Non-thrombogenic intravascular time release catheter

• US 4,950,256 A
• Filed: 01/11/1990
• Issued: 08/21/1990
• Est. Priority Date: 04/07/1988
• Status: Expired due to Fees

• Current Assignee: Luther Medical Products, Inc. (Becton, Dickinson & Co)
• Original Assignee: Luther Medical Products, Inc. (Becton, Dickinson & Co)
• Inventors: Shanbrom, Edward, Luther, Ronald B.
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Rose, Sharon
• Application Number:
  US07/462,911
• Time in Patent Office: 222 Days
• Field of Search: 604/265, 604/266
• US Class Current: 604/265
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 33/0041 characterised by the choice of an antithrombatic agent other than heparin heparinoïd A61L33/08; polypeptides A61L33/12

Abstract

An intravascular catheter comprising a cannula for insertion into a vascular system of a patient coated with hydrophilic polymer containing, in the polymer, an effective amount of polymyxin to prevent the growth of microorganisms is disclosed.

Claims

1. An invasive device comprising a structure constructed and dimensioned for insertion into a patient for residing in contact with a fluid in the patient which contains fibrinogen-fibrin capable of forming clots, and a coating on the structure, said coating consisting essentially of three-dimensional polymer formed of polyurethane polyene compositions obtained by reacting from about 10 to about 50 parts by weight of a polyene in the presence of about 100 parts by weight of a hydrophilic polyurethane resin, said coating having absorbed therein an amount of antimicrobial anticoagulant consisting essentially of polymyxin in amount effective to inhibit growth of bacteria and the formation of blood clots on said coating.