Pacemaker with activity-dependent rate limiting

• US 4,945,909 A
• Filed: 06/06/1989
• Issued: 08/07/1990
• Est. Priority Date: 06/06/1989
• Status: Expired due to Term

• Current Assignee: Cook Pacemaker Corporation (Cook Group Incorporated), Medical Engineering And Development Institute Inc
• Original Assignee: Cook Pacemaker Corporation (Cook Group Incorporated), Medical Engineering And Development Institute Inc
• Inventors: Johnson, William L., Fearnot, Neal E., Stevens, Donald A., Heggs, Kevin S.
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): Manuel, George
• Application Number:
  US07/362,064
• Time in Patent Office: 427 Days
• Field of Search: 128/419 PG, 128/419 P, 128/419 D
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A pacemaker is disclosed with a pacing rate that is restricted within a range defined by variable upper and lower rate limits that change as a function of the patient'"'"'s detected level of activity. An indication such as the nonambient temperature of blood is sensed in the right ventricle of the heart to indicate detected activity level. Other activity indications, such as blood oxygen concentration and body motion, either singly or in combination are also disclosed. A control circuit of the pacemaker varies the upper and lower rate limits according to the patient'"'"'s detected level of activity. The control circuit also varies the atrial and ventricular refractory periods along with the AV delay period in response to detected activity level changes.

Claims

1. A pacemaker with activity-dependent rate limiting, comprising:

electrical sensing circuit means for producing a first control signal indicative of a predetermined electrical activity of a patient'"'"'s heart;

pacing circuit means responsive to an upper rate limit and said first control signal for electrically stimulating said heart at a pacing rate restricted by said upper rate limit; and

control circuit means responsive to an activity signal, from activity sensing circuit means, indicative of a patient'"'"'s level of activity other than said predetermined electrical activity for varying said upper rate limit according to the patient'"'"'s level of activity.

2. The pacemaker of claim 1 wherein said pacing circuit means is further responsive to a lower rate limit for electrically stimulating said heart at said pacing rate restricted by both of said upper and lower rate limits and wherein said control circuit means includes lower rate control means for varying said lower rate limit according to the patient'"'"'s level of activity.

3. The pacemaker of claim 1 wherein said electrical sensing circuit means includes first refractory circuit means for inhibiting said electrical sensing circuit means for a first refractory period after said predetermined electrical activity and wherein said control circuit means includes first refractory control means for varying said first refractory period according to the patient'"'"'s level of activity.

4. The pacemaker of claim 1 further comprising second electrical sensing circuit means for producing a second control signal indicative of a second predetermined electrical activity of said heart and wherein said pacing circuit means is further responsive to a lower rate limit and said second control signal for electrically stimulating said heart at said pacing rate restricted by said lower rate limit and said control circuit means includes lower rate control means for varying said lower rate limit according to the patient'"'"'s level of activity.

5. The pacemaker of claim 4 wherein said second electrical sensing circuit means includes second refractory circuit means for inhibiting said second sensing circuit means for a second refractory period after said second predetermined electrical activity and wherein said control circuit means includes second refractory control means for varying said second refractory period according to the patient'"'"'s level of activity.

6. The pacemaker of claim 5 wherein said pacing circuit means includes delay means for delaying electrically stimulating said heart for a predetermined delay period after said first-recited predetermined electrical activity and wherein said control circuit means includes delay control means for varying said predetermined delay period per a predetermined relationship with said first refractory period according to the patient'"'"'s level of activity.

7. The pacemaker of claim 3 wherein said pacing circuit means includes delay means for delaying electrically stimulating said heart for a predetermined delay period after said predetermined electrical activity and wherein said control circuit means includes delay control means for varying said predetermined delay period per a predetermined relationship with said first refractory period according to the patient'"'"'s level of activity.

8. The pacemaker of claim 1 wherein said electrical sensing circuit means includes first refractory circuit means for inhibiting said electrical sensing circuit means for a first refractory period after said predetermined electrical activity, wherein said upper rate limit is indicative of an upper rate limit period, and wherein said control circuit means includes first refractory control means for varying said first refractory period per a predetermined relationship with said upper rate limit period.

9. The pacemaker of claim 1 wherein said electrical sensing circuit means includes first refractory circuit means for inhibiting said electrical sensing circuit means for a first refractory period after said predetermined electrical activity, wherein said upper rate limit is indicative of an upper rate limit period, and wherein said control circuit means includes first refractory control means for varying said first refractory period with said upper rate limit period, said upper rate limit period and said first refractory period being substantially equal.

10. The pacemaker of claim 1 wherein said pacing circuit means is further responsive to a lower rate limit for electrically stimulating said heart at said pacing rate restricted by both of said upper and lower rate limits and wherein said control circuit means includes lower rate control means for varying said lower rate limit to within a minimum rate difference of said upper rate limit.

11. The pacemaker of claim 1 wherein said pacing circuit means is further responsive to a lower rate limit for electrically stimulating said heart at said pacing rate restricted by both of said upper and lower rate limits and wherein said control circuit means includes lower rate control means for varying said lower rate limit according to the patient'"'"'s level of activity, one of said upper and lower rate limits being varied to within a minimum rate difference of the other.

12. The pacemaker of claim 1 further comprising activity sensing circuit means responsive to the patient'"'"'s level of activity for producing said activity signal indicative of the patient'"'"'s level of activity and wherein said control circuit means is responsive to said activity signal for varying said upper rate limit according to the patient'"'"'s level of activity.

13. The pacemaker of claim 12 wherein said activity sensing circuit means includes temperatures sensing circuit means responsive to a blood temperature in said heart indicative of the patient'"'"'s level of activity for producing said activity signal.

14. The pacemaker of claim 12 wherein said activity sensing circuit means includes motion sensing circuit means responsive to a motion of a patient'"'"'s body indicative of the patient'"'"'s level of activity for producing said activity signal.

15. The pacemaker of claim 12 wherein said activity sensing circuit means includes a first indication sensing circuit means responsive to a first indication indicative of the patient'"'"'s level of activity for producing a first indication signal indicative of said first indication.

16. The pacemaker of claim 15 wherein said activity sensing circuit means includes a second indication sensing circuit means responsive to a second indication indicative of the patient'"'"'s level of activity for producing a second indication signal indicative of said second indication.

17. The pacemaker of claim 16 wherein said activity sensing circuit means further includes combiner circuit means responsive to said first and second indication signals and a predetermined combinational algorithm for producing said activity signal.

32. The pacemaker of claim 1 wherein said first sensing means includes means for sensing ventricular electrical activity.

33. The pacemaker of claim 32 further comprising atrial refractory circuit means for inhibiting said first sensing means for an atrial refractory period after detection of said predetermined electrical activity by said first sensing means, and wherein said control circuit means increases said upper rate limit and decreases the atrial refractory period when the patient'"'"'s level of activity increases.

34. The pacemaker of claim 33 wherein said pacing circuit means further includes means for generating atrial pulses in the absence of said predetermined, electrical activity.

18. A pacemaker with activity-dependent rate limiting, comprising:

an atrial sensing circuit responsive to electrical activity in an atrium of a patient'"'"'s heart for producing a first control signal indicative of a predetermined atrial electrical activity;

a pacing circuit responsive to said first control signal and an upper rate limit for electrically stimulating a ventricle of said heart subsequent to said predetermined atrial electrical activity and at a ventricular pacing rate limited by said upper rate limit; and

a control circuit responsive to an activity signal, from activity sensing circuit means, indicative of the patient'"'"'s level of activity and including an upper rate limit control unit for varying said upper rate limit according to the patient'"'"'s level of activity.

19. The pacemaker of claim 18 wherein said pacing circuit is further responsive to a lower rate limit for electrically stimulating said ventricle at said ventricular pacing rate limited by both of said upper and lower rate limits and wherein said control circuit further includes a lower rate limit control unit for varying said lower rate limit according to the patient'"'"'s level of activity.

20. The pacemaker of claim 19 wherein said pacing circuit includes a delay circuit for delaying electrically stimulating said ventricle for a predetermined delay period after said predetermined atrial electrical activity and wherein said control circuit further includes a delay control unit for varying said predetermined delay period according to the patient'"'"'s level of activity.

21. The pacemaker of claim 20 further comprising an atrial refractory circuit for inhibiting said atrial sensing circuit for an atrial refractory period after said redetermined atrial electrical activity.

22. The pacemaker of claim 21 wherein said control circuit further includes an atrial refractory control unit for varying said atrial refractory period according to the patient'"'"'s level of activity.

23. The pacemaker of claim 22 further comprising a ventricular sensing circuit responsive to electrical activity in said ventricle for producing a second control signal indicative of a predetermined ventricular electrical activity and wherein said pacing circuit is further responsive to said second control signal for electrically stimulating said ventricle on demand after said predetermined delay period.

24. The pacemaker of claim 22 further comprising a ventricular refractory circuit for inhibiting said ventricular sensing circuit for a ventricular refractory period after said predetermined ventricular electrical activity.

25. The pacemaker of claim 24 wherein said control circuit further includes a ventricular refractory control unit for varying said ventricular refractory period according to the patient'"'"'s level of activity.

26. The pacemaker of claim 25 further comprising a temperature sensing circuit responsive to a blood temperature in said ventricle for producing said activity signal indicative of the patient'"'"'s level of activity and wherein said control circuit is responsive to said activity signal for varying said upper rate limit.

27. The pacemaker of claim 25 further comprising a motion sensing circuit responsive to a motion of the patient'"'"'s body indicative of the patient'"'"'s level of activity for producing said activity signal indicative of the patient'"'"'s level of activity and wherein said control circuit is responsive to said activity signal for varying said upper rate limit.

28. The pacemaker of claim 25 further comprising:

a temperature sensing circuit responsive to a blood temperature in said ventricle for producing a first indication signal indicative of the patient'"'"'t level of activity;

a motion sensing circuit responsive to a motion of patient'"'"'s body for producing a second indication signal indicative of the patient'"'"'s level of activity;

a combiner circuit responsive to said first and second indication signals and a predetermined combinational algorithm for producing said activity signal; and

wherein said control circuit is responsive to said activity signal for varying said upper rate limit.

29. An atrioventricular pacemaker with activity-dependent rate limiting, comprising:

an atrial sensing circuit response to electrical activity in a patient'"'"'s heart for producing a first control signal indicative of an atrial depolarization;

an atrial refractory circuit for inhibiting said atrial sensing circuit for an atrial refractory period after said atrial depolarization;

an atrial refractory control unit responsive to a blood temperature in said heart indicative of the patient'"'"'s level of activity for varying said atrial refractory period according to the patient'"'"'s level of activity;

an upper rate limit control unit responsive to said blood temperature for varying an upper rate limit according to the patient'"'"'s level of activity;

a lower rate limit control unit responsive to said blood temperature for varying a lower rate limit according to the patient'"'"'s level of activity;

a ventricular sensing circuit responsive to said electrical activity for producing a second control signal indicative of a ventricular depolarization;

a ventricular refractory circuit for inhibiting said second sensing circuit for a ventricular refractory period;

a ventricular refractory control unit responsive to said blood temperature for varying said ventricular refractory period according to the patient'"'"'s level of activity;

a pacing circuit responsive to said first and second control signals for electrically stimulating an atrium and a ventricle of said heart on demand at a pacing rate limited by said upper and lower rate limits;

a delay circuit responsive to said first control signal for delaying electrically stimulating said ventricle for a predetermined delay period after said atrial depolarization; and

a delay control unit responsive to said blood temperature for varying said delay period according to the patient'"'"'s level of activity.

30. An atrioventricular pacemaker with activity-dependent rate limiting, comprising:

first sensing means for sensing electrical activity in a patient'"'"'s heart, said sensing means including means for detecting predetermined electrical activity indicative of a P-wave;

second sensing means for sensing a patient'"'"'s level of activity other than said predetermined electrical activity;

control circuit means coupled to said second sensing means for generating an upper and a lower rate limit for the patient'"'"'s level of activity; and

pacing circuit means for generating a ventricular pulse after a predetermined AV delay period in response to detection of said predetermined electrical activity by said first sensing means, whereby the ventricular pulse rate normally equals the sensed atrial rate, said pacing circuit means including means for limiting the ventricular pulse rate to within a range restricted by said upper and lower rate limits, said control circuit means including means for varying said upper rate limit according to the patient'"'"'s level of activity, whereby the ventricular pulse rate follows the sensed atrial rate up to said upper rate limit determined by the patient'"'"'s cardiac output requirement.

31. The pacemaker of claim 30 wherein said control circuit means varies both of said upper and lower rate limits in response to the patient'"'"'s level of activity, whereby the patient'"'"'s level of activity determines both of said rate limits.

35. The pacemaker of claim 30 further comprising atrial refractory circuit means for inhibiting said first sensing means for an atrial refractory period after detection of said predetermined electrical activity by said first sensing means, and wherein said control circuit means increases said upper rate limit and decreases the atrial refractory period when the patient'"'"'s level of activity increases.

36. The pacemaker of claim 35 wherein said control circuit includes means for varying both of said upper and lower rate limits in response to changes in the patient'"'"'s level of activity.

37. The pacemaker of claim 36 further comprising third sensing means for sensing ventricular electrical activity.

38. The pacemaker of claim 37 wherein said pacing circuit means further includes means for generating atrial pulses in the absence of said predetermined electrical activity.