Water insoluble derivatives of hyaluronic acid
First Claim
1. A method for making a water insoluble biocompatible gel, said method comprisingproviding an aqueous mixture comprising HA at a concentration in the range between 0.4% and 2.6% w/w,activating said HA with an activating agent to form activated HA, andreacting said activated HA with a nucleophile, under conditions producing said water insoluble biocompatible gel.
2 Assignments
0 Petitions
Accused Products
Abstract
A method for making a water insouble bicompatible gel includes activating HA with an activating agent to form activated HA, and reacting the activated HA with a nucleophile, under conditions producing the water insoluble bicompatible gel. Also, a method for making a water insoluble biocompatible film includes providing a biocompatible gel made according to the above method, and drying the gel or compressing the gel under conditions permitting escape of water from the gel. Also, a water insoluble composition including HA is prepared without the use of any bifunctional or polyfunctional nucleophile.
-
Citations
42 Claims
-
1. A method for making a water insoluble biocompatible gel, said method comprising
providing an aqueous mixture comprising HA at a concentration in the range between 0.4% and 2.6% w/w, activating said HA with an activating agent to form activated HA, and reacting said activated HA with a nucleophile, under conditions producing said water insoluble biocompatible gel.
- 30. A water insoluble composition comprising HA, said composition being substantially free of crosslinking.
-
39. A water insoluble composition comprising the reaction product of HA, an activating agent, and a nucleophile.
Specification