Multi-well filter strip and composite assemblies
First Claim
1. A filter assembly comprisinga multi-well filter strip having a plurality of wells, each of the wells having side walls and open top and bottom ends,each of the wells further having a separate filter membrane attached to a bottom surface of the side walls and closing the open bottom end of each well of the strip,an array of wells having open top and closed bottom ends and being spaced so that the array of closed bottom wells will align with the wells of the filter strip, anda transfer plate having means for supporting each membrane adjacent the bottom ends of the respective wells in the filter strip and for engaging each of the wells in the array adjacent the open top end thereof for causing filtrate passing through the membranes on the wells in the filter strip to enter the corresponding separate wells in the array of wells aligned therewith.
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Accused Products
Abstract
A filter strip and composite assemblies for filtering microliter quantities of fluids. A linear array of wells having open top and bottom ends are connected by frangible webs in spaced-apart relation with discrete filter membranes closing the bottom ends of each well. Tabs are provided on the ends of the filter strip for holding the same and supporting the strip in a rectangular holder having alpha-numeric designations for identifying each well in a plurality of such filter strips contained within the holder. The filter strip may be used in a vacuum manifold for applying a pressure differential across the filter membrane and directing the filtrate into an aligned aperture of a closed bottom well of an array of wells held within the manifold. Alternatively, the filter strip may be used with a transfer plate for directing the filtrate from each well of the filter strip to an aligned well of a closed bottom array of wells. Another composite assembly includes a pressure manifold for applying an increased pressure above the membranes.
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Citations
9 Claims
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1. A filter assembly comprising
a multi-well filter strip having a plurality of wells, each of the wells having side walls and open top and bottom ends, each of the wells further having a separate filter membrane attached to a bottom surface of the side walls and closing the open bottom end of each well of the strip, an array of wells having open top and closed bottom ends and being spaced so that the array of closed bottom wells will align with the wells of the filter strip, and a transfer plate having means for supporting each membrane adjacent the bottom ends of the respective wells in the filter strip and for engaging each of the wells in the array adjacent the open top end thereof for causing filtrate passing through the membranes on the wells in the filter strip to enter the corresponding separate wells in the array of wells aligned therewith.
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5. A filter assembly comprising:
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a multi-well filter strip having a plurality of wells, each of the wells having side walls and open top and bottom ends, each of the wells further having a separate filter membrane attached to a bottom surface of the side walls and closing the open bottom end of each well of the strip, a transfer plate having means for supporting each membrane adjacent the bottom ends of the respective wells; and means defining openings in the transfer plate adjacent each membrane, wherein by applying a reduced pressure beneath the membrane to draw liquid in the wells through the membranes the supporting means maintains the membrane attachment to the well. - View Dependent Claims (6, 7, 8, 9)
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Specification