Method for manufacturing a synthetic vascular prosthesis

• US 4,941,870 A
• Filed: 12/30/1988
• Issued: 07/17/1990
• Est. Priority Date: 11/10/1986
• Status: Expired due to Fees

• Current Assignee: JMS Company Limited
• Original Assignee: Research Development Corporation Of Japan (Japan Science And Technology Agency), Medical Supply Depot, Ube-Nitto Kasei Company Limited (UBE Corporation)
• Inventors: Okada, Masao, Sakai, Kazuhiko, Kimura, Haruo, Ikada, Yoshito
• Primary Examiner(s): Cannon, Alan W.
• Application Number:
  US07/292,554
• Time in Patent Office: 564 Days
• Field of Search: 623/1, 623/66, 600/36, 264/41, 264/49, 264/344, 264/561, 427/2
• US Class Current: 600/36
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 29/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C08L 51/08 grafted on to macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device

Abstract

A synthetic vascular prosthesis comprises a hollow tubular base member having a multitude of continuous pores and formed of an elastomer material, and a hydrogel layer formed on the inner surface of the base member. The hydrogel layer is partly embedded in the inner portion of the base member at the pores, thereby permitting anchoring adhesion between the hydrogel layer and the base member. A method for manufacturing the synthetic vascular prosthesis is also disclosed, in which the formation of pores in the base member is effected by two separate steps and the hydrogel layer is formed after formation of an inner porous portion of the base member.

Claims

1. A method for manufacturing a synthetic vascular prosthesis comprising the steps of:

dissolving an elastomer material in a solvent;

adding an inorganic salt to the solution and adjusting the viscosity of the solution;

subjecting the solution to extrusion into a hollow tube;

cutting said tube to a predetermined length to form a tubular base member;

removing the solvent from said base member and drying said base member;

removing the inorganic salt in the inner portion of said base member by dissolution with an acid to form a porous inner portion of said base member;

coating a hydrogel material inside of said base member so that said hydrogel material, forms a hydrogel layer on said base member with partial infiltrating into the pores of said porous inner portion; and

further removing the inorganic salt in the outer portion of said base member by dissolution with an acid, thereby forming a porous outer portion having a multitude of continuous pores.

2. A method according to claim 1, wherein said elastomer material is selected from the group consisting polyether-segmented polyurethanes and polyether-segmented polyurethane ureas.

3. A method according to claim 2, wherein said solvent is selected from the group consisting or tetrahydrofuran and dimethylformamide.

4. A method according to claim 1, wherein said inorganic salt is selected from the group of particles of calcium carbonate, magnesium oxide and magnesium hydroxide.

5. A method according to claim 1, wherein more than 500 parts by weight of said inorganic salt is added per 100 parts by weight of said elastomer material.