Dispenser comprising displaceable matrix with solid state properties
First Claim
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1. A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising:
- (a) a wall that surrounds and defines an internal lumen, the wall comprising at least in a part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent;
(b) first means comprising a member selected from a solid and semisolid pharmaceutically acceptable carrier in the lumen for administering a beneficial agent to the animal environment of use, said means substantially maintaining its physical and chemical integrity while in the lumen of the dispenser;
(c) a beneficial agent in the first means for administering a beneficial agent;
(d) second means adjacent to the first means for occupying an increasing amount of space in the lumen for urging the first means comprising the beneficial agent from the dispenser; and
(e) an opened mouth in the dispenser comprising a cross-sectional dimension substantially equal to the cross-sectional dimension of the lumen for displacing the first means substantially intact and unchanged and comprising the beneficial agent for administering the beneficial agent to the environment of use.
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Abstract
A dispenser is enclosed for delivering a beneficial agent to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first means in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.
124 Citations
15 Claims
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1. A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising:
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(a) a wall that surrounds and defines an internal lumen, the wall comprising at least in a part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent; (b) first means comprising a member selected from a solid and semisolid pharmaceutically acceptable carrier in the lumen for administering a beneficial agent to the animal environment of use, said means substantially maintaining its physical and chemical integrity while in the lumen of the dispenser; (c) a beneficial agent in the first means for administering a beneficial agent; (d) second means adjacent to the first means for occupying an increasing amount of space in the lumen for urging the first means comprising the beneficial agent from the dispenser; and (e) an opened mouth in the dispenser comprising a cross-sectional dimension substantially equal to the cross-sectional dimension of the lumen for displacing the first means substantially intact and unchanged and comprising the beneficial agent for administering the beneficial agent to the environment of use. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising:
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(a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent; (b) a carrier comprising a member selected from the group consisting of a pharmaceutically acceptable solid and semisolid carrier in the lumen for administering a beneficial agent to the animal environment of use, said carrier symmetrical with the axis of the lumen and substantially maintaining its physical and chemical integrity while in the lumen of the dispenser; (c) a beneficial agent in the carrier; (d) means adjacent to the carrier for occupying an increasing amount of space in the lumen for urging the carrier comprising the beneficial agent from the dispenser; (e) means in the lumen for maintaining the dispenser in the animal environment of use over time; and
,(f) an opening in the wall of the dispenser comprising a cross-sectional dimension substantially equal to the cross-sectional dimension of the lumen for urging the carrier substantially intact and unchanged and comprising the beneficial agent for administering the beneficial agent to the environment of use.
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14. A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising:
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(a) a hollow body member comprising an internal lumen and provided with an opening substantially equivalent to the cross-section of the lumen for establishing communication with the lumen; (b) a pharmaceutically acceptable carrier comprising a member selected from the group consisting of a solid and semisolid carrier in the lumen for administering a beneficial agent to the animal environment of use, said carrier substantially keeping its integrity in the lumen; (c) a beneficial agent in the carrier; (d) means adjacent to the carrier for occupying an increasing amount of space in the lumen for pushing the carrier comprising the beneficial agent from the dispenser; (e) a wall that surrounds the hollow body member comprising at least in part a semipermeable composition that is permeable to the passage of fluid and substantially impermeable to the passage of a beneficial agent and, (f) an opening in the wall communicating with the lumen, which opening comprises a cross-section dimension corresponding to the cross-section of the carrier in the lumen for pushing the carrier intact from the lumen for administering the beneficial agent.
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15. A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising:
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(a) a hollow body member having an internal lumen and provided with an opening substantially equivalent to the cross-section of the lumen for establishing communication with the lumen; (b) first means in the lumen for administering a beneficial agent to the animal environment of use, said means substantially keeping its integrity in the lumen and comprising a member selected from the group consisting of a solid and semisolid pharmaceutically acceptable carrier; (c) a beneficial agent in the first means; (d) second means adjacent to the first means for occupying an increasing volume in the lumen for displacing the first means from the dispenser; (e) third means in the lumen for maintaining the dispenser in the animal environment over time; (f) a wall that surrounds the hollow body member comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of the beneficial agent; and
,(g) an opening in the wall communicating with the lumen, said opening comprising a cross-section substantially equivalent to the cross-section of the lumen for displacing the first means comprising the beneficial agent substantially intact and unchanged from the lumen for administering the beneficial agent to the animal environment.
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Specification