Process for the preparation of a hydroxyl apatite material

• US 4,938,938 A
• Filed: 11/22/1988
• Issued: 07/03/1990
• Est. Priority Date: 03/26/1987
• Status: Expired due to Term

• Current Assignee: PROF. DR.DR. ROLF EWERS, GRAF-SPEE-STR. 46, D-2300 KIEL 1
• Original Assignee: Rolf Ewers
• Inventors: Bremen, Ewers, Rolf, Simons, Bruno, Kasperk, Christian
• Primary Examiner(s): Doll, John
• Assistant Examiner(s): Lange, Wayne A.
• Application Number:
  US07/278,924
• Time in Patent Office: 588 Days
• Field of Search: 423/308, 423/311, 433/201.1, 623/16
• US Class Current: 423/308
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: C01B 25/16 Oxyacids of phosphorus; Salts thereof peroxyacids or salts thereof C01B15/00
• CPC Class Codes: C01B 25/325 Preparation by double decomposition
• CPC Class Codes: Y10S 623/92 Method or apparatus for preparing or treating prosthetic

Abstract

A process is disclosed for the preparation of a hydroxyl apatite material by means of hydrothermal conversion using as starting material a calcitic skeleton which has been purified of organic substances. The conversion is carried out under saturated steam pressure, preferably at a temperature in the range of from 100° C. to 250° C. The influence of the reaction, or rather the defect density of the materials is preferably achieved by the addition of fluoride ions. In addition, the adaption of the material to differing implantation areas as hard tissue replacements as well as the preparation of workable compact implants is described.

Claims

1. A process for the preparation of a carbonaceous hydroxyl apatite material by means of hydrothermal conversion, comprising the following steps:

(a) cleaning a hard tissue from organic substances,

(b) converting the tissue with an aqueous concentrated solution of (NH₄)₂ HPO₄ solution at a temperature up to 250°

C.,

(c) executing the conversion in an autoclave under saturation steam pressure, and

(d) during conversion compensating for the content of Mg²⁺ -ions by addition of F of ions.

2. A process according to claim 1, wherein the pH value of the aqueous solution is adjusted to a predetermined value.

3. A process according to claim 2, wherein the pH value is adjusted to at least 8.5.

4. A process according to claim 1, wherein the hydroxyl apatite material is subjected to an after treatment by tempering.

5. A process according to claim 1, wherein the hydroxyl apatite material is treated with a slurry of a binder material and the indicated process steps for the hydrothermal conversion are then repeated.

6. A process according to claim 5, wherein the binder material is slaked lime and the hydrothermal conversion is carried out after setting of the lime.

7. A process according to claim 5, wherein the hydroxyl apatite material is placed in a mold prior to treatment with the binder material.

8. A process according to claim 1, wherein the hydroxyl apatite material is treated with a slurry of binder material before conversion.

9. A process according to claim 1, wherein the hydroxyl apatite material is placed in a mold.

10. A process according to claim 1, wherein the starting material comprises skeletons of lime-encrusted algae.

11. A process according to claim 1, wherein the starting material comprises an organic, porous hard tissue.

12. A process according to claim 11, wherein the hard tissue is decarbonised prior to the conversion.