Heat sealable membrane for transdermal drug release
First Claim
1. In a transdermal drug delivery system, comprising in combination:
- (a) an impermeable backing member;
(b) a release rate controlling membrane heat and pressure sealed to said backing member without the use of a separate adhesive;
(c) a reservoir positioned between said backing member and said membrane containing a medicinally active ingredient;
(d) means to attach said system to the skin of a patient;
said member comprising a substantially linear block copolymer which is a reaction product of a polydiorganosiloxane oligomer which forms soft segments in a said reaction product and a diisocyanate which forms hard segments, said copolymer having a glass transition temperature between 75°
C. and 200°
C. said soft segments comprising from 60 to 90 percent by weight , based on the weight of said copolymer and said hard segments comprising from about 10 to 40 percent by weight thereof.
1 Assignment
0 Petitions
Accused Products
Abstract
A transdermal drug delivery system, is provided which includes, in combination, an impermeable backing member, a release rate controlling membrane, and, a reservoir containing a medicinally active ingredient; the improvement in such system is based on the fact that said membrane is heat and pressure sealed to said backing without the use of a separate adhesive and is formed of a substantially linear block copolymer which is a reaction product of an amino functional polydiorganosiloxane which forms soft segments in said reaction product and a diisocyanate which forms "hard" segments, said copolymer having a glass transition temperature between 50° C. and 200° C. said soft segments comprising from 60 to 90 percent by weight, based on the weight of said copolymer.
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Citations
10 Claims
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1. In a transdermal drug delivery system, comprising in combination:
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(a) an impermeable backing member; (b) a release rate controlling membrane heat and pressure sealed to said backing member without the use of a separate adhesive; (c) a reservoir positioned between said backing member and said membrane containing a medicinally active ingredient; (d) means to attach said system to the skin of a patient; said member comprising a substantially linear block copolymer which is a reaction product of a polydiorganosiloxane oligomer which forms soft segments in a said reaction product and a diisocyanate which forms hard segments, said copolymer having a glass transition temperature between 75°
C. and 200°
C. said soft segments comprising from 60 to 90 percent by weight , based on the weight of said copolymer and said hard segments comprising from about 10 to 40 percent by weight thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for forming a transdermal drug delivery device comprising (A) providing an impermeable backing member, (B) positioning a drug containing reservoir over a central portion of said backing member (C) positioning a rate controlling membrane over said reservoir with the periphery thereof extending beyond the perimeter of said reservoir, said periphery overlying said backing without any separate adhesive therebetween, said rate controlling polymeric material being from 0.01 to 1 mm. thick and permeable to said drug, said polymeric material comprising substantially linear block copolymers comprising from 3 to 40 weight percent of hard segments consisting essentially of polyurethane units derived from an organic diisocyanate and an alkylene diol, and from 60 to 97 weight percent of soft segments comprising at least one polydiorganosiloxane unit, said copolymer having a glass transition temperature between 50°
- and 200°
C., and (D) sealing the periphery of said membrane to said backing by applying heat and pressure thereto. - View Dependent Claims (9, 10)
- and 200°
Specification