Method and composition for treating xerostomia

• US 4,938,963 A
• Filed: 11/22/1988
• Issued: 07/03/1990
• Est. Priority Date: 11/22/1988
• Status: Expired due to Term

• Current Assignee: Parnell Pharmaceuticals, Inc.
• Original Assignee: Parnell Pharmaceuticals, Inc.
• Inventors: Parnell, Francis W.
• Primary Examiner(s): Rollins, John W.
• Assistant Examiner(s): Catchpole, W.
• Application Number:
  US07/275,124
• Time in Patent Office: 588 Days
• Field of Search: 424/195.1, 424/48, 424/440, 424/464
• US Class Current: 424/440
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006

Abstract

Methods and compositions are provided for alleviating xerostomia. The compositions are formulated from Yerba Santa extract and sweetener, and may be in aqueous solution or in gum or lozenge form. The compositions may additionally contain a stimulator compound effective to stimulate salivary gland secretion, e.g., citric acid, ascorbic acid, or both. Preservatives, flavoring agents, coloring agents, emulsifiers, and the like may be included in the compositions as well. The Yerba Santa-based compositions of the invention are orally administered to an affected patient to alleviate the symptoms of dry mouth.

Claims

1. A method for treating xerostomia, comprising orally administering, to an affected individual, an amount of an eriodictyon fluid composition effective to alleviate the symptoms of dry mouth, the eriodictyon fluid composition comprising eriodictyon fluid extract and sweetener.

2. The method of claim 1, wherein the eriodictyon fluid composition is an aqueous solution of eriodictyon fluid extract and sweetener.

3. The method of claim 2, wherein the composition contains about 0.25 wt.% to 10 wt.% eriodictyon fluid extract.

4. The method of claim 3, wherein the composition contains about 0.5 wt.% to 5 wt.% eriodictyon fluid extract.

5. The method of claim 1, wherein the eriodictyon fluid composition additionally includes a stimulator compound effective to stimulate salivary gland secretion.

6. The method of claim 5, wherein the stimulator compound is selected from the group consisting of citric acid, ascorbic acid and mixtures thereof.

7. The method of claim 6, wherein the composition contains about 0.25 wt.% to about 5.0 wt.% citric acid and about 0.01 wt.% to about 1.0 wt.% ascorbic acid.

8. The method of claim 1, wherein the composition contains about 1.0 wt.% to 30 wt.% sweetener.

9. The method of claim 8, wherein the composition contains about 10 wt.% to 20 wt.% sweetener.

10. The method of claim 9, wherein the composition contains about 15 wt.% sweetener.

11. The method of claim 1, wherein the Yerba Santa composition is administered in the form of a lozenge.

12. The method of claim 11, wherein the lozenge contains about 0.25 wt.% to about 10 wt.% eriodictyon fluid extract and about 1 wt.% to about 30 wt.% sweetener.

13. The method of claim 1, wherein the eriodictyon fluid composition is administered in the form of a gum.

14. The method of claim 1, wherein the gum contains about 0.25 wt.% to 10 wt.% eriodictyon fluid extract and about 1 wt.% to 30 wt.% sweetener.

18. The method of claim 1, wherein the eriodictyon fluid composition is administered such that an individual receives about 0.25 to 1.0 g. eriodictyon fluid extract four to six times in a twenty-four hour period.

15. A method for treating xerostomia, comprising orally administering, to an affected individual, an amount of an eriodictyon fluid composition effective to alleviate the symptoms of dry mouth, the eriodictyon fluid composition comprising about 0.25 wt.% to 10 wt.% eriodictyon fluid extract, about 1.0 wt.% to 30 wt.% sweetener, and a stimulator compound effective to stimulate salivary gland secretion.

16. The method of claim 15, wherein the stimulator compound is selected from the group consisting of citric acid, ascorbic acid and mixtures thereof.

17. The method of claim 16, wherein the composition contains about 0.25 wt.% to about 5.0 wt.% citric acid and about 0.01 wt.% to about 1.0 wt.% ascorbic acid.

19. The method of claim 15, wherein the eriodictyon fluid composition is administered such that an individual receives about 0.25 to 1.0 g. eriodictyon fluid extract four to six times in a twenty-four hour period.