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Prolonged activity nicotine patch

  • US 4,943,435 A
  • Filed: 10/28/1988
  • Issued: 07/24/1990
  • Est. Priority Date: 10/05/1987
  • Status: Expired due to Term
First Claim
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1. A transdermal patch, comprising:

  • (a) A nicotine depot layer, having a skin-facing side and a skin-distal side, said depot layer containing a sufficient quantity of nicotine to maintain a useful flux of nicotine from said patch for a total time period of 12 hours or more;

    (b) an occlusive backing layer in contact with and covering said depot layer on said skin-distal side; and

    (c) rate-controlling means for controlling diffusion of nicotine from said skin-facing side at a first flux of greater than zero but less than 2 mg/cm2 in any hour for a first time period of greater than zero but less than 5 hours, then at a second flux between 20 and 800 μ

    g/cm2.h for a second time period of 7 hours or more.

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