulate matter barrier has a nominal pore size of no greater than about 10 microns.

6. The cartridge as in claim 1, wherein said closure means is adapted to be pierced both at a point in alignment with the interior of said hollow protrusion and at a point in alignment with the area of said inner face external to said hollow protrusion.

7. The cartridge in accordance with claim 6, further comprising a flow connector adapted for mounting to the chamber, said flow connector including

(a) a base and

(b) two hollow cannulas, each pointed at each end, mounted within the base and extending in a direction substantially parallel to said hollow protrusion, said hollow cannulas being adapted to pierce the pierceable closure means, such that said first cannula pierces said closure means in alignment with said hollow protrusion and such that said second cannula pierces said closure means at a point on said closure means inner face external to said hollow protrusion.

8. The cartridge as in claim 7, said base including a chamber distant side, wherein said second cannula extends from said chamber distant side of said base further than said first cannula.

9. The cartridge as in claim 7, further comprising a chamber facing side of said base, said second cannula extending from said chamber facing side of said base farther than said first cannula.

10. The cartridge as in claim 7, further comprising a chamber facing side of said base, said first and second cannulas extending substantially the same distance from said chamber facing side.

11. The cartridge as in claim 7, said base including a chamber distant side, further comprising a cap sealingly mounted over said portions of said cannulas extending from said chamber distant side of said base.

12. The cartridge as in claim 7, further comprising one of a key and a keyway disposed on said outer face of said closure means and the other of said key and keyway mounted upon said base, wherein said base is rotatable relative to said pierceable closure means and wherein said first cannula is in alignment with said hollow protrusion when said key and said keyway are engaged.

13. The cartridge as in claim 12, further comprising receptacle keyway means extending from said chamber opposite side of said base, for proper engagement with a receptacle mounted in the fluid conduit of an administration set.