Elastomeric bladders for medical infusers
First Claim
1. An elastomeric bladder that is for use in a medical infuser and has improved resistance to rupture when inflated, the bladder being a tubular body:
- (a) made from a vulcanized homogeneous mixture of synthetic polyisoprene having about 90% to about 98% cis-1,4 linkages and a material selected from the group consisting of particulate silicon dioxide and particulate carbon black having a nominal average diameter in the range of about 1×
10-5 to about 5×
10-3 mm;
(b) into which a nontoxic, substantially nonleachable antioxidant has been diffused after vulcanization; and
(c) the amounts of silicon dioxide, carbon black and antioxidant being sufficient to make the inflated half-life of a population of the bladders at 40°
C. at least about ten times longer than the half-life of a comparable population of bladders made from said vulcanized synthetic polyisoprene but without the silicon dioxide, carbon black and the antioxidant.
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Accused Products
Abstract
Elastomeric bladders having improved resistance to spontaneous rupture when inflated are made by vulcanizing a homogeneous mixture of synthetic polyisoprene having 90% to 98% cis-1,4 linkages, 3 to 10 phr fumed silicon dioxide, and vulcanizing agent while simultaneously forming the mixture into hollow cylindrical bodies. After being formed the bodies are solvent extracted to remove unreacted vulcanizing agent and the degradation products of the vulcanizing agent. Following the solvent extraction about 0.2 to 2 phr of a nontoxic, nonleachable antioxidant are imbibed into the bodies by contacting the bodies with a liquid solution of the antioxidant.
11 Citations
47 Claims
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1. An elastomeric bladder that is for use in a medical infuser and has improved resistance to rupture when inflated, the bladder being a tubular body:
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(a) made from a vulcanized homogeneous mixture of synthetic polyisoprene having about 90% to about 98% cis-1,4 linkages and a material selected from the group consisting of particulate silicon dioxide and particulate carbon black having a nominal average diameter in the range of about 1×
10-5 to about 5×
10-3 mm;(b) into which a nontoxic, substantially nonleachable antioxidant has been diffused after vulcanization; and (c) the amounts of silicon dioxide, carbon black and antioxidant being sufficient to make the inflated half-life of a population of the bladders at 40°
C. at least about ten times longer than the half-life of a comparable population of bladders made from said vulcanized synthetic polyisoprene but without the silicon dioxide, carbon black and the antioxidant. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 12)
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9. An elastomeric bladder that is for use in a medical infuser and has improved resistance to rupture when inflated, the bladder being a tubular body:
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(a) made from a vulcanized homogeneous mixture of synthetic polyisoprene having about 90% to about 98% cis-1,4 linkages and from about 3 to about 10 phr of a material selected from the group consisting of particulate silicon dioxide and particulate carbon black having a nominal average diameter in the range of about 1×
10-5 to about 5×
10-3 mm;(b) into which from about 0.2 to about 2 phr of a nontoxic, substantially nonleachable antioxidant has been diffused after vulcanization; and (c) the inflated half-life of a population of said bladders at 40°
C. being at least about ten times longer than the half-life of a comparable population of bladders made from said vulcanized synthetic polyisoprene but without the silicon dioxide, carbon black and antioxidant. - View Dependent Claims (10, 11, 13, 14, 15)
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17. An elastomeric bladder that is for use in a medical infuser, the bladder being a tubular body:
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(a) made from a homogeneous vulcanized mixture of polyisoprene having about 90% to 98% cis-1,4 linkages and about 3 to about 10 phr fumed silicon dioxide; and (b) into which about 0.2 to about 2 phr of a nontoxic, substantially nonleachable antioxidant has been diffused after vulcanization; whereby said bladder will have an improved resistance to rupture when inflated at 40°
C., as compared to bladders formed from said polyisoprene without said silicon dioxide and said antioxidant. - View Dependent Claims (18, 19, 20, 21, 22, 27, 28, 39, 40)
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23. An elastomeric bladder that is for use in a medical infuser and has improved resistance to spontaneous rupture when inflated at 40°
- C., the bladder being a tubular body;
(a) made from a homogeneous mixture of synthetic polyisoprene having about 96% to about 98% cis-1,4 linkages and about 5 phr fumed silicon dioxide having a surface area of 200±
20 m2 /gram, the mixture being vulcanized with about 1.5 phr dicumyl peroxide; and(b) into which about 1 phr of 1,3,5-trimethyl-2,4,6-tris (3,5-di-t-butyl-4-hydroxybenzyl) benzene has been diffused after vulcanization.
- C., the bladder being a tubular body;
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24. A process for making an elastomeric bladder for use in a medical infuser and having improved resistance to rupture when inflated comprising:
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(a) mixing homogeneously a synthetic polyisoprene having a molecular structure with about 90% to about 98% cis-1,4 linkages, a material selected from the group consisting of particulate silicon dioxide and particulate carbon black having a nominal average diameter in the range of about 1×
10-5 to about 5×
10-3 mm and an amount of vulcanizing agent sufficient to vulcanize the mixture;(b) subjecting the mixture to vulcanizing conditions while simultaneously forming the mixture into a tubular body; (c) solvent extracting unreacted vulcanizing agent and the degradation products of the vulcanizing agent from the body; and (d) diffusing an amount of a nontoxic, substantially nonleachable antioxidant into the body by contacting the body with a liquid solution of the antioxidant; the amount of particulate material together with the amount of antioxidant diffused into the body after vulcanization being sufficient to make the inflated half-life at 40°
C. of a population of bladders so formed at least about ten times longer than a comparable population of bladders without the particulate material and the antioxidant. - View Dependent Claims (25, 26, 29, 30, 36, 37, 38, 41, 42)
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31. A process for making an elastomeric bladder having an improved resistance to rupture when inflated, said process comprising the steps of:
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(a) mixing homogeneously (i) a synthetic polyisoprene having a molecular structure with about 90% to about 98% cis-1,4 linkages, (ii) an amount of dicumyl peroxide sufficient to vulcanize the mixture, and (iii) from about 3 to about 10 phr of particulate silicon dioxide having a nominal average diameter in the range of about 1×
10-5 to about 5×
10-3 mm;(b) subjecting the mixture to vulcanizing conditions while simultaneously forming the mixture into a tubular body; (c) solvent extracting unreacted vulcanizing agent and the degradation products of the vulcanizing agent from the body with ethyl acetate; (d) diffusing from about 0.2 to about 2 phr of a nontoxic, substantially nonleachable hindered polyphenol antioxidant into the body by contacting the vulcanized body with an ethyl acetate solution of the antioxidant; whereby the inflated half-life at 40°
C. of a population of bladders so formed is at least ten times greater than a comparable population of bladders formed without the silicon dioxide and antioxidant. - View Dependent Claims (16, 32, 33, 34, 35, 43, 44, 45, 46, 47)
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Specification