Method of treating pre-menstrual syndrome

• US 4,945,103 A
• Filed: 01/17/1989
• Issued: 07/31/1990
• Est. Priority Date: 01/17/1989
• Status: Expired due to Term

• Current Assignee: Applied Medical Research
• Original Assignee: Michael Cohen
• Inventors: Cohen, Michael
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US07/297,328
• Time in Patent Office: 560 Days
• Field of Search: 424/171, 424/415, 424/419
• US Class Current: 514/419
• CPC Class Codes: A61K 31/40 having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• CPC Class Codes: A61P 13/02 of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system

Abstract

A method of treating human females who suffer from pre-menstrual syndrome (PMS) comprises administering melatonin in sufficient doses to relieve the symptoms of PMS.

Claims

1. A method of alleviating premenstrual anxiety, irritability, depression, confusion, fatigue, insomnia, hypersomnia, weight gain, abdominal bloating, pain or tenderness, breast swelling or tenderness, pelvic pain or cramps, increased appetite or weight gain, edema, or a combination thereof which comprises the administration, on a cyclic schedule, of melatonin in a series of daily doses to a human female of child-bearing years who suffers symptoms of PMS, said administration at dosage levels sufficient to alleviate said symptoms.

2. A method in accordance with claim 1 wherein the melatonin is administered in about 3 to about 14 daily doses during the luteal phase of the female'"'"'s menstrual cycle immediately preceding the onset of the female'"'"'s menstrual bleed.

3. A method in accordance with claim 2 wherein the daily dosage level is in the range of about 2 mg. to about 2000 mg per day.

4. A method in accordance with claim 3 wherein the daily dosage level is in the range of about 30 mg. to about 300 mg. per day.

5. A method in accordance with claim 1 wherein the melatonin is administered on each day of the luteal phase and at least some days of the follicular phase of the female'"'"'s menstrual cycle.

6. A method in accordance with claim 5 wherein the daily dosage level is in the range of about 2 mg. to about 300 mg.

7. A method in accordance with claim 6 wherein the daily dosage level is in the range of about 2 mg. to about 100 mg.

8. A method in accordance with claim 1 wherein the melatonin is administered in about 3 to about 14 daily doses immediately preceding the female'"'"'s normal day of ovulation.

9. A method in accordance with claim 8 wherein the daily dosage level is in the range of about 2 mg. to 500 mg.

10. A method in accordance with claim 9 wherein the daily dosage level is in the range of about 30 to about 300 mg.

11. A method in accordance with claim 1 wherein the method of administration is oral.

12. A method in accordance with claim 1 wherein the method of administration is intravenous injection in a physiologically suitable carrier.

13. A method in accordance with claim 1 wherein the method of administration is through an implant.

14. A method in accordance with claim 1 wherein the method of administration is through a suppository.