Aerosol composition for in vivo imaging

• US 4,938,947 A
• Filed: 01/04/1988
• Issued: 07/03/1990
• Est. Priority Date: 11/01/1985
• Status: Expired due to Fees

• Current Assignee: Centre National De La Recherche Scientifique
• Original Assignee: Centre National De La Recherche Scientifique
• Inventors: Barot-Ciorbaru, Rita, Nicolau, Yves-Claude, Le Pape, Alain
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Thomas, J. E.
• Application Number:
  US07/142,242
• Time in Patent Office: 911 Days
• Field of Search: 424/1.1, 424/9, 424/7.1, 424/92, 424/450
• US Class Current: 424/1.13
• CPC Class Codes: A61K 2123/00 Preparations for testing in vivo
• CPC Class Codes: A61K 51/1231 Aerosols or breath tests, e.g. administration of gasses, emanators
• CPC Class Codes: A61K 51/1234 Liposomes
• CPC Class Codes: A61K 9/127 Liposomes

Abstract

The present invention relates to an aerosol composition for in vivo imaging or ex vivo diagnosis of tumors, which composition contains one or more soluble fragments of bacterial wall or cell peptidoglycan or equivalent synthetic compounds which are labelled with a radioactive, paramagnetic or fluorescent element and encapsulated in liposomes and a substrate which can be used for administration by aerosol.

Claims

1. Aerosol composition for in vivo imaging or ex vivo diagnosis of tumors, which composition contains one or more soluble fragments of bacterial cell peptidoglycan of Nocardia derivatives (NSPD) which are labelled with a radioactive, paramagnetic or fluorescent element and encapsulated in liposomes and a substrate which can be used for administration by aerosol.

2. Composition as claimed in claim 1, wherein the NSPD is labelled with ^99m technetium or with another emitter detectable by scintigraphy or counting.

3. Composition as claimed in claim 1, wherein the NSPD is labelled with a paramagnetic probe.

4. Composition as claimed in claim 1, wherein the NSPD is labelled with a fluorescent probe.

5. Composition as claimed in claim 1, wherein the liposome consists of at least one lipid having substantial surfactant properties with respect to cell tissue and is thus readily emulsifiable in cell tissue.

6. Composition as claimed in claim 5, wherein the liposome is a phosphatidylcholine/phosphatidylserine/cholesterol liposome.

7. Composition as claimed in claim 6, wherein the mole ratio of the components of the liposome is 4:

1;

5.

8. Composition as claimed in claim 1, wherein the NSPD is in combination with one or more products possessing substantial surfactant properties with respect to cell tissue.