Membrame-forming veterinary antibacterial teat dip

• US 4,945,110 A
• Filed: 04/14/1989
• Issued: 07/31/1990
• Est. Priority Date: 06/15/1987
• Status: Expired due to Fees

• Current Assignee: US Bank National Association (US Bancorp)
• Original Assignee: Quali-Tech, Inc.
• Inventors: Porubcan, Randolph S., Brokken, Kyle
• Primary Examiner(s): Shah, Mukund J.
• Assistant Examiner(s): WARD, EDWARD C
• Application Number:
  US07/339,197
• Time in Patent Office: 473 Days
• Field of Search: 514/568, 514/578, 514/517, 514/782
• US Class Current: 514/517
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/24 containing ingredients to enhance the sticking of the active ingredients
• CPC Class Codes: A01N 37/02 Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 37/10 Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A61K 9/0041 Mammary glands, e.g. breasts, udder; Intramammary administration

Abstract

A veterinary antibacterial composition is described which is viscosity stabilized, aqueous, topically adherent and forms a relatively tough, self-supporting film that adheres to the animal until removed by water washing. The composition is an aqueous solution of:

an aliphatic sulfate or sulfonate salt detergent;

lactic acid or a food grade salt thereof;

a bactericidal food grade organic acid selected from benzoic acid, sorbic acid, citric acid and lower alkanoic acids, and food grade salts thereof;

a veterinarily acceptable food grade pectin or gum; and

a veterinarily acceptable water soluble emollient selected from short chain aliphatic polyols of up to six carbon atoms;

The composition is suitable, for example, as a teat dip and bacterial control approaching 100% is demonstrated by in vitro and in vivo testing.

Claims

1. A viscosity stabilized, aqueous, topically adherent, self-supporting film-forming veterinary antibacterial composition comprising:

an aliphatic sulfate or sulfonate salt detergent in an amount between about 4 to 8 weight percent of the total composition;

lactic acid, a food grade salt thereof, or admixtures thereof in an amount between 0.01 to 10 weight percent of the total composition;

a bactericidal food grade organic acid selected from benzoic acid, sorbic acid, citric acid, lower alkanoic acids, a food grade salt thereof, or admixtures thereof in an amount between 0.001 to 0.100 weight percent of the total composition;

a film forming food grade pectin or gum in an amount between about 0.02 to 2.5 weight percent of the total composition; and

a veterinarily acceptable water soluble emollient selected from short chain aliphatic polyols of up to six carbon atoms;

having a viscosity stabilized between 80 to 160 cps at 25 degrees C. and forming a topically adherent flexible protective antibacterial barrier film which adheres to the animal until removed by water washing.

2. A composition of claim 1, wherein the aliphatic sulfate or sulfonate salt detergent is selected from sodium, potassium and ammonium aliphatic sulfates and sulfonates and mixtures thereof, containing from 10 to 18 carbons in their aliphatic groups.

3. The composition of claim 2, wherein the aliphatic sulfate salt detergent is dodecyl sulfate salt.

4. The composition of claim 3, wherein the dodecyl sulfate salt detergent is sodium lauryl sulfate.

5. The composition of claim 1, wherein the bactericidal food grade organic acid comprises a mixture of sorbic acid and sodium benzoate.

6. The composition of claim 1, wherein the film forming food grade pectin or gum is selected from citrus pectin, apple pectin, guar gum and carageenan.

7. The composition of claim 6, wherein the citrus pectin is a purified water-soluble natural gum, derived from citrus peel, consisting of partially methoxylated polygalacturonic acid.

8. The composition of claim 7, wherein the citrus pectin additionally contains sodium bicarbonate in minor amount to facilitate the dissolution of the citrus pectin.

9. The composition of claim 1, containing additional veterinarily acceptable ingredients selected from defoamers, dyes, additional antimicrobials, and mixtures thereof.

10. The composition of claim 1, wherein the emollient is selected from glycerin, propylene glycol, sorbitol, ethylene glycol and mixtures thereof.

11. The composition of claim 10, where the emollient is glycerin.

12. The composition of claim 9, wherein the aliphatic sulfate or sulfonate salt detergent is sodium lauryl sulfate, the antibacterially active food grade organic acid is a mixture of sodium benzoate and sorbic acid and the additional veterinarily acceptable ingredients include, a defoamer and a dye.

13. The composition of claim 9, wherein the aliphatic sulfate or sulfonate salt detergent is sodium lauryl sulfate, the antibacterially active food grade organic acid is a mixture of sodium benzoate and sorbic acid, the emollient is glycerin, and the additional veterinarily acceptable ingredients include a defoamer and a dye.

14. A method of preparing a viscosity stabilized, aqueous, topically adherent, film-forming veterinary antibacterial composition according to claim 1, comprising the steps of:

(1) preparing an aqueous solution of the bactericidal food grade organic acid, its food grade salts or mixtures thereof;

(2) preparing an aqueous solution of the film forming food grade pectin or gum, the aliphatic sulfate or sulfonate detergent and lactic acid;

(3) adding the solution of step (1) to the solution of step (2) with thorough mixing; and

(4) adding a veterinarily acceptable water soluble emollient to the solution of step (3) with thorough mixing.

15. The method of claim 14, wherein the bactericidal food grade organic acid comprises a mixture of sorbic acid and sodium benzoate.

16. The method of claim 14, wherein the film forming food grade pectin or gum is citrus pectin or apple pectin.

17. The method of claim 15, wherein the citrus pectin is purified water-soluble natural gum, derived from citrus peel, consisting of partially methoxylated polygalacturonic acid.

18. The method of claim 17, wherein the citrus pectin additionally contains sodium bicarbonate in a minor amount to facilitate the dissolution of the citrus pectin.

19. The method of claim 14, wherein the solution of step (1) additionally comprises veterinarily acceptable ingredients selected from dye and additional antimicrobials.

20. The method of claim 14, wherein the solution of step (2) additionally comprises a veterinarily acceptable defoamer.

21. The method of claim 14, wherein the emollient is selected from glycerin, propylene glycol, sorbitol, ethylene glycol and mixtures thereof.

22. The method of claim 21 wherein the emollient is glycerin.

23. The method of using the composition of claim 1 as a topical veterinary antibacterial composition comprising administering an antibacterially effective amount of the composition topically to animals and allowing the composition to dry to a topically adherent flexible protective film-forming antibacterial barrier.

24. The method of using the composition of claim 1 for control of bovine mastitis comprising applying an antibacterially effective amount of the composition of claim 1 to the teats and udder quarters of bovine animals and allowing the composition to dry to a topically adherent flexible protective film-forming antibacterial barrier.

25. The method of using the composition of claim 13 for the control of bovine mastitis comprising applying an antibacterially effective amount of the composition to the teats and udder quarters of bovine animals and allowing the composition to dry to a topically adherent flexible protective film-forming antibacterial barrier.

26. The method of using the composition of claim 13 as a topical veterinary antibacterial composition comprising administering an antibacterially effective amount of the composition topically to animals and allowing the composition to dry to a topically adherent flexible protective film-forming antibacterial barrier.

27. A viscosity stabilized, aqueous, topically adherent, self-supporting film-forming veterinary antibacterial composition comprising:

sodium lauryl sulfate in amount between about 4 to 8 weight percent of the total composition;

lactic acid, a food grade salt thereof, or admixtures thereof in an amount between 0.01 to 10 weight percent of the total composition;

a bactericidal food grade organic acid selected from benzoic acid, sorbic acid, citric acid, lower alkanoic acids, a food grade salt thereof, or admixtures thereof in an amount between 0.001 to 0.100 weight percent of the total composition;

a film forming food grade pectin or gum in an amount between about 0.02 to 2.5 weight percent of the total composition; and

a veterinarily acceptable water soluble emollient selected from short chain aliphatic polyols of up to six carbon atoms;

having a viscosity stabilized between 80 to 160 cps at 25 degrees C. and forming a topically adherent flexible protective antibacterial barrier film which adheres to the animal until removed by water washing.

28. A viscosity stabilized, aqueous, topically adherent, self-supporting film-forming veterinary antibacterial composition comprising:

an aliphatic sulfate of sulfonate salt detergent in an amount between about 4 to 8 weight percent of the total composition;

lactic acid, a food grate salt thereof, or admixtures thereof in an amount between 0.01 to 10 weight percent of the total composition;

a mixture of sorbic acid and sodium benzoate present in an amount between 0.001 to 0.100 weight percent of the total composition;

a film forming food grade pectin or gum in an amount between about 0.02 to 2.5 weight percent of the total composition; and

a veterinarily acceptable water soluble emollient selected from short chain aliphatic polyols of up to six carbon atoms;

having a viscosity stabilized between 80 to 160 cps at 25 degrees C. and forming a topically adherent flexible protective antibacterial barrier film which adheres to the animal until removed by water washing.

33. A method of preparing a viscosity stabilized, aqueous, topically adherent, film-forming veterinary antibacterial composition according to claim 28, comprising the steps of:

(1) preparing an aqueous solution of the mixture of sorbic acid and sodium benzoate;

(2) preparing an aqueous solution of the bactericidal food grade organic acid, its food grade salts or mixtures thereof;

(3) adding the solution of step (1) to the solution of step (2) with thorough mixing; and

(4) adding a veterinarily acceptable water soluble emollient to the solution of step (3) with thorough mixing.

34. The method of claim 33, wherein the citrus pectin is purified water-soluble natural gum, derived from citrus peel, consisting of partially methoxylated polygalacturonic acid.

35. The method of claim 34, wherein the citrus pectin additionally contains sodium bicarbonate in a minor amount to facilitate the dissolution of the citrus pectin.

29. A viscosity stabilized, aqueous, topically adherent, self-supporting film-forming veterinary antibacterial composition comprising:

sodium lauryl sulfate in an amount between about 4 to 8 weight percent of the total composition;

lactic acid, a food grade salt thereof, or admixtures thereof in an amount between 0.01 to 10 weight percent of the total composition;

a mixture of sorbic acid and sodium benzoate present in an amount between 0.001 to 0.100 weight percent of the total composition;

a film forming food grade pectin or gum in an amount between about 0.02 to 2.5 weight percent of the total composition;

a veterinarily acceptable water soluble emollient selected from short chain aliphatic polyols of up to six carbon atoms;

having a viscosity stabilized between 80 to 160 cps at 25 degrees C. and forming a topically adherent flexible protective antibacterial barrier film which adheres to the animal until removed by water washing.

30. The composition of claim 29, containing additional veterinarily acceptable ingredients selected from defoamers, dyes, additional antimicrobials, and mixtures thereof. m

31. The composition of claim 30, wherein the additional veterinarily acceptable ingredients include, a defoamer and a dye.

32. The composition of claim 31, wherein the emollient is glycerin.