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Ocular treatment

  • US 4,952,212 A
  • Filed: 01/23/1989
  • Issued: 08/28/1990
  • Est. Priority Date: 11/13/1985
  • Status: Expired due to Term
First Claim
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1. An improved method of administering an ophthalmically active formulation to the corneal surface of an eye, said improvement essentially comprising the steps of:

  • providing a nozzle having an outlet adjacent an electrode, which electrode is spaced from said outlet and electrically insulated from said nozzle;

    providing as said formulation a liquid mixture comprised of an ophthalmically active substance and an ophthalmically acceptable diluent;

    placing said nozzle outlet and adjacent electrode in proximity to, but spaced from, said corneal surface;

    causing a measured unit dose of up to 20 μ

    l of said formulation to flow from said nozzle outlet simultaneously with applying to said formulation an electrical potential by means of a high voltage generator while maintaining said electrode at relative ground potential, said electrical potential being sufficiently large to atomize said formulation leaving said nozzle outlet into a spray of electrically charged droplets;

    whereupon said electrically charged droplets of said formulation are drawn to said corneal surface and uniformly deposited thereover.

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