Solvent system for chronic vascular infusion of hydrophobic drugs

• US 4,943,560 A
• Filed: 04/06/1988
• Issued: 07/24/1990
• Est. Priority Date: 04/06/1988
• Status: Expired due to Term

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Rohde, Thomas D., Wigness, Bruce D.
• Primary Examiner(s): Robinson, Douglas W.
• Assistant Examiner(s): Weddington, Kevin E.
• Application Number:
  US07/178,139
• Time in Patent Office: 839 Days
• Field of Search: 514/11, 514/724
• US Class Current: 514/20.5
• CPC Class Codes: A61K 38/13 Cyclosporins
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00

Abstract

The present invention provides a liquid infusate for the chronic vascular infusion of a hydrophobic biologically-active compound, such as cyclosporin, comprising a solution of a therapeutically-effective amount of the biologically-active compound in a mixture of about 10-80% glycerol and about 90-20% ethanol, by volume.

Claims

1. A liquid infusate for the chronic vascular infusion of a hydrophobic biologically-active compound comprising a solution of therapeutically-effective amount of a cyclosporin in a solvent consisting essentially of about 10-80% glycerol and about 90-20% ethanol, by volume.

2. The infusate of claim 1 which is free of nonionic surfactants.

3. The infusate of claim 1 which contains about 25-500 mg/ml cyclosporin.