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Collagen wound healing matrices and process for their production

  • US 4,950,483 A
  • Filed: 12/16/1988
  • Issued: 08/21/1990
  • Est. Priority Date: 06/30/1988
  • Status: Expired due to Term
First Claim
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1. A collagen sponge composition, comprising:

  • a matrix having a density of about 0.01 to about 0.3 g/cm3, a thickness of about 1-20 mm, and having pores at least 80% of which are at least 35 um in diameter, wherein said matrix comprisesfibrillar atelopeptide collagen, wherein said fibrils are about 50-200 nm in diameter, and are not chemically cross-linked; and

    a synergistic wound-healing effective amount of TGF-B and FGF.

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