Process for synthesis of oligonucleotides and compound for forming polymeric protecting group
First Claim
1. A compound for forming a polysaccharide derivative protecting group, which is represented by the following general formula (I):
- ##STR17## wherein C6 H7 O2 stands for an anhydrous glucose residue, R stands for ##STR18## n is a number of 10 to 2,000, x is a number of 0.4 to 0.8, and y is a number of 1.0 to 2.0.
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Accused Products
Abstract
A chain-extended oligonucleotide is synthesized by condensing a mononucleotide, oligonucleotide, mononucleoside succinate or oligonucleotide succinate in which only the terminal 5'"'"'-hydroxyl group is not blocked and the other functional groups are blocked by a plurality of low-molecular-weight protecting groups and one polysaccharide derivative protecting group, with a mononucleotide or oligonucleotide in which the functional groups other than the terminal phosphoric acid group ar blocked by low-molecular-weight protecting groups in the homogeneous system in a common solvent.
A compound represented by the following formula is preferred as the compound forming the polysaccharide derivative protecting group: ##STR1## wherein C6 H7 O2 stands for an anhydrous glucose residue, R stands for ##STR2## n is a number of 10 to 2,000, x is a number of 0.4 to 0.8, and y is a number of 1.0 to 2.0.
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2 Claims
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1. A compound for forming a polysaccharide derivative protecting group, which is represented by the following general formula (I):
- ##STR17## wherein C6 H7 O2 stands for an anhydrous glucose residue, R stands for ##STR18## n is a number of 10 to 2,000, x is a number of 0.4 to 0.8, and y is a number of 1.0 to 2.0.
- View Dependent Claims (2)
Specification