Article having a hemocompatible surface

• US 4,939,007 A
• Filed: 03/07/1988
• Issued: 07/03/1990
• Est. Priority Date: 03/07/1988
• Status: Expired due to Fees

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Solomon, Donald D., Hu, Can B., Wells, Stanley C.
• Primary Examiner(s): Buffalow, Edith
• Application Number:
  US07/164,948
• Time in Patent Office: 848 Days
• Field of Search: 428/423.3, 428/423.7, 428/424.2, 428/425.5, 428/364, 528/28, 523/112, 424/28
• US Class Current: 428/34.1
• CPC Class Codes: A61L 33/068 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L33/062 takes precedence
• CPC Class Codes: C08G 18/61 Polysiloxanes
• CPC Class Codes: C08L 83/10 Block- or graft-copolymers containing polysiloxane sequences obtained by polymerising a compound having a carbon-to-carbon double bond on to a polysiloxane C08L51/08, C08L53/00
• CPC Class Codes: Y10T 428/13 Hollow or container type article [e.g., tube, vase, etc.]
• CPC Class Codes: Y10T 428/2913 Rod, strand, filament or fiber
• CPC Class Codes: Y10T 428/31554 Next to second layer of polyamidoester
• CPC Class Codes: Y10T 428/31565 Next to polyester [polyethylene terephthalate, etc.]
• CPC Class Codes: Y10T 428/31573 Next to addition polymer of ethylenically unsaturated monomer
• CPC Class Codes: Y10T 428/31598 Next to silicon-containing [silicone, cement, etc.] layer

Abstract

An article has a blood-contacting hemocompatible surface layer of a urethane-siloxane copolymer on a thermoplastic polymeric base material. The copolymer has siloxane segments prepared from hydroxyalkyl terminated polysiloxane glycols. The article is prepared by coextrusion of the base material and the copolymer.

Claims

1. An article having a hemocompatible surface comprising a thermoplastic polymeric base material having thereon a layer of a copolymer comprising a polyurethane segment and a hydroxyalkyl-terminated siloxane segment said layer being from 5 to 50% by weight of said material.

2. The article of claim 1 wherein said base material is selected from the group consisting of polyurethane, polyolefin, polyester and polyurethaneurea.

3. The article of claim 2 wherein said polyurethane has a Shore hardness of about 50A to 75D.

4. The article of claim 1 which is in the form of a tubing.

5. The article of claim 1 which is in the form of a fiber.

6. The article of claim 1 which is in the form of a sheet.

7. The article of claim 1 which is in the form of a film.

8. An article having a hemocompatible surface comprising a thermoplastic polyurethane base material of Shore hardness about 40A to 75D having thereon a layer of a copolymer comprising a polyurethane segment and a hydroxyalkyl- terminated polydimethyl siloxane segment said layer being from 5 to 50% by weight of said material.

9. The article of claim 8 which is a catheter.