Safe oral folic-acid-containing vitamin preparation

• US 4,945,083 A
• Filed: 02/01/1989
• Issued: 07/31/1990
• Est. Priority Date: 06/03/1986
• Status: Expired due to Term

• Current Assignee: Christian J. Jansen Jr
• Original Assignee: Christian J. Jansen Jr
• Inventors: Jansen, Christian J. Jr.
• Primary Examiner(s): Robinson, Douglas W.
• Assistant Examiner(s): Henley, III, Raymond J.
• Application Number:
  US07/305,422
• Time in Patent Office: 545 Days
• Field of Search: 514/814, 514/249, 514/82, 514/80, 514/52
• US Class Current: 514/52
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 31/714 Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12

Abstract

Improved multi-factor hematinic vitamin preparations which provide vitamin B₁₂ and folic acid in a one to one ratio and in safe and fully orally effective daily dosage amounts.

Claims

1. A method of treating or preventing macrocytic-megaloblastic anemia in humans which anemia is caused by either folic acid deficiency or by vitamin B₁₂ deficiency which comprises administering a daily oral dosage of a vitamin preparation to a human in need thereof comprising at least about 0.5 mg. of vitamin B₁₂ and at least about 0.5 mg. of folic acid.

2. The method of claim 1 in which the amount of vitamin B₁₂ and folic acid administered is in an approximate one to one ratio.

3. The method of claim 1 in which the administering includes administering a solid oral dosage form which comprises at least about 0.5 mg. of vitamin B₁₂ and at least about 0.5 mg of folic acid and further comprises a pharmaceutically acceptable iron compound in which the iron component is from 50 to 500 mgs.

4. A method of treating or preventing macrocytic-magaloblastic anemia in humans which anemia is caused by either folic acid deficiency or by vitamin B₁₂ deficiency which comprises orally administering combined vitamin B₁₂ and folic acid to a human in need thereof in sufficient amounts to achieve an oral administration of at least about 0.5 mg. of vitamin B₁₂ and at least about 0.5 mg. of folic acid within one day.

5. The method of claim 4 in which the administering of vitamin B₁₂ and folic acid is in an approximate one to one ratio.

6. The method of claim 4 in which the administering includes administering a solid oral dosage form which comprises at least about 0.5 mg. of vitamin B₁₂, at least about 0.5 mg. of folic acid and a pharmaceutically acceptable iron compound in which the iron component is from 50 to 500 mgs.